Oligonucleotide Synthesis Goes Mainstream: Growing Adoption and Technological Advancements Drive Market Growth

Oligonucleotide Synthesis

Oligonucleotide synthesis is the process of building short sequences of nucleotides, the building blocks of DNA and RNA, using chemical techniques. Oligonucleotides are typically short, single-stranded pieces of nucleic acid that can be used for a variety of purposes, including as probes for detecting specific nucleic acid sequences, primers for PCR amplification, and as therapeutic agents in gene therapy.

There are a number of methods for synthesizing oligonucleotides, but the most commonly used method is solid-phase synthesis. In this technique, a solid support, typically a small bead, is used to anchor the first nucleotide in the sequence. The nucleotide is then modified with a chemical group that can be selectively removed to allow the addition of the next nucleotide in the sequence. This cycle is repeated until the desired sequence has been built up on the solid support. Finally, the oligonucleotide is cleaved from the solid support and purified.

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Other methods of oligonucleotide synthesis include solution-phase synthesis, in which the nucleotides are synthesized in solution rather than on a solid support, and enzymatic synthesis, in which enzymes are used to build up the sequence.

Oligonucleotide synthesis is a critical tool in molecular biology and biotechnology, enabling the study and manipulation of genetic information.

•CAGR: 17.1%
• Current Market Size: USD 197.5 Million
• Forecast Growing Region: APAC
• Largest Market: North America
• Projection Time: 2021- 2031
• Base Year: 2021

Oligonucleotide Synthesis Market

The oligonucleotide synthesis market refers to the industry that produces and sells synthetic oligonucleotides, which are short strands of nucleic acid that are used in various applications, such as research, diagnostics, and therapeutics. The market has seen steady growth in recent years due to the increasing demand for oligonucleotides in molecular biology and biotechnology.

One major driver of the oligonucleotide synthesis market is the growing demand for oligonucleotides in research and diagnostic applications. Oligonucleotides are used as probes for detecting specific nucleic acid sequences, as primers for PCR amplification, and as tools for studying gene expression and regulation.

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Another major driver of the market is the increasing use of oligonucleotides as therapeutic agents in gene therapy. Oligonucleotides can be designed to target specific genes or proteins, and they have shown promise in treating a variety of diseases, such as cancer and genetic disorders.
The market for oligonucleotide synthesis is highly competitive, with a number of major players, including Thermo Fisher Scientific, Merck KGaA, Integrated DNA Technologies, and Eurofins Scientific. These companies offer a range of products and services, including custom oligonucleotide synthesis, oligonucleotide libraries, and oligonucleotide-based therapeutics.

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