Alpha-Antitrypsin Deficiency (AATD) Market Stunning Revenues by 2028| Grifols, Kamada, Shire, CSL Behring, LFB Biotechnologies, Alnylam Pharmaceuticals, Arrow Head Pharmaceuticals, Vertex, Mereo Biopharma

Alpha-1 antitrypsin deficiency (AATD) is an inherited disease that causes an increased risk of having chronic obstructive pulmonary disease (COPD), liver disease, skin problems (panniculitis), and inflammation of the blood vessels (vasculitis).

Alpha-1 antitrypsin deficiency occurs worldwide, but its prevalence varies by population. This disorder affects about 1 in 1,500 to 3,500 individuals with European ancestry. It is uncommon in people of Asian descent.

It is an autosomal recessive disorder. The most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure.

There is no cure, but treatment can help people with AAT deficiency manage their symptoms and live a better life. It is estimated that there are between 80,000 to 100,000 individuals affected by AAT deficiency in the United States.

Alpha-1 antitrypsin deficiency is an hereditary form of emphysema, which accounts for 2-3% of all instances of emphysema and which is worsened by other risk factors for COPD (like cigarette smoking).

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Key Players-
• Grifols
• Kamada
• Shire
• CSL Behring
• LFB Biotechnologies
• Alnylam Pharmaceuticals
• Arrow Head Pharmaceuticals
• Vertex Pharmaceuticals
• Mereo Biopharma
• Dicerna Pharmaceuticals
• Inhibrx
• Vertex Pharmaceuticals

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Market segmentation:
By Symptoms
• Tiredness
• loss of appetite
• weight loss
• swelling of the feet or belly
• yellowish discoloration of the skin (jaundice)
• white part of the eyes
• vomiting of blood
• blood in stools
By End use
• Hospitals
• Clinics
• Surgical Centers

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