Graft Versus Host Disease (GVHD) - Drug Pipeline Landscape, 2022

Graft Versus Host disease (GVHD) is an immune mediated systemic disorder associated with complex interaction between donor and recipient adaptive immunity. It is a common complication after hematopoietic stem cell transplant (HCT), here the graft recognizes the host as a foreign and attack the recipient's body cell. GvHD is of two types: acute GvHD - which develops within 100 days of transplantation and chronic GvHD - which develops after 100 days of transplantation.

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GvHD occurs after the bone marrow transplants and stem cell transplants. Following are the other occurrences of GvHD - allogenic bone transplantation, solid organs that are rich in lymphoid cells and un-irradiated blood.

Symptoms of GvHD range from mild to severe. Common acute symptoms include abdominal pain or cramps, nausea, vomiting, diarrhoea, jaundice, skin rash, itching, redness on areas of the skin and increased risk for infections. Chronic symptoms include dry eyes, burning sensation, fatigue, joint pains, shortness of breath, wight loss, etc.,

GvHD is diagnosed through imaging - X-ray abdomen, CT scan abdomen and chest, PET scan and MRI. Other diagnosis involves liver function tests, liver biopsy and capsule endoscopy.

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Key Players
9 Meters Biopharma Inc
Abbisko Cayman Limited
Accro BioScience (Suzhou) Co Ltd
Actitrexx GmbH
Adienne Pharma & Biotech SA
Alphamab Oncology
AltruBio Inc
Amcyte Pharma Inc
AnaMar AB
AnaptysBio Inc
ASC Therapeutics Inc
AstraZeneca Plc
Avalon GloboCare Corp

Report Segmentation
Assessment by Stage of Development
Assessment by Companies
Assessment by Target
Assessment by Mechanism of Action
Assessment by Molecule Type
Assessment by Route of Administration

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Methodology
The research process includes extensive secondary research on public domain and other authentic sources to add or update the pipeline products information. The secondary research sources include, but are not limited to company websites, annual reports, financial reports, company pipeline chart, investor presentations and SEC filings, journals and conferences, and clinical trials registries.

Scope
The pipeline landscape report provides analysis of pipeline products based on several stages of development ranging from Discovery to Pre-Registration. The report provides a review of pipeline therapeutics by companies based on information derived from company and industry-specific sources.

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