Critical Limb Ischemia Treatment Market Analysis and Forecast up to 2031

Critical Limb Ischemia Treatment Market Introduction

Critical limb ischemia (CLI) is a severe peripheral arterial disease (PAD), wherein chronic inflammation associated with atherosclerosis (progressive thickening of artery lining) causes reduced blood flow to the extremities (legs, feet, and hands), leading to severe pain and ulcers or sore. Major risk factors for critical limb ischemia are age (people aged 60 or over are at high risk of developing this diseased condition), obesity, diabetes, high cholesterol level, smoking, sedentary lifestyle, and high blood pressure. Critical limb ischemia is associated with symptoms such as ischemic rest pain, gangrene, or tissue loss. Rise in prevalence of critical limb ischemia is anticipated to increase the demand for therapeutics, thereby driving the global chronic limb ischemia treatment market. Furthermore, growth in health care expenditure and rise in number of clinical trials are likely to propel the global chronic limb ischemia treatment market. Increase in patient population with critical limb ischemia, growth of the pharmaceutical industry, improvement in health care infrastructure, and surge in number of clinical trials are also projected to be the key drivers of the global market.

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Impact of COVID-19 on Critical Limb Ischemia Treatment Market

The COVID-19 pandemic has had a negative impact on the global critical limb ischemia treatment market. This is despite the fact that a large percentage of population in some regions has been vaccinated with all the required jabs. Governments of affected countries deferred non-essential surgeries and patient visits during the breakout year of the pandemic. This led to a decline in overall critical limb ischemia diagnosis and treatments in hospitals and clinics. Limited understanding of the epidemiology and etiology of the disease is a key factor that has constrained the development of effective therapeutic options. Thus, leading players in the critical limb ischemia treatment market reported a decline in revenue due to the pandemic. However, the market has been recovering from COVID-19 due to the easing of restrictions by governments across the globe.

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Rise in Preference for Revascularization to Treat Critical Limb Ischemia

In terms of treatment, the devices segment is projected to account for dominant share of the global critical limb ischemia treatment market during the forecast period. Dilation devices and stents provide dilation effectively and protect the artery wall. These are the frequently used devices in the treatment for critical limb ischemia. Dilation devices and stents also offer low complication rates and high technical success, leading to a better quality of life for patients. These advantages are projected to drive the devices segment during the forecast period. The segment's dominance can also be ascribed to the increase in FDA approval and patient preference for revascularization as the first line of treatment. Recently, optimized balloon angioplasty study of the Tack Endovascular System in Below the Knee Arteries (TOBA II BTK) has shown positive results in clinical trials.

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Increase in Usage of Balloon Dilators and CLI Vascular Surgery to Drive Demand for Peripheral Dilatation Systems

The devices segment has been bifurcated into embolic protection devices and peripheral dilatation systems. The peripheral dilatation systems sub-segment is projected to account for major share of the devices segment during the forecast period. This can be ascribed to the increase in usage of balloon dilators and CLI vascular surgery. Leading players in the critical limb ischemia treatment market are focusing on the development and launch of technologically advanced peripheral dilatation devices. In June 2022, Cordis, a global leader in cardiovascular technologies, announced the human use of the Radianz Radial Peripheral System. The Radianz Radial Peripheral System solution includes BRITE TIP RADIANZTM Guiding Sheath used to optimize lower extremity lesion access, the SABERX RADIANZTM PTA Catheter to facilitate treatment, and the S.M.A.R.T. RADIANZTM Vascular Stent System to help maintain patency for lasting favorable outcomes.

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High Preference for Antiplatelet Drugs to Treat Critical Limb Ischemia

The antiplatelet drugs sub-segment accounted for leading share of the medications segment in 2021. The sub-segment is projected to lose market share from 2022 to 2031. The antiplatelet drugs sub-segment is anticipated to grow at the fastest CAGR during the forecast period. Antiplatelet drugs are widely used in the treatment of critical limb ischemia and are easily available in retail stores. Additionally, major pharmaceutical manufacturers are focusing on the development of new antiplatelet drugs for the treatment of critical limb ischemia. This is likely to propel the critical limb ischemia treatment market size during the forecast period.

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Regional Outlook of Global Critical Limb Ischemia Treatment Market

North America is projected to dominate the global critical limb ischemia treatment market in the next few years. The market in the region is expected to grow at a moderate CAGR during the forecast period. This can be ascribed to the increase in government initiatives and awareness about CLI and other risk-associated disorders, rise in healthcare expenditure, surge in disposable income, and the availability of technologically advanced devices in the region. According to a recent study, around 2 million to 3 million people suffer from critical limb ischemia in the U.S.

The market in Asia Pacific is anticipated to grow at a high CAGR from 2022 to 2031. The critical limb ischemia treatment market in the region is driven by the rise in prevalence of CLI in countries such as India and China, increase in geriatric population, surge in health care spending, and government initiatives. Large population, unmet medical needs, and rise in patient awareness are anticipated to propel the market in the region. Economic growth in emerging economies such as India and China is enhancing the purchasing capabilities of consumers due to the increase in disposable income. This is likely to augment the market in these countries in the near future.

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