Polymerase Chain Reaction Market Overview, Segmentation, Key Marketing Trends, Forecast To 2030 | Leading Players: F. Hoffman-La Roche Ltd. (Switzerland), Biorad Laboratories, Inc. (US)

Polymerase Chain Reaction (PCR) is a tool used in medical and biological research labs to make millions of copies from small amount of DNA. PCR is used for detecting the pathogens in the body during infection whether they are present or not. As PCR device can be utilised to detect various diseases such as AIDS, Lyme diseases, tuberculosis, etc. Its advantage of giving results in less time is another factor why its demand can be lucrative in the near future.

PCR test is reliable and most accurate for covid-19 and is being used presently to detect infection in human body. Rising covid-19 cases is the major factor for growth in the sales of PCR kits.

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Digital PCR taking up the Growth

Digital PCR has quite unique advantages as compared to the traditional PCR. Digital PCRs are more accurate and offer improved detection of low copy number variants. Digital PCRs are reliable technology for quantification of a selected and limited number of targets. It provides highly accurate results to sensitive and reproducible nucleic acid detection and quantification. In digital PCRs, the samples are divided into partitions in a way that there is either zero or any one target molecule available in any individual reaction. Use of nanofluidic chip in digital PCRs provide a convenient and straight forward mechanism which helps in running thousands of PCR reactions in parallel and the single sample is separated into large number of partitions and the reaction or test is carried out in each sample separately which helps in giving more accurate results. Therefore, sales of digital PCR are anticipated to remain high during the forecast period.

Requirement of PCR in Covid-19 Testing Paving the way for Growth

As covid-19 test results should come as soon as possible for the required treatment has to give on time, the PCR kits are beneficial for them. As PCR kits can deliver results and reliable diagnosis in approx. 3 hours as compared to the other laboratory tests that can take up to 6 hours. With the entire process happening in the closed tube, the chances of errors and contamination are negligible which is the need of covid-19 and other chronic diseases too. Therefore, RT-PCR has become the standard test for covid-19 pandemic. First the sample is collected through swab test and after the extraction process in the laboratory, PCR step uses special chemicals and a PCR machine (called as thermal cycler), through which millions of copies are made of the SARS-COV-2 virus’s genetic material. When one of the chemical produces a fluorescent light, the result is detected as positive. As covid-19 is highly communicable, RT-PCR kits are increasingly in demand.

High Cost of Digital PCR Kits

Although PCR kits are very important and required presently, high cost of digital PCR kits may burden the developing or under developed economies in a harsh way. Digital PCR kits are much costlier as compared to real time PCR kits. The price of digital PCRs can range from USD 55,000-1,20,000. Other factors such as growing home brew tests and rise in concerns regarding the accuracy of the PCR kits may doubt its growth in future years. There have been many cases regarding false negative reports of covid-19.

Competitive Landscape

Key players in the PCR market are Thermo Fisher Scientific, Inc. (US), F. Hoffman-La Roche Ltd. (Switzerland), BioRad Laboratories, Inc. (US), Qiagen N.V. (Germany), Agilent Technologies, Inc. (Japan), Danaher Corporation (US), Becton Dickinson and Company(US), Analytik Jena AG (Germany), Promega Corporation US), BioMeriux S.A. (France), Takara Bio, Inc. (Japan), Merck KGaA (Germany), Promega Corporation (US), Mobidiag, Eppendorf AG (Germany), etc.

Atik Cameras, designer and manufacturer of advanced scientific imaging solutions have collaborated with Original Equipment Manufacturers (OEM’S) of real time PCR DNA amplifiers in February 2021 to supply cameras for reliable covid-19 testing. OEM’s will access Atik Cameras and customised charge coupled devices (CCD) and complimentary metal oxide semiconductor (CMOS) cameras that can be used with PCR instruments. Advanced CMOS Imaging Systems are well recognised as a camera which is ideal for meeting the imaging needs of PCR applications.

Mobidiag, a Finnish-French developer of innovative molecular diagnostic tests and instrumentation has made an agreement with Hologic, a women;s health specialist recently in April this year. Mobidiag develops and markets PCR based tests for accurate care conditions for respiratory infections, gastrointestinal, antimicrobial resistance management, etc. With Hologic, the company is aiming to drive more customer base in Europe, Finland, France, Sweden, UK, etc. With the commercial expertise and investment strength of Hologic, the company aims to accelerate the broader market adoption of their products. Also, Mobidiag is aiming to target US market with the help of Hologic’s established US market

In 2020 Roche acquired Stratos Genomics to further develop DNA based sequencing for diagnostic use and to advance the development of Roche’s nanopore sequencer. The acquisition is made to provide Roche access to Stratos Genomics unique chemistry, sequencing by expansion. The nanopore sequencer combines electronic and biological components to sequence DNA for fast and cost-effective diagnostic testing.

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Regional Outlook

The growth of Polymerase Chain Reaction is anticipated to drive due to the spread of covid-19 all over the world. Although, some countries are witnessing less cases as compared to 2020, there are still some countries where infection rates are rising higher and need for PCR kits is very important there. Other major factors invovong the growth of PCR technologies include rising geriatric population, prevalence of other high infectious diseases, increasing established medical infrastructure and technologically advanced hospitals.

Covid-19 have caused the rise in requirement of PCR kits. In US, there are 32,149,223 covid-19 cases as of 15th April 2021 and thousands of people waiting for tests to be done. Therefore, covid-19 is presently the major cause of demand of RT-PCR kits in the market. Large number of companies in US, manufacturing PCR kits are helping the hospitals in rapid testing. For instance, InBios smart detect r RT-PCR kits, Gnomegen RT-Digital PCR Detection Kit, Co-Diagnostic Inc., Logix Smart covid-19 kit, etc. are approved by FDA for cvid-19 testing. Growing incidences of other chronic diseases also give rise to the demand of PCR kits in hospitals.

Requirement of PCR kits in Europe also have been in high demand. According to European Centre for Disease Prevention and Control, in first week of April, there were 27,513,674 reported cases in European Union in which France (4,822,470), Italy (3,668,264), Spain (3,311,325), Germany (2,893,883), Poland (2,448,463), Netherlands (1,305,803), are in top positions. People with mild cough, flu are getting covid tested due to fear and therefore, increasing the utilisation of PCR kits. The companies have been launching affordable RT PCR kits. For instance, GeneStore in June 2020 launched “Made in France” test which can deliver results in 1 hour based on RT-PCR approach only at the minimal amount of 9.9 Euros.

Asia Pacific is also growing in demand for RT-PCR kits. India, in May 2020, placed order for 6.3 million RT-PCR kits to test covid-19 infection among people. Recently in February 2021, Thermo Fisher started its new facility to develop RT-PCR kits in Bengaluru, India. They are claiming to manufacture upto 10 million tests every month. The kit is approved by Indian Council of Medical Research and Drug Control General of India. Therefore, as per the demand, the manufacturing is increasing. Singapore have also been developing its Quiz PCR Biochips for testing covid-19 patients. Cell ID Pte. Ltd. in Singapore have developed a palm sized portable genetic test kit which uses laptop or an app to detect covid-19 infection anywhere, any time. Thus, helping in less burden on hospitals.

Segmentation

Based on Technique

Real-time PCR
Digital PCR
Hot-start PCR
Multiplex PCR
Reverse Transcription PCR
Based on product

Instruments
Reagents and consumables
Software and services
Based on Application

Gene analysis
Genotyping
Nucleic acid detection
Standard validation
Diagnostic Applications
Environmental Applications
Genetic sequencing
Based on End User

Hospitals and diagnostic labs
Healthcare Industry
Academia and government organisations
Applied Industries
Pharmaceutics
Based on Region

North America
Europe
Asia Pacific
Latin America
Middle East and Africa
Key Questions Answered​

Who are the leading players in the market?F. Hoffman-La Roche Ltd. (Switzerland), BioRad Laboratories, Inc. (US), Qiagen N.V. (Germany), Agilent Technologies, Inc. (Japan), Danaher Corporation (US), Becton Dickinson and Company(US), etc.
What are the key marketing trends for the growth of PCR kits?Covid-19 pandemic is the leading cause of demand for PCR kits.
What are the end user facilities requiring PCR kits the most?Hospitals, Clinics, etc.
Which countries are expected to surge the demand of PCR kits?US, France, Italy, India, etc.
Which type of PCR is projected to grow during the forecast period?Digital PCR kits.

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