Clinical Trials Advances And Challenges in Bispecific and Trispecific Antibodies Market

In recent years, healthcare sector has witnessed emergence of several promising multispecific antibodies which have revolutioned the management of several chronic disorders, including cancer. Multispecific antibodies consist of large family of molecules which recognizes trwo or more different antigens or epitopes. The robust idea of multispecific antibodies has led to the development of several bispecific and trispecific antibodies for the treatment of cancer and other diseases. Till date, three bispecific antibodies have entered the market whereas trispecific antibodies are mainly confined to clinical development, and are execetd to enter the market during the forthcoming years.

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The advent of these novel drugs is considered as promising systemic cancer treatment in comparison to conventional therapies, by playing vital role in enhancing therapeutic efficacy, especially against refractory cancer types. The introduction of these drugs in the market have shown high penetration in the global therapeutics market which is mainly attributed to their enhanced efficiency, specificity, and targetability towards the diseases. The robust sales of these drugs in short span of time have encouraged further research and development in this sector. At present, the pipeline of novel bispecific and trispecific antibodies is highly crowded and consists of several potential drugs which are expected to enter the market during the forecast period.

Although the low molecular weight of these agents help in better penetration in the cell, but it also contributes to a high renal clearance rate in comparison to natural antibodies. To overcome this, researchers are currently developing half life extended bispecific antibodies. Apart from this, advancement in protein engineering has also led to development of novel tandem diabodies construct, which are tetravalent bispecific antibodies provide two binding sites for each antigen to maintain the avidity of a natural bivalent antibody. These have high molecular weight, thus offering a longer half-life compared to smaller antibody constructs.

Apart from this, the production of bispecific and trispecific antibodies also varies from the production of monoclonal ntibodies, and is generally more complex owing to their high specificity. Continous research is being done to identify best expression system for multispecific antibodies because of differences in size, amino acid sequence, and conformation of the recombinant protein make it difficult to conclude a universal expression system that optimizes the yield and quality of the protein, which can be affected by many factors such as solubility and stability. However, some studies have recently shown that bispecific and trispecific can be efficiently express in bacterial and mammalian systems.

Advancement in protein production technologies in the field of antibody therapeutics will further boost the development of novel bispecific and trispecific antibody constructs. With three bispecific in the market and the increasing bispecific and trispecifics entering the clinical trials, it is suggested that the coming years will see rrapid approvals of these drugsin the management of several diseases including cancer, auto-immune, HIV, CNS, and others. In addition, identification of novel neoantigens will also drive the research and development in this field, thus propelling the growth of market.

The global bispecific and trispecific market is expected to witness high growth rates in the global market due to increase in incidences of cancer and the unmet need of targeted therapy. As per region, it is expected that US will dominate the global market owing to presence of large pharmaceutical sector, increase prevalence of cancer and increasing awareness among population for the adoption of novel targeted therapies. In addition to this, Europe occupies the second position in market owing to quick reimbursement policies; increasing rates of cancer and rise in alertness among the people escalate the region’s market growth over the analysis period.

Contact:
Neeraj Chawla
Research Head
neeraj@kuickresearch.com
+91-9810410366

Delhi,
India

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