Recombinant Protein Market continues to expand with Biosimilars Applications

Recombinant proteins have immense potential in cancer therapy research and development. For instance, growth factors, immune checkpoint, and cell damage & oxidative stress proteins (preclinical stage) are utilized from recombinant proteins category for cancer therapy research. Increased understanding of oncogenic signaling pathways and proteins involved in the same has increased the targeting ways, wherein, recombinant proteins such as immune checkpoint, growth factors, and antibodies are used. These proteins are used extensively by researchers to research cancer signaling pathways and functioning.

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Recombinant immune checkpoint such as PD-1/PD-L1 Inhibitor 1 and PD-1/PD-L1 Inhibitor 2, which directly targets programmed death-1 (PD-1) and programmed death ligand-1 and 2 (PD-L1) are used for research purposes. Moreover, proteins such as CD226, CD40 Ligand/TRAP, and Human CellExp CTLA4/CD152 are extensively used in cancer therapies research.

Availability of wide number of innovative recombinant proteins from various sources such as human and animal, lack of suitable alternative for basic protein related therapies research, and increasing demand for biopharmaceutical products is expected to fuel growth of the recombinant protein market.

Manufacturers are involved in collaborations and acquisitions for drug discovery and development purposes. For instance, in 2017, Crown Bioscience (CBI), Inc. entered into collaboration with Jiangsu Qyun Bio-Pharmaceutical Co. Ltd. to develop CTLA-4 antibody. Moreover, in 2016, CBI acquired PreClinOmics, Inc., an in Vivo preclinical company, which specializes in early research in cardiovascular and metabolic disease and in 2016 CBI introduced six new recombinant cell lines GITR, ICOS, CD137, CTLA-4, OX40, and RANK immune checkpoints and receptors for biological studies, drug discovery, and development.

In 2012, ProSpec-Tany Technogene Ltd. and LifeMap Sciences, Inc.—a wholly owned subsidiary of BioTime, Inc.—announced definitive agreement to offer 1,000 recombinant proteins and antibodies, to be used for stem cell research, drug discovery, and development biology. In 2014, BPS Bioscience, Inc. announced the introduction of 13 different mutant EZH2 complexes and two new assay kits for screening inhibitors of mutant EZH2.

Major Market Competitors: Crown Bioscience, Inc., ProSpec Tany TechnoGene, Ltd., BPS Bioscience, Inc., Sigma Aldrich Company Ltd., Novoprotein Scientific, PeproTech, Inc., Feldan Bio, Inc., BioVision, Inc., HumanZyme, Inc., and GenScript Biotech Corporation.

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