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Lassa Fever - Pipeline Assessment, 2023 Updates | In-depth Insights into the Clinical Trials, Emerging Drugs, Latest FDA, EMA, and PMDA Approvals, and Treatment Outlook | Inovio Pharmaceuticals, Emergent BioSolutions Inc, GeoVax Labs Inc, Globavir Bioscie
Lassa Fever Pipeline Insight
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Lassa fever is an acute viral hemorrhagic illness caused by Lassa virus, a member of the arenavirus family of viruses. It is a hemorrhagic virus that can cause bleeding without any symptoms.
Lassa fever virus is a disease that is animal-borne or spread to humans from animals. It is spread to people through contact with household items, food, water, or air contaminated with the droppings or urine of infected multimammate rats (Mastomyces natalensis). The most common method of transmission is by consuming or inhaling rat urine or feces. It can also be spread through cuts and open sores. Person-to-person contact is possible via blood, tissue, secretions.
Symptoms of Lassa fever include bleeding in the gums, nose, difficulty in breathing, cough, vomiting and diarrhea, hepatitis, swollen face, hearing loss, high or low blood pressure, tremors and other CNS conditions.
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Diagnostic tests for Lassa fever are laboratory-based. Lassa fever is diagnosed by using enzyme-linked immunosorbent serologic assays (ELISA). These detect IgM and IgG antibodies and Lassa antigens. Reverse transcription-polymerase chain reaction (RT-PCR) can also be used in the early stages of the disease. Immunohistochemistry stains performed on tissue specimens can be used to make a post-mortem diagnosis.
Rehydration and treatment of symptoms can improve the of survival if there is an early diagnosis. Intravenous ribavirin given early in the course of illness is an effective treatment, in addition to support of fluid and electrolytes, oxygenation, and blood pressure.
Major pharmaceutical companies are involved in the development of potential drug candidates to improve the Lassa Fever treatment such as EBS-Lassa, GEO-LM01, Lassa Fever Vaccine and others. Key players involved in the development of therapies to treat Lassa Fever are Curevac AG, Emergent BioSolutions Inc, GeoVax Labs Inc, Medigen Inc, Zalgen Labs LLC and others. One drug is under clinical-stage Phase I clinical trials and four drugs are in preclinical and some other drugs are under discovery stages of development.
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Report Covers the Emerging Pipeline Products Under Different Phases of Clinical Development Like:
- Late-stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I)
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
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