Tangential Flow Filtration for Selective Purification of Proteins

In 2021, the global tangential flow filtration market accounted for $1,237.6 million, which is on the path to hit $3,667.2 million revenue by 2030, growing at a 12.8% CAGR from 2021 to 2030. The market is being driven by the expansion of the biopharmaceutical sector, especially the growth of biosimilars and biologics production; increasing investment in research & development by industry players; and the benefits of tangential flow filtration above normal flow filtration.

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Furthermore, tangential flow filtration may be the ideal solution when impurity removal must be efficient and cost-effective while also involving a significant volume of sample. tangential flow filtration separates or isolates certain particle sizes using a filter. In contrast to classical filtration, the fluid is cycled over the filter rather than being driven through it, creating a pressure difference. The system is completely operational after the setup is complete and the sample is in the reservoir. Moreover, tangential flow filtration separates and purifies biomolecules quickly and continuously.

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Furthermore, the two main methods used in tangential flow filtration are ultrafiltration and microfiltration. The ultrafiltration category holds over 65% share of the market, because it helps in decreasing the biopharmaceutical products's manufacturing costs. General Biol, a Chinese pharmaceutical company, recently collaborated with Cytiva to produce oligonucleotides using the company's integrated FlexFactory single-use technology. The platform consists of the KTA Process explosion-proof purification system, the OligoProcess nucleic acid synthesis system, and the Uniflux explosion-proof tangential flow ultrafiltration system.

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