Mice Model Technologies Market Outlook, Competitive Landscape and Forecasts to 2031

Mice Model Technologies Market Outlook 2031

-The global mice model technologies market was valued at US$ 1.6 Bn in 2021
-The global market is projected to grow at a CAGR of 7.4% from 2022 to 2031
-The global mice model technologies market is anticipated to reach US$ 3.2 Bn by 2031

Global Mice Model Technologies Market Introduction

Animal model is a non-human species, which can mimic characteristics of a biological process or a disease found in humans. Animal models are used in biomedical research. Genetic engineering is used to develop different types of mice models to target specific human diseases. Mice model technologies are often adopted in biomedical research, as mice share mammalian features with humans and suffer from many similar diseases.

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Surge in Investment in Biomedical Research to Drive Demand for Mice Model Technologies

Investment in biomedical research is considered one of the most important indicators of any country's research landscape. In the last decade, biomedical research expenditure has increased manifold across the globe, with developed countries such as the U.S. and the U.K. dominating the landscape. Majority of these investments are made for R&D of animal models.

The National Institutes of Health (NIH), the largest advocate of biomedical research in the world, had a budget of around US$ 31 Bn in 2019, followed by the Bill & Melinda Gates Foundation (BMGF) and the Wellcome Trust (each with approximately US$ 1.08 Bn; 3.1%). Overall, around 89.6% (approximately US$ 32 Bn) of all the grants awarded for biomedical research were allocated to recipient organizations in the U.S. More than 60% of NIH extramural funding involves animal-related research; most of this is allocated to mice-related studies. Thus, increase in biomedical research funding is expected to drive the global mice model technologies market during the forecast period.

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Rise in Adoption of Advanced Genomic Techniques

Various techniques and methodologies have been developed in the past few years to create genetically modified mice models of human diseases. Homologous recombination in embryonic stem cells is the conventional way of gene targeting. The advent of new molecular genome-altering technologies such as CRISPR/Cas9 allows for genetic mutations to be introduced into the germ line of a mouse faster and cheaper than previous methods.

Development of mice models is significantly easier than before with the use of CRISPR-based techniques. These techniques can be employed to effectively and quickly (within two to three months) produce frequently used mice models (simple knockout mouse, CRISPR Knockin mouse, point mutation knock-in mouse, cKOs, and reporter/Cre knock-ins). One or two guide RNAs and Cas9 protein can be injected to generate knockout mice. Development of large knock-ins (approximately 5 to 10 kb long) is generally achieved using plasmid DNAs as donors. CRISPR editing or ESC-mediated gene targeting can be used to create humanized knock-in (KI) mice models; each technique has its advantages for model development.

Cyagen TurboKnockout gene targeting service combines benefits of each approach to enable sophisticated gene modeling in C57BL/6 or BALB/c mouse models on an accelerated timeframe, including LFKIs up to 300 kb. In as little as six months, TurboKnockout can provide research-ready mouse models for humanization.

High Efficiency of CRISPR Gene Editing Technology Boosting CRISPR Knockout Segment

In terms of technology, the global mice model technologies market has been segregated into CRISPR Knockout; CRISPR Knockin; random insertions, large, targeted insertions; ES cell modification (homologous recombination); and others. The CRISPR Knockout segment held dominant share of the market in 2021. It is expected to maintain its dominance during the forecast period. Growth of the segment can be ascribed to high efficiency of CRISPR gene editing technology and increase in adoption of CRISPR technology for the development of CRISPR Knockout mice.

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Increase in Adoption of CRISPR Technology in Biotechnology Companies

Based on end-user, the global mice model technologies market has been classified into pharmaceutical companies, biotechnology companies, academic and research facilities, and contract research and manufacturing organizations.

The biotechnology companies segment is projected to account for dominant share of the global mice model technologies market during the forecast period. Increase in adoption of CRISPR technology in biotechnology companies and research laboratories is driving the segment. For instance, in October 2016, Caribou Biosciences granted The Jackson Laboratory non-exclusive worldwide rights to use its CRISPR-Cas9 intellectual property to create genetically-engineered mice for research purposes.

The academic and research facilities segment is expected to grow at a higher rate during the forecast period. Growth of the segment can be ascribed to the rise in funding for academic and research facilities for R&D in mice model technologies.

Regional Outlook of Global Mice Model Technologies Market

North America dominated the global mice model technologies market, with more than 40% share in 2021. According to the mice model technologies market research study, rise in research and development activities in CRISPR to provide modified products for prevention and treatment of various chronic and rare diseases, such as sickle cell anemia and Alzheimer's diseases, is expected to fuel the market in North America in the near future.

Asia Pacific is also poised to witness significant growth during the forecast period, owing to the increase in adoption of mice models for R&D in COVID-19 prevention and treatment.

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Analysis of Key Players in Global Mice Model Technologies Market

The global mice model technologies market is fragmented, with the presence of international as well as local players. Manufacturers in the market are striving to build a strong network of vendors to enable seamless distribution of products. Players are also focused on adopting strategies such as collaboration, partnership, joint venture, and merger and acquisition to enhance their mice model technologies market share.

Key players operating in the global mice model technologies market include Biocytogen, Charles River Laboratories, Cyagen Biosciences, Gempharmatech, GenOway, Ingenious Targeting Laboratory, Merck KGaA, Ozgene Pty Ltd., Taconic Biosciences, Inc., PolyGene AG, The Jackson Laboratory, Yale School of Medicine, University of North Carolina, University of Nebraska Medical Center, Monash University, UMass Chan Medical School, University of Bonn, Columbia University, and The University of Arizona.

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