Follicular Lymphoma Pipeline Appears Robust With 50+ Key Pharma Companies Actively Working in the Therapeutics Segment | DelveInsight

DelveInsight's, "Follicular Lymphoma Pipeline Insight, 2022," report provides comprehensive insights about 50+ companies and 50+ pipeline drugs in Follicular Lymphoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

In the Follicular Lymphoma Pipeline Report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Follicular Lymphoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Key takeaways from the Follicular Lymphoma Pipeline Report
• DelveInsight's Follicular Lymphoma Pipeline analysis depicts a robust space with 50+ active players working to develop 50+ pipeline treatment therapies.
• The leading Follicular Lymphoma Companies are working such as Merck & Co, Genentech, Incyte Corporation, Syndax Pharmaceuticals, Dr Reddy's Laboratories, Novartis, ADC Therapeutics, Xynomic Pharmaceuticals, Cho Pharma Inc., Janssen, XEME Biopharma Inc., Shanghai Yingli Pharmaceutical, Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Beijing Mabworks Biotech Co., Ltd., Archigen Biotech, Hutchison Medipharma Limited, Nordic Nanovector, Xynomic Pharmaceuticals, TG Therapeutics, BeiGene, Allogene Therapeutics, MEI Pharma, Inc., Pfizer, Innovent Biologics (Suzhou) Co. Ltd., Enterome, AstraZeneca, Nanjing Sanhome Pharmaceutical, Co., Ltd., Takeda, Bristol-Myers Squibb, TCR2 Therapeutics, and others.
• Promising Follicular Lymphoma Pipeline therapies such as Mosunetuzumab, Tafasitamab, Pembrolizumab, Zanubrutinib, and others.
• The companies and academics are working to assess challenges and seek opportunities that could influence Follicular Lymphoma R&D. The therapies under development are focused on novel approaches to treat/improve Follicular Lymphoma.

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Follicular Lymphoma Overview
Follicular lymphoma (FL) is typically a slow-growing or indolent form of non- Hodgkin lymphoma (NHL) that arises from B-lymphocytes, making it a B-cell lymphoma. This lymphoma subtype accounts for 20 to 30 percent of all NHL cases. Common symptoms of FL include enlargement of the lymph nodes in the neck, underarms, abdomen, or groin, as well as fatigue, shortness of breath, night sweats, and weight loss. Often, patients with FL have no obvious symptoms of the disease at diagnosis. Follicular lymphoma is usually not considered to be curable, but more of a chronic disease. Patients can live for many years with this form of lymphoma. Follicular lymphoma is a B-cell lymphoma. It is characterized by the transformation of a B-cell into a malignant (cancerous) cell. Abnormal, uncontrolled growth and multiplication (proliferation) of malignant B-cells can lead to enlargement of specific lymph node regions; involvement of other lymphatic tissues such as the spleen or bone marrow; and spread to other bodily tissues and organs. The term follicular lymphoma comes from the observation that the cancer cells are group in clusters (or follicles) within the lymph nodes. Non-Hodgkin lymphoma including follicular lymphoma can be characterized as "low-grade" (or indolent), meaning the cancer tends to grow slowly and results in few associated symptoms or "high-grade" (aggressive), meaning the cancer typically grows rapidly. The exact, underlying cause of follicular lymphoma is not fully understood. The reason why cancer develops is a complex question and researchers speculate that multiple factors are involved in the development of follicular lymphoma. These factors include genetic, environmental and immunologic factors, which all may play a role in the development of this cancer.

Recent Developmental Activities in the Follicular Lymphoma Market
• Mosunetuzumab (Anti-CD20 x CD3 TDB, RG7828) is a humanized full-length T cell-dependent bispecific antibody designed to target both CD20 on B cells and CD3 on T cells. This dual-targeting antibody is designed to redirect T cells to attack cancer cell. Mosunetuzumab is a CD20xCD3 T-cell engaging bispecific antibody with monovalent binding to CD20 and monovalent binding to CD3 (1:1 format).The drug is currently in phase 3 stage of development for the treatment of Follicular Lymphoma.
• Tafasitamab is a humanized Fc-modified cytolytic CD19 targeting monoclonal antibody. In 2010, MorphoSys licensed exclusive worldwide rights to develop and commercialize tafasitamab from Xencor, Inc. Tafasitamab incorporates an XmAb® engineered Fc domain, which mediates B-cell lysis through apoptosis and immune effector mechanism including antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).
• Pembrolizumab is a monoclnal antibody that binds to and blocks PD-1 located on lymphocytes. This receptor is generally responsible for preventing the immune system from attacking the body's own tissues; it is a so-called immune checkpoint. Normally, the PD-1 receptor on activated T-cells binds to ligands PD-L1 or PD-L2 on other cells, deactivating a potential T-cell-mediated immune response against normal cells in the body. Currently, it is in phase II stage of development to treat Follicular lymphoma.
• Zanubrutinib (BGB-3111) - a small molecule inhibitor of Bruton's tyrosine kinase, or BTK, that is currently being evaluated in a broad late-stage clinical trials program globally, including in China, as a potential monotherapy and in combination with other therapies to treat various B cell malignancies. BTK is a key component of the B-cell receptor, or BCR, signaling pathway and is an important regulator of cell proliferation and cell survival in various B cell malignancies. BTK inhibitors block BCR-induced BTK activation and its downstream signaling, leading to growth inhibition and cell death in certain malignant white blood cells called B-cells. Zanubrutinib is an orally active inhibitor that covalently binds to BTK, resulting in irreversible inactivation of the enzyme.

Follicular Lymphoma Emerging Drugs
• Mosunetuzumab - Genentech
• Tafasitamab - Incyte Corporation
• Pembrolizumab: Merck & Co
• Zanubrutinib - BeiGene

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Follicular Lymphoma Pipeline Therapeutic Analysis
There are approx. 50+ key companies which are developing the therapies for Follicular Lymphoma. The companies which have their Follicular Lymphoma drug candidates in the most advanced stage, i.e. phase III include, Genetech.

Scope of the Follicular Lymphoma Pipeline Report
• Coverage- Global
• Follicular Lymphoma Therapeutic Assessment by Product Type
• Follicular Lymphoma Assessment by Stage and Product Type
• Follicular Lymphoma Assessment by Route of Administration
• Follicular Lymphoma Assessment by Stage and Route of Administration
• Follicular Lymphoma Assessment by Molecule Type
• Follicular Lymphoma Assessment by Stage and Molecule Type
• Follicular Lymphoma Companies- Merck & Co, Genentech, Incyte Corporation, Syndax Pharmaceuticals, Dr Reddy's Laboratories, Novartis, ADC Therapeutics, Xynomic Pharmaceuticals, Cho Pharma Inc., Janssen, XEME Biopharma Inc., Shanghai Yingli Pharmaceutical, Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Beijing Mabworks Biotech Co., Ltd., Archigen Biotech, Hutchison Medipharma Limited, Nordic Nanovector, Xynomic Pharmaceuticals, TG Therapeutics, BeiGene, Allogene Therapeutics, MEI Pharma, Inc., Pfizer, Innovent Biologics (Suzhou) Co. Ltd., Enterome, AstraZeneca, Nanjing Sanhome Pharmaceutical, Co., Ltd., Takeda, Bristol-Myers Squibb, TCR2 Therapeutics, and others
• Follicular Lymphoma Pipeline therapies- Mosunetuzumab, Tafasitamab, Pembrolizumab, Zanubrutinib, and others

Table of content
1. Introduction
2. Executive Summary
3. Follicular Lymphoma: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Follicular Lymphoma- DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Mosunetuzumab - Genentech
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. Pembrolizumab: Merck &Co.
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I/II)
14. Drug name: Company name
15. Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
16. Drug name: Company Name
17. Drug profiles in the detailed report…..
18. Inactive Products
19. Follicular Lymphoma Key Companies
20. Follicular Lymphoma Key Products
21. Follicular Lymphoma- Unmet Needs
22. Follicular Lymphoma- Market Drivers and Barriers
23. Follicular Lymphoma- Future Perspectives and Conclusion
24. Follicular Lymphoma Analyst Views
25. Follicular Lymphoma Key Companies
26. Appendix

Key Questions
Current Treatment Scenario and Emerging Therapies:
• How many companies are developing Follicular Lymphoma drugs?
• How many Follicular Lymphoma drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Follicular Lymphoma?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Follicular Lymphoma therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Follicular Lymphoma and their status?
• What are the key designations that have been granted to the emerging drugs?

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