Acute Kidney Injury Pipeline Insight Report | 30+ Companies and 30+ Pipeline Therapies

DelveInsight's, "Acute Kidney Injury Pipeline Insight, 2023," report provides comprehensive insights about 30+ companies and 30+ pipeline drugs in Acute Kidney Injury pipeline landscape. It covers the Acute Kidney Injury pipeline drug profiles, including Acute Kidney Injury clinical trial and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

"Acute Kidney Injury takes place if the kidneys stop the filtration of the waste products from human blood. There are 25+ companies involved in the development of novel therapies for the treatment of acute kidney injury. The key players operating in the Acute Kidney Injury treatment market include Atox Bio, AM-Pharma, Angion Biomedica, Astellas Pharma, Guard therapeutics and several others"

Key takeaways from the Acute Kidney Injury Pipeline Report

• DelveInsight's Acute Kidney Injury Pipeline report depicts a robust space with 25+ active players working to develop 25+ pipeline therapies for Acute Kidney Injury treatment.

• Key Acute Kidney Injury companies include Atox Bio, AM Pharma Holding, Quark-Pharmaceuticals, LG Chem, Pharming Group, Angion Biomedica, Elysium Health, Sentien Biotechnologies, Pharmazz, Arch Biopartners, Guard Therapeutics, RegeneRx Biopharmaceuticals, Cerenis Therapeutics Alloksys, Vifor Pharma, Exponential Biotherapies, Astellas Pharma, Amniotics, Mission Therapeutics, Bessor pharma, Kantum Pharma, Nephraegis Therapeutics, Vasomune, Unicycive, ABIONYX and others are developing novel drug candidates to improve the Acute Kidney Injury treatment landscape.

• Promising Acute Kidney Injury pipeline therapies in various stages of development include bRESCAP, ANG-3777, EA-230, Ilofotase alfa, ASP1128, Ruconest (Conestat alfa), UMC 119 06, Kidney specific amniotic mesenchymal stem cell therapy, RMC 035, SBI-101, QPI-1002, RMC035, MIB-626, RBT-9, Recombinant human alkaline phosphatase, XRx-101, SUL-138, UNI494, Timbetasin, and others.

• The Acute Kidney Injury Companies and academics that are working to assess challenges and seek opportunities that could influence Acute Kidney Injury R&D. The Acute Kidney Injury pipeline therapies under development are focused on novel approaches to treat/improve the disease condition.

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Recent Developmental Activities in the Acute Kidney Injury Treatment Landscape

• In March 2022, at the 27th International Conference on Advances in Critical Care Nephrology, AM-Pharma will deliver an overview of the current Phase III REVIVAL study.

• In September 2021, AM-Pharma agreed to an exclusive licensing deal with Kyowa Kirin giving Kyowa Kirin the rights to develop and sell ilofotase alfa in Japan.

• Angion and Vifor publicly published findings on ANG-3777 clinical trials in 2021, including a Phase II CSA-AKI trial and a Phase III DGF trial.

• In December 2021, Researchers at the University of Groningen, the Netherlands and their collaborators, reported a lead compound for the treatment of Acute Kidney Injury (AKI). A new 6-chromanol-derived compound named SUL-138 being developed by Sulfateq BV has shown promise in animal models at treating acute kidney injury.

• In terms of development activities for CER-001, ABIONYX marked the continuation of the Phase IIa clinical study, called RACERS, to prevent acute kidney injury in high-risk septic patients, in partnership with the University of Bari.

• In February 2022, Renibus Therapeutics completed a USD 15 million extension as part of its Series A financing, led by family offices specializing in biotech investments, closing the round at USD 35 million. Proceeds from the financing will be used to advance Renibus' pipeline, including the company's lead candidates, RBT-1 for the prevention of acute kidney injury.

• In May 2021, Nephraegis Therapeutics, developing NPH-022 to prevent and treat Acute Kidney Injury (AKI) launched with a seed investment from Xontogeny, LLC to advance their lead compound through critical preclinical work.

• In December 2021, Altasciences has been chosen by XORTX Therapeutics Inc. to conduct a pharmacokinetic bridging study in support of the XRx-008 program for autosomal dominant polycystic kidney disease (ADPKD), and XRx-101 for acute kidney injury associated with COVID-19.

• In June 2021, KBI Biopharma entered into a manufacturing agreement with AM Pharma, particularly concerning to AM Pharma's recAP program potentially being investigated for the treatment of sepsis-associated acute kidney injury.

Acute Kidney Injury Overview

Acute kidney injury (AKI), also known as acute renal failure (ARF), is a sudden episode of kidney failure or kidney damage that happens within a few hours or a few days. AKI causes a build-up of waste products in your blood and makes it hard for your kidneys to keep the right balance of fluid in your body. AKI can also affect other organs such as the brain, heart, and lungs. Acute kidney injury is common in patients who are in the hospital, in intensive care units, and especially in older adults. There are rarely any symptoms until the condition has progressed to a late stage. However, if there are symptoms, the most common one is a decrease in urine output. Doctors diagnose acute kidney injury by measuring the level of creatinine in the blood. (Creatinine is a chemical waste product removed by the body entirely by the kidneys. If the kidneys are not working properly, there will be an increase in levels in the blood).

Acute Kidney Injury Emerging Drugs

• RMC-035: GUARD THERAPEUTICS
Guard Therapeutics is developing RMC-035 (ROSgard), a biological drug candidate that utilizes one of the body's most powerful and universal protections against oxidative stress. RMC-035 is naturally designed to "target" the kidneys, allowing RMC-035 to be present when the kidneys are attacked by oxidative stress. Treatment with RMC-035 has the potential to save lives and prevent the risk of both acute and chronic kidney damage with subsequent serious consequences due to impaired kidney function, such as life-sustaining dialysis treatment. Currently, it is in Phase II stage of clinical trial evaluation to treat Acute Kidney Injury.

• RBT-1: Rénibus Therapeutics
Rénibus' lead product, RBT-1, is a novel pharmacologic intervention combining stannous protoporphyrin and iron sucrose, induces a preconditioning protective effect on the kidney and other organs, upregulating production of protective proteins to prevent post-operative complications following cardiothoracic surgery, including AKI, days in the ICU, time on ventilator, and hospital readmission rates. Pre-clinical and Phase I development is complete, and RBT-1's Phase II trial a Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of RBT-1 on Preconditioning Response Biomarkers in Subjects Undergoing Coronary Artery Bypass Graft (CABG) and/or Cardiac Valve Surgery (The START Study) was initiated in April 2021 and is expected to be completed in Q4 2022. A pre-specified interim analysis was conducted following the enrollment of the first 60 patients, yielding statistically significant results in both the primary and several secondary endpoints.

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Acute Kidney Injury Therapeutic Assessment

There are approx. 30+ key companies which are developing the therapies for Acute Kidney Injury. The companies which have their Acute Kidney Injury drug candidates in the most advanced stage, i.e. phase II include, GUARD THERAPEUTICS.

Acute Kidney Injury Segmentation
The Acute Kidney Injury Pipeline report proffers an integral view of the Acute Kidney Injury emerging novel therapies segmented by Stage, Product Type, Molecule Type, Mechanism of Action, and Route of Administration.

Learn more about the novel and emerging Acute Kidney Injury pipeline therapies, visit Acute Kidney Injury Ongoing Clinical Trials Analysis @ https://www.delveinsight.com/report-store/acute-kidney-injury-aki-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Scope of the Acute Kidney Injury Pipeline Report

• Coverage- Global

• Acute Kidney Injury Companies- Atox Bio, AM Pharma Holding, Quark-Pharmaceuticals, LG Chem, Pharming Group, Angion Biomedica, Elysium Health, Sentien Biotechnologies, Pharmazz, Arch Biopartners, Guard Therapeutics, RegeneRx Biopharmaceuticals, Cerenis Therapeutics Alloksys, Vifor Pharma, Exponential Biotherapies, Astellas Pharma, Amniotics, Mission Therapeutics, Bessor pharma, Quantum Pharma, Nephraegis Therapeutics, Vasomune, Unicycive, ABIONYX and others.

• Acute Kidney Injury Pipeline Therapies- bRESCAP, ANG-3777, EA-230, Ilofotase alfa, ASP1128, Ruconest (Conestat alfa), UMC 119 06, Kidney specific amniotic mesenchymal stem cell therapy, RMC 035, SBI-101, QPI-1002, RMC035, MIB-626, RBT-9, Recombinant human alkaline phosphatase, XRx-101, SUL-138, UNI494, Timbetasin, and others.

• Acute Kidney Injury Segmentation: Phases, Product Type, Mechanism of Action, Route of Administration, Molecule Type

Table of Content
1. Introduction
2. Executive Summary
3. Acute Kidney Injury: Overview
4. Acute Kidney Injury Pipeline Therapeutics
5. Acute Kidney Injury Therapeutic Assessment
6. Acute Kidney Injury - DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Drug name: Company name
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. RMC-035: GUARD THERAPEUTICS
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I/II)
14. SBI 101 - Sentien Biotechnologies
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. ILB-202: ILIAS Biologics
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Acute Kidney Injury Key Companies
21. Acute Kidney Injury Key Products
22. Acute Kidney Injury- Unmet Needs
23. Acute Kidney Injury- Market Drivers and Barriers
24. Acute Kidney Injury- Future Perspectives and Conclusion
25. Acute Kidney Injury Analyst Views
26. Acute Kidney Injury Key Companies
27. Appendix

Dive deep into rich insights for drugs for Acute Kidney Injury, visit Acute Kidney Injury Key Companies and Therapies @ https://www.delveinsight.com/report-store/acute-kidney-injury-aki-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

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