3D Printed Artificial Corneas to Come up as Significant Future Trend in Artificial Cornea and Corneal Implant Market

The artificial cornea and corneal implant market to reach US$ 696.18 million by 2028 from US$ 421.86 million in 2021; it is expected to grow at a CAGR of 7.4% during 2021–2028.

An artificial cornea implantation surgery is performed to remove all or a part of the damaged cornea, followed by replacing it with healthy donor tissue. Currently, there is a shortage of cornea donors worldwide, and eye and tissue banking processes are in initial stages in many countries. Meanwhile, there is always a possibility that the human eye would reject the transplant, which can cause an infection to eye or the lack of vision. Cornea Implant is usually performed to treat conditions such as keratoconus and certain degenerative diseases. The artificial cornea tissue is made from polymer plastic such as silica material. Artificial cornea implant is of two types synthetic cornea implant and biosynthetic cornea implant.

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AJL OPHTHALMIC S.; ADVANCING SIGHT NETWORK; Aurolab; CORNEA BIOSCIENCES INC.; LinkoCare Life Sciences AB; KERAMED, INC.; EyeYon Medical; Florida Lions Eye Bank; Corneat Vision; and CorneaGen are among the leading companies in the artificial cornea and corneal implant market.

Impact of COVID-19 Pandemic on Artificial Cornea and Corneal Implant Market:

The COVID-19 pandemic is adversely affecting industries worldwide. The outbreak led to significant disruptions in primary industries, such as manufacturing, healthcare, energy & power, electronics & semiconductor, aerospace & defense, and construction in 2020. In response to the need to control the spread of the COVID-19 infection among people, hospitals discontinued several services and redirected their operations toward the management of the disease. Moreover, hospitals and healthcare providers has to reassign their specialist doctors to various tasks in ICUs and other COVID-19-related wards. Care receivers also avoided visits to clinics for non-lethal conditions in the first and second quarters of 2020. According to an article in Ophthalmology Times, the number of elective procedures decreased from 200 to only 10 per week in 2020. These conditions resulted in the slow growth of the artificial cornea and corneal implant market.

Based on type, the artificial cornea and corneal implant market is segmented into human cornea and artificial cornea. The human cornea segment is expected to held a larger share of the market in 2021. However, the artificial cornea segment is anticipated to register the highest CAGR in the market during the forecast period. An artificial cornea is a preferred option among patients that are likely to have less tolerance for the corneal implant received from human donors. Continuous advancements in the design of artificial corneal transplant and availability of superior postoperative care have resulted in improved outcomes.

3D printed artificial corneas made from stem cells and acellular corneal stroma have a potential to replace donated cornea in eye surgery. A team of researchers from the Pohang University of Science and Technology, and the Kyungpook National University School of Medicine in South Korea collaborated to 3D print artificial corneas using tissue-based bio-inks; the research has been published in "Biofabrication." Since the 3D printed corneas are made from corneal tissue materials, they are biocompatible, and the corneal microenvironment is reproduced through 3D cell printing technology to make them transparent, like human cornea. The 3D printed artificial corneas also help overcome the complications related to synthetic cornea implanted in patients with cataracts and other ocular complications.

Researchers at Newcastle University have also developed a 3D printed artificial cornea for the first time. After examining the eyes of a volunteer, they collected enough data to create a 3D model of the cornea. organization engineer explained that one of the most difficult aspects of this projects is using the right materials to maintain the concave shape and finding ink that that is thin enough to spray through the nozzles of the 3D printer. With just one healthy human cornea, they can 3D print 50 artificial corneas, which is a breakthrough in ophthalmology. Furthermore, one of the key advantages of 3D printing is that collagen can be deposited in layers, which allows for the simulation of the composition of collagen fibers in the natural corneal matrix. Thus, upon their successful commercialization for clinical usage, the 3D printed biocorneas are likely to emerge as a significant trend in the artificial cornea and corneal implant market.

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