Customized Therapy for Breast Cancer PatientsResearchers in the VPH-PRISM project develop new procedures to improve treatment of breast cancer using multidisciplinary image data.
Every tenth woman is afflicted with breast cancer during her lifetime.The diagnosis and treatment of a patient involves the collaboration of a wide range of specialists. The broad range of software platforms for storage and visualization of medical imaging data used by radiologists, pathologists, oncologists, radiotherapists and surgeons, brings challenges for communication and data transfer between the platforms. Improved extraction and transfer of information between the platforms may support breast cancer diagnosis and therapy planning.
This is where the VPH-PRISM project comes into play. Eight research partners and one coordinating partner are developing novel software systems that intelligently connect medical data sets to allow innovative assistive functions. The researchers plan to combine image data generated by various diagnostic procedures (X-ray, MRI, tissue histology) for display in a single software application. Their vision consists of systematically gathering and quantitatively combining the image information currently available from various disciplines. For the first time, this would permit a large number of microscopic and macroscopic tissue parameters to be correlated efficiently and precisely. This could provide important indicators, enabling clinicians to customize therapy planning for individual patients.
To realize this, researchers in the project intend to create an interactive database to connect images with other relevant information, such as a patient’s risk of hereditary disease and environmental factors. This database would allow development of more focused therapy for breast cancer patients in the future. The Fraunhofer Institute for Medical Image Computing MEVIS in Bremen has taken charge of the scientific coordination of the project and is responsible for developing significant sections of the required image analysis procedures.
Early detection and therapy for breast cancer typically involves multiple disciplines. Radiologists interpret X-ray and MRI scans of the patient breast, whereas pathologists use 40x magnification and higher to examine the spatial arrangement of single cells from breast tissue samples. Surgeons attempt to remove malignant tumors effectively while conserving as much healthy tissue as possible. Radiotherapists treat breast cancer with radiation, and oncologists decide which type of chemotherapy is expected to be most beneficial.
An important challenge is to increase the interconnectivity of the information technology systems of these different disciplines. Radiologists and pathologists often work in the same hospital with different IT systems, each partly optimized to display and manipulate only the specialists’ own image data. When experts from different fields discuss suitable therapies, different image storage systems may result in abbreviated data transfer possibilities. Interdisciplinary tumor board meetings, during which specialists discuss individual breast cancer cases, may benefit from increased interconnectivity of the different systems.
To improve this situation, VPH-PRISM partners are developing software for X-ray, MRI images, ultrasound, and histology from biopsies, to provide a unified display to spatially superimpose, measure, and manipulate these images. Especially helpful would be the ability to characterize the area surrounding a tumor more accurately. The project will aim to answer the questions: has this tissue changed to such a degree that it must be removed with the tumor during the operation, or can a more local excision, exposing the patient to a less invasive operation, be performed without the risk of recurrence?
To accomplish this, tissue sample pathology slides must be digitized. However, digitization generates large amounts of data, which pathologists can only partially inspect. To solve this, VPH-PRISM experts are also developing software that automatically preselects and preprocesses the data, thereby facilitating the work of the pathologist. If the venture is successful, experts estimate that digital pathology will promote a breakthrough in breast cancer care similar to the effect that the widespread introduction of mammography had on early detection that has occurred over the last 15 years.
The project will explore how a deep understanding of tissue microstructure, gleaned from histology, can aid interpretation of X-ray, MRI, and ultrasound images. Additionally challenging is the presentation of tissue sample images alongside MRI and X-ray images. Experts using computationally intensive algorithms must guarantee that multiple data sets fit perfectly together. Only in this manner can tissue parameters gathered using different scalings be spatially correlated and hence superimposed.
The goal is a software tool that supports clinicians when choosing therapy. Patient data should be grouped automatically according to shared criteria. This allows the software to provide clues for optimal chemotherapy, for instance, if a patient with particular tissue characteristics has been assigned to a particular group. This could prove useful for monitoring the progress of therapy more accurately: Is the tumor degenerating as quickly as expected when a patient undergoes a certain type of chemotherapy? If not, then the doctor could cease ineffective therapy in a timely fashion and provide the patient with alternative drugs.
VPH-PRISM stands for “Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy Through Integrated Tissue Micro-Structure Modeling.” The project is financed by the EU with a sum of 3.7 million euro, beginning in March 2013 and ending in February 2016. The consortium is composed of nine partners from five countries, including research institutes, clinical breast centers, and Philips Research.
• EIBIR, European Institute for Biomedical Imaging Research, Vienna, Austria (project coordinator)
• Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany (scientific coordinator)
• Radboud University Nijmegen Medical Center, The Netherlands
• University College London, UK
• University of Dundee, UK
• University of Chicago, USA
• Medical University of Vienna, Austria
• Boca Raton Regional Hospital, USA
• Philips Research, Hamburg, Germany
Fraunhofer MEVIS develops interactive assistance systems for clinical routines. This development focuses on medical image data used in early detection, diagnosis, therapy planning, therapy support, or follow-up.
Institute for Medical Image Computing
Tel.:+49 421 218 59231
Fax: +49 421 218 98 59231
This release was published on openPR.
Permanent link to this press release:
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.
You can edit or delete your press release Customized Therapy for Breast Cancer Patients here
News-ID: 262704 • Views: 1008
More Releases from Fraunhofer MEVIS
Intelligent Software for Patient-Friendly Radiation Therapy - The SPARTA Researc …
X-rays can provide much more than radiography for diagnosing bone fractures or internal disease. In the form of high-energy photon beams, cancer can be treated by exposing tumors to a strong dose of targeted radiation. This type of radiation therapy is currently one of the most important treatment methods for cancer; about half of all tumor patients are now treated with photon or particle beams. The novel, interdisciplinary SPARTA project
More Releases for MRI
Magnetic Resonance Imaging (MRI) Systems Market by Field Strength (High-Field MR …
Global Magnetic Resonance Imaging (MRI) Systems Market was valued at USD 5.63 Billion in the year 2017. Global Magnetic Resonance Imaging (MRI) Systems Market is further estimated to grow at a CAGR of 4.02% from 2018 to reach USD 7.13 Billion by the year 2023. The North America region holds the highest market share in 2018 and the Asia Pacific is considered as the fastest growing market in the forecasted
Mri Systems Market Trends and Segments 2020
Magnetic resonance imaging (MRI) is an integrated healthcare system which is used for imaging internal parts of body. It is most widely used for diagnostics imaging of central nervous system for detecting stroke affected areas of brain, brain tumours, imaging blood vessels and spine lesions. It involves the use of magnetism, radio waves, and a computer to produce images of body structures. MRI scans are also used widely for cardiac
North America Hybrid MRI Market: Drivers & Restraints
According to the report Hybrid MRI Market, published by Market Data Forecast, the North America market is projected to grow substantially during the forecast period. MRI is an imaging technique which involves radio frequencies and magnetic field used to picture internal structures of the body without using radiation. MRI can be merged with other powerful methods to take clearer pictures of organs or in even treating some cancers. MRI in
Development Trends in Intraoperative MRI Market 2016
Qyresearchreports include new market research report Global Intraoperative MRI Market Research Report 2016 to its huge collection of research reports. The thorough report here assembles different perspectives having a place with the general Intraoperative MRI market which verbalizes the present-day data and future exposures with reference to the dynamic powers at play. The prime reason for the examination report is to offer the endorser with an extensive format and make accessible
Global MRI Industry 2022 Trends and Review
ReportsWeb.com has announced the addition of the “Global MRI Market Research Report 2017” The report focuses on global major leading players with information such as company profiles, product picture and specification. Geographically, this report is segmented into several key Regions, with production, consumption, revenue (million USD) , market share and growth rate of MRI in these regions, from 2012 to 2022 (forecast) , covering North America, Europe, China, Japan, Southeast Asia
United States MRI System Market Report 2017
In this report, the United States MRI System market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. Geographically, this report splits the United States market into seven regions: The West Southwest The Middle Atlantic New England The South The Midwest with sales (volume), revenue (value), market share and growth rate of MRI System in these