United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics Market Report with Executive Summary, Size, Analysis and Forecast to 2023-2028

Report Overview

The UK Paroxysmal Nocturnal Haemoglobinuria Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Paroxysmal Nocturnal Haemoglobinuria (PNH) is a very rare and debilitating disease of the bone marrow that affects the blood and major organs. It is a chronic, life-threatening illness and can have devastating effects upon a patient physically, mentally, and emotionally.

PNH is an acquired illness caused by an injury to a bone marrow stem cell and is not hereditary. The bone marrow produces all blood cells for the body, being white cells, red cells, and platelets. PNH occurs when a gene required for producing normal blood cells becomes mutated resulting in a PNH clone of bone marrow cells that produce defective blood cells. The white blood cells and platelets do not function as effectively as normal cells, leaving patients prone to infections and blood clots. While all three types of blood cells are affected by PNH, most of the symptoms experienced by patients are due to the destruction of red blood cells.

The overall incidence rate was estimated at 0.35 cases per 100,000 people per year. This equates to 220 cases newly diagnosed in the UK each year. The overall prevalence rate was 3.81 per 100,000, this equates to an estimated 2,400 prevalent cases in the UK. PNH is believed to affect males and females in equal numbers. The disorder has been described in many racial groups.

Market Growth Drivers

Factors driving the PNH treatment market include a rise in the number of blood & bone marrow related disorders, increase in incidence and prevalence of patients suffering from PNH disease, rise in aging population, growing disposable income coupled with the unmet need of treatment of PNH, and technological advancements in stem cells transplantation.

In addition to this, the emergence of biologics and adoption of novel therapeutics are further pushing the market growth and anticipated to account for the higher market share over the forecast period.

Market Restraints

However, an increase in the cost of medical equipment, specifically surgical equipment required for stem cell transformation, lack of reimbursement policies, and occurrence of side effects in related currently available treatments may hamper the PNH treatment market over the forecast period.

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Top Major Players

The PNH treatment market is highly competitive, and the prominent players in the market have adopted various strategies to garner maximum market share. These include collaboration, product launch, partnership, and acquisition. The major player operating in the market include Alexion Pharmaceuticals Ltd, RA Pharmaceuticals Ltd, Volution Immuno Pharmaceuticals Ltd, Akari Therapeutics Plc, BioCryst Pharmaceuticals Inc, and Alnylam Pharmaceuticals Inc. among others.

The report delivers the challenges in front of the United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics Market 2023 that allows a better understanding of the market providing a helpful comprehensive evaluation and clear-cut dynamics associated with this market. The analyst has studied the current market scenario while concentrating on the new business objectives with the lucrative opportunities that are available. This report includes changes in customer requirements, customer preferences, and the vendor landscape in the industry with key factors that are expected to influence the overall dynamics of the United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeuticss Market including the current trends, growth opportunities, restraints, and market drivers.

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Market Segmentation

By Diagnosis:

On the basis of diagnosis, the PNH treatment market can be classified into

Complete Blood Count Test
Lactate Dehydrogenase Test (LDH)
Bilirubin Test
Bone Marrow Examination
Flow Cytometry
Others

By Treatment:

Based on the treatment, the PNH treatment market can be bifurcated into

Soliris (eculizumab)
Transfusions of red blood cells
Folic acid therapy
Steroids (e.g., androgens, glucocorticoids)
Anticoagulants
Potential adjunctive therapies
Others

The treatment of PNH is directed at the specific symptoms that are present in each individual and includes a variety of different therapeutic options. The regulatory authority approved the orphan drug Soliris (eculizumab) as a treatment for PNH disorder.

Pre-complement inhibitor treatment includes transfusions of red blood cells, iron and/or folic acid therapy, steroids (e.g., androgens, glucocorticoids), and anticoagulants.

Treatment of PNH by complement inhibitor represents a major advance in treatment. The currently available complement inhibitor (eculizumab) is a monoclonal antibody that is administered through intravenous infusion.

Potential adjunctive therapies can be continued during eculizumab therapy if the treating hematologist considers it appropriate. For a hemolytic crisis, narcotic pain relief and fluids may be appropriate. Blood transfusions may be required to support hemoglobin levels.

By Distribution Channels:

In terms of distribution channel, the primary hyperoxaluria treatment market can be classified into

Hospital pharmacies
Retail pharmacies
Online pharmacies

In terms of value (around more than 70%), the hospital pharmacies accounted for the leading market share in 2020. Moreover, it is anticipated to witness growth during the forecast period as most of the products are prescription products, which are available in hospital pharmacies.

Top Major Players

The PNH treatment market is highly competitive, and the prominent players in the market have adopted various strategies to garner maximum market share. These include collaboration, product launch, partnership, and acquisition. The major player operating in the market include Alexion Pharmaceuticals Ltd, RA Pharmaceuticals Ltd, Volution Immuno Pharmaceuticals Ltd, Akari Therapeutics Plc, BioCryst Pharmaceuticals Inc, and Alnylam Pharmaceuticals Inc. among others.

The United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics Market report is an easy-to-understand document giving section-wise details about the global market. Starting with the brief outline of the overall market, it will put forth the all-inclusive evaluated market statistics and different parameters for the forecast period. The report covers numerous aspects of the United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics market divided into product kind, application, and end-use, offering the report to assist the customers in improving their ability to make precise decisions related to the business under the United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics Market.

International Market Players will use the correct market facts and figures and applied math studies provided within the report back to perceive this and future growth of the worldwide Electrophoretic United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics market. Each section of the research study is specially prepared to explore key aspects of the global United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics Market. Buyers of the report will have access to accurate PESTLE, SWOT, and other types of analysis on the global United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics market. Moreover, it offers highly accurate estimations on the CAGR, market share, and market size of key regions and countries.

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Strategic Points Covered in Table of Content of Global United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics Market:

Chapter 1: Introduction, market driving force product Objective of Study and Research Scope the United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics market
Chapter 2: Exclusive Summary - the basic information of the United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics Market.
Chapter 3: Displaying the Market Dynamics- Drivers, Trends and Challenges & Opportunities of the United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics
Chapter 4: Presenting the United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics Market Factor Analysis, Porters Five Forces, Supply/Value Chain, PESTEL analysis, Market Entropy, Patent/Trademark Analysis.
Chapter 5: Displaying the by Type, End User and Region/Country
Chapter 6: Evaluating the leading manufacturers of the United Kingdom Paroxysmal Nocturnal Haemoglobinuria Therapeutics market which consists of its Competitive Landscape, Peer Group Analysis, BCG Matrix & Company Profile
Chapter 7: To evaluate the market by segments, by countries and by Manufacturers/Company with revenue share and sales by key countries in these various regions
Chapter 8 & 9: Displaying the Appendix, Methodology and Data Source

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