Checkpoint Inhibitor Refractory Cancer Market Outlook 2032 | Key Assessment into the Epidemiology Trends, Evolving Market Dynamics, Ongoing Therapeutic Developments, Emerging Therapies, and Key Players by DelveInsight

As per DelveInsight, the Checkpoint Inhibitor Refractory Cancer Market size is anticipated to grow in the coming years owing to the increase in R&D activity, rise in the cases of a different type of cancers where checkpoint inhibitors are in use, expected commercial success of upcoming therapies which are going to resolve the issue of primary resistance, along with a hike in the usage of approved checkpoint inhibitor therapies in the 7MM.

Companies across the globe are thoroughly working toward developing new drug therapy options to treat a wide array of Checkpoint-Inhibitor Refractory Cancers. Some of the key players, such as Mirati Therapeutics, BerGenBio, OncoSec Medical, CatalYm, Checkmate Pharmaceuticals, and others, are involved in developing novel therapies for indications such as advanced-stage, solid tumors, non-small cell lung cancer (NSCLC), Melanoma and others.

DelveInsight's "Checkpoint Inhibitor Refractory Cancer Market Insights, Epidemiology, and Market Forecast 2032" report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Checkpoint Inhibitor Refractory Cancer Market Size and Share in the 7MM (i.e., the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan).

The Checkpoint Inhibitor Refractory Cancer market report covers emerging drugs, treatment practices, market share of individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current treatment practice/algorithm, market drivers & barriers, and unmet medical needs to curate the best of opportunities and assess the underlying potential of the market.

Checkpoint Inhibitor Refractory Cancer: An Overview
Over the last decade, a major achievement in cancer research has been introducing immune checkpoint inhibitors in treatment. Anti-PD1/PDL1 antibodies are among the most widely prescribed anticancer therapies. Checkpoint inhibitors are now used as single agents or combined with chemotherapies as the first or second lines of treatment for about 50 cancer types.

Immune checkpoints are a normal part of the immune system. Their role is to prevent an immune response from being so strong that it destroys healthy cells in the body. However, in case of cancer, when the checkpoint and partner proteins bind together, they send an "off" signal to the T cells. This prevents the immune system from destroying cancer.

Immune checkpoint inhibitors are drugs that block immune checkpoints. These drugs allow immune cells to respond more strongly to cancer by blocking them. This prevents the "off" signal from being sent, allowing the T-cells to kill cancer cells. A wide range of cancer types can be treated using checkpoint inhibitors, for example, lung cancer (NSCLC and SCLC), melanoma, breast cancers (triple-negative, metastatic breast cancer), Hodgkin lymphoma, Urothelial carcinoma, Renal cell cancer (RCC) and several others. Immune checkpoint inhibitors provide an edge over other generally used treatment therapies like chemotherapy, as they possess greater survival time and high potency against cancer cells.

Checkpoint Inhibitor Refractory Cancer Market Key Facts
- As per DelveInsight, the Checkpoint Inhibitor Refractory Cancer market size in the seven major markets was USD 11.5 million in 2020, which is expected to grow by 2032.
- The total number of incident cases of Checkpoint Inhibitor Refractory Cancer-associated in 7MM countries was 156,000+ in 2020.
- A cross-sectional study by Haslam and Prasad (2019) found that the estimated percentage of US patients with cancer who are eligible for checkpoint inhibitor drugs increased from 1.54% in 2011 to 43.63% in 2018. The percentage of patients estimated to respond to checkpoint inhibitor drugs was 0.14% in 2011 and increased to 12.46% in 2018.

Checkpoint Inhibitor Refractory Cancer Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted Checkpoint Inhibitor Refractory Cancer market size by analyzing the impact of current and emerging therapies in the market. It also provides a detailed assessment of the market drivers & barriers, unmet needs, and emerging technologies.

The report gives complete detail of the Checkpoint Inhibitor Refractory Cancer market trend for each marketed drug and late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action (MoA), competition with other therapies, brand value, their impact on the market and view of the key opinion leaders.

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Checkpoint Inhibitor Refractory Cancer Epidemiology
The epidemiology section covers detailed insights into the historical and current Checkpoint Inhibitor Refractory Cancer patient pool and forecasted trends for every seven major countries (7MM) from 2019 to 2032.

The Report Covers the Checkpoint Inhibitor Refractory Cancer Epidemiology Segmented by -
- Total Incidence cases of cancer type (Melanoma, Lung cancer, Lymphomas, kidney cancer, and others) where Checkpoint inhibitors are currently being used in the 7MM (2019-32)
- Total Checkpoint Inhibitor usage in each cancer type in the 7MM (2019-32)
- Total Stage-specific cases by cancer type in the 7MM (2019-32)
- Total Checkpoint Inhibitor treated patient pool in each cancer type in the 7MM (2019-32)
- Total Checkpoint Inhibitor Refractory cases in each cancer type in the 7MM (2019-32)

Checkpoint Inhibitor Refractory Cancer Drugs Uptake and Pipeline Development Activities
The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the Checkpoint Inhibitor Refractory Cancer market or expected to get launched in the market during the study period. The analysis covers Checkpoint Inhibitor Refractory Cancer market uptake by drugs, patient uptake by therapies, and sales of each drug.

Report's Drugs Uptake section helps in understanding the drugs with the most rapid uptake and reasons behind the maximal use of new drugs and allows the comparison of the drugs based on market share and size, which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

The report also covers the Checkpoint Inhibitor Refractory Cancer Pipeline Development Activities and provides valuable insights about different therapeutic candidates in Phase II and Phase III stages and the key companies in the market involved in developing targeted therapeutics. It also analyses recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

Checkpoint Inhibitor Refractory Cancer Therapeutics Assessment
Some of the major pharma and biotech giants such as 4D pharma plc., 4SC AG, Ascentage Pharma Group, AstraZeneca, BerGenBio, Bristol-Myers Squibb, CatalYm, Checkmate Pharmaceuticals, Eisai, ENB Therapeutics, Inc., Evelo Biosciences, Inc., Exelixis, Exicure, Inc., Genentech/Hoffmann-La Roche, ImmunityBio, Janssen Research and Development, LLC, Kartos Therapeutics, Merck, Mirati Therapeutics, OncoSec Medical, Pfizer, Regeneron Pharmaceuticals, and others are actively working in the Checkpoint Inhibitor Refractory Cancer Therapeutics Market.

Checkpoint Inhibitor Refractory Cancer Emerging Drug Covered in the Report Include:
- MRx0518: 4D pharma plc
- Domatinostat (4SC-202): 4SC AG
- Sitravatinib: Mirati Therapeutics
- CTL-002: CatalYm
- Bemcentinib + Pembrolizumab: BerGenBio
- CMP-001 + Nivolumab: Checkmate Pharmaceuticals
- TBX-3400: Taiga
And many more

Presently, a decent number of combinational therapies are under investigation for several checkpoint-inhibitor refractory cancers. The outlook for these treatments is promising. Clinical trials for these therapies have been fairly positive regarding safety and efficacy. The results of these studies are encouraging further investigation into multiple cancer types. The current scenario also anticipates a positive shift in the market for the forecast period.

Learn More About the Emerging Therapies & Key Companies in the Checkpoint Inhibitor Refractory Cancer Therapeutics Market:
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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Checkpoint Inhibitor Refractory Cancer Competitive Intelligence Analysis
4. Checkpoint Inhibitor Refractory Cancer Market Overview at a Glance
5. Checkpoint Inhibitor Refractory Cancer Background and Overview
6. Checkpoint Inhibitor Refractory Cancer Patient Journey
7. Checkpoint Inhibitor Refractory Cancer Epidemiology and Patient Population
8. Checkpoint Inhibitor Refractory Cancer Treatment Algorithm, Current Treatment, and Medical Practices
9. Checkpoint Inhibitor Refractory Cancer Unmet Needs
10. Key Endpoints of Checkpoint Inhibitor Refractory Cancer Treatment
11. Checkpoint Inhibitor Refractory Cancer Marketed Products
12. Checkpoint Inhibitor Refractory Cancer Emerging Therapies
13. Checkpoint Inhibitor Refractory Cancer Seven Major Market Analysis
14. Attribute Analysis
15. Checkpoint Inhibitor Refractory Cancer Market Outlook (7 major markets)
16. Checkpoint Inhibitor Refractory Cancer Access and Reimbursement Overview
17. KOL Views on the Checkpoint Inhibitor Refractory Cancer Market.
18. Checkpoint Inhibitor Refractory Cancer Market Drivers
19. Checkpoint Inhibitor Refractory Cancer Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

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