Press release
AL Amyloidosis Pipeline Appears Robust With 10+ Key Pharma Companies Actively Working in the Therapeutics Segment
In the AL Amyloidosis Pipeline Report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, A L Amyloidosis collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Key takeaways from the AL Amyloidosis Pipeline Report
• DelveInsight's AL Amyloidosis Pipeline analysis depicts the space with 10+ active players working to develop 10+ pipeline therapies.
• The leading AL Amyloidosis Companies includes Merck & Co, Janssen Pharmaceutical, Caelum Biosciences, Oncopeptides AB, Bristol-Myers Squibb, Acrotech biopharma, Sanofi, Astellas Pharma GmbH, and others.
• Promising AL Amyloidosis Pipeline Therapies includes CAEL-101, Daratumumab, Ixazomib, Cyclophosphamide, Dexamethasone, Bendamustine, Pomalidomide, NEOD001, Siltuximab and others.
• The AL Amyloidosis companies and academics are working to assess challenges and seek opportunities that could influence AL Amyloidosis R&D. The AL Amyloidosis pipeline therapies under development are focused on novel approaches to treat/improve AL Amyloidosis.
Explore more information on the latest breakthroughs in the AL Amyloidosis Treatment Landscape of the report and AL Amyloidosis Pipeline Outlook @ https://www.delveinsight.com/sample-request/al-amyloidosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
AL Amyloidosis Overview
Amyloid light-chain amyloidosis, (AL) is the most common form of systemic amyloidosis and is associated with an underlying plasma cell dyscrasia. AL amyloidosis is caused by a bone marrow disorder. The bone marrow in the center of bones produces cells in the blood system, including "plasma cells." These plasma cells are the part of the immune system that makes antibodies for fighting infections. The term "immunoglobulin" refers to the class of proteins that function as antibodies.
AL Amyloidosis Emerging Drugs Profile
• CAEL-101: Caelum Biosciences
CAEL-101 is a first-in-class anti-amyloid antibody designed to improve organ function by reducing or eliminating amyloid deposits in patients with amyloid light chain (AL) amyloidosis. Alexion is collaborating with Caelum Biosciences to develop CAEL-101 for light chain (AL) amyloidosis, a rare systemic disorder that causes misfolded immunoglobulin light chain protein to build up in and around tissues, resulting in progressive and widespread organ damage. Alexion and Caelum Biosciences are conducting the Cardiac Amyloid Reaching for Extended Survival (CARES) Phase 3 clinical program to evaluate CAEL-101, a first-in-class amyloid fibril targeted therapy, in combination with standard-of-care therapy in AL amyloidosis. CAEL-101 has received Orphan Drug Designation from both the U.S. Food and Drug Administration and European Medicine Agency as a therapy for patients with AL amyloidosis.
• Ixazomib: Takeda
Ninlaro (ixazomib) is a proteasome inhibitor. Ixazomib preferentially binds and inhibits the chymotrypsin-like activity of the beta 5 subunit of the 20S proteasome. Ixazomib induced apoptosis of multiple myeloma cell lines in vitro. The drug is being evaluated in Phase III stage of development for the treatment of patients with AL Amyloidosis.
• Belantamab mafodotin: GlaxoSmithKline
Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen (BCMA) conjugated to the microtubule distrupter monomethyl auristatin-F (MMAF).1 Afucosylation of the Fc region of monoclonal antibodies enhances binding to the Fc region, which enhances antibody dependant cell mediated cytoxicity. Phase II clinical Study of Belantamab Mafodotin has been initiated to treat Patients with Relapsed or Refractory AL Amyloidosis.
• STI 6129 : Sorrento Therapeutics
STI-6129 is an ADC with covalently bound duostatin tubulin inhibitors (Duostatin 5) using a proprietary site-specific C-LOCK™ chemical linker designed to reduce the premature systemic release of duostatin and avoid the potential for toxicity, particular ocular toxicity, seen with other ADCs, especially first-generation products. STI-6129 has demonstrated an improved therapeutic index in animal models, as compared to traditional non-selective conjugates. STI-6129 has the potential for being a first-line treatment for amyloidosis as well as second line in those patients who have developed daratumumab resistance, an anti-CD38 mAb alone. STI-6129 binds to different epitopes than daratumumab and the addition of the targeted delivery of the duostatin can potentially manage those patients who have become refractory to such treatments.
Request a sample and discover the recent advances in AL Amyloidosis Pipeline Therapies, visit AL Amyloidosis Treatment Landscape @ https://www.delveinsight.com/sample-request/al-amyloidosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
AL Amyloidosis Pipeline Therapeutics Assessment
There are approx. 10+ key companies which are developing the therapies for AL Amyloidosis. The companies which have their A L Amyloidosis drug candidates in the most advanced stage, i.e. phase III include, Caelum Biosciences.
AL Amyloidosis Pipeline: Phases
• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
Get to know more information about the AL Amyloidosis Emerging Drugs and AL Amyloidosis Companies of the report @ https://www.delveinsight.com/sample-request/al-amyloidosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Scope of the AL Amyloidosis Pipeline Report
• Coverage- Global
• AL Amyloidosis Companies- Merck & Co, Janssen Pharmaceutical, Caelum Biosciences, Oncopeptides AB, Bristol-Myers Squibb, Acrotech biopharma, Sanofi, Astellas Pharma GmbH, and others.
• AL Amyloidosis Pipeline Therapies- CAEL-101, Daratumumab, Ixazomib, Cyclophosphamide, Dexamethasone, Bendamustine, Pomalidomide, NEOD001, Siltuximab and others.
• AL Amyloidosis Pipeline Segmentation: Product Type, Molecule Type, Mechanism of Action, Route of Administration
Dive deep into rich insights for drugs for AL Amyloidosis Market Drivers and AL Amyloidosis Market Barriers, click here AL Amyloidosis Unmet Needs and Analyst Views @ https://www.delveinsight.com/sample-request/al-amyloidosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
Table of Content
1. Introduction
2. Executive Summary
3. AL Amyloidosis: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. AL Amyloidosis- DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. CAEL-101: Caelum Biosciences
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. Belantamab mafodotin : GlaxoSmithKline
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. STI-6129: Sorrento Therapeutics
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. Drug name: Company Name
18. Drug profiles in the detailed report…..
19. Inactive Products
20. AL Amyloidosis Key Companies
21. AL Amyloidosis Key Products
22. AL Amyloidosis- Unmet Needs
23. AL Amyloidosis- Market Drivers and Barriers
24. AL Amyloidosis- Future Perspectives and Conclusion
25. AL Amyloidosis Analyst Views
26. AL Amyloidosis Key Companies
27. Appendix
Got Queries? Find out the related information on AL Amyloidosis Mergers and acquisitions, AL Amyloidosis Licensing Activities, and Click here for AL Amyloidosis Emerging Drugs, and Recent Trends @ https://www.delveinsight.com/sample-request/al-amyloidosis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr
About Us
DelveInsight is a Business Consulting and Market research company, providing expert business solutions for the healthcare domain and offering quintessential advisory services in the areas of R&D, Strategy Formulation, Operations, Competitive Intelligence, Competitive Landscaping, and Mergers & Acquisitions.
Company Name: DelveInsight
Contact Person: Yash Bhardwaj
Email: info@delveinsight.com
Phone: 9193216187
Address: 304 S. Jones Blvd #2432
City: Las Vegas
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Country: United States
Website: https://www.delveinsight.com/
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