Bone Grafts and Substitutes Market Expected to Reach 3.36 Billion by 2028 | Medtronic Plc., NuVasive Inc., Stryker Corporation

According to the report, The global bone grafts and substitutes market was valued at $2,652.6 million in 2020, and is projected to reach $3,362.6 million by 2028, registering a CAGR of 4.3% from 2021 to 2028.

North America held the dominant position in the global market in 2017, and is expected to maintain its lead throughout the analysis period. This is attributed to rise in incidence of spinal fusion & joint reconstruction procedures, sedentary lifestyle contributing to joint disorders in the geriatric & younger population, and favorable reimbursement rates in the region.

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Rapid development of novel bone grafts materials such as biocompatible synthetic bone grafts and rise in prevalence of bone and joint disorders are the major factors driving the growth of the global bone grafts and substitutes market. Moreover, surge in the number of patients suffering from rheumatoid arthritis, osteoarthritis, and other joint disorders have supplemented the market growth.

However, high cost of surgeries and several ethical issues associated with bone grafting procedures have hampered the market development. On the contrary, increasing inclination of key market players toward R&D activities and surge in demand for orthopedic procedures among geriatric population would provide lucrative opportunities for the market leaders in the coming years.

Increase in incidence of musculoskeletal conditions, advancements in medical technology leading to a shift from autograft to allograft, rise in preference for biocompatible bone grafts are the key factors that contribute toward the growth of the global bone grafts and substitutes market.


In addition, increase in cases of lifestyle disorders such as diabetes and obesity add to the risk of developing degenerative joint diseases that further fuels the growth of the market. However, the major restraints of this market are ethical issues related to bone grafting and high cost of surgeries.

Major applications of bone grafts and substitutes

The report offers an in-depth analysis of the various applications of bone grafts and substitutes, including spinal fusion, trauma, joint reconstruction, dental bone grafting, and craniomaxillofacial. The spinal fusion segment dominated the global bone grafts and substitutes market in 2017 and is expected to hold the largest share in the global market through 2025, contributing about 45%.

However, the joint reconstruction segment would witness the fastest CAGR of 6.2% through 2025, owing to rise in demand for joint reconstruction among patients suffering from rheumatoid arthritis, osteoarthritis, and other joint disorders.

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Key market players

The leading companies in the global bone grafts and substitutes market include Medtronic plc, DePuySynthes, Wright Medical Group N.V., Xtant Medical Holdings, Inc. (Bacterin), Baxter International Inc., Stryker Corporation, Integra Lifesciences Holdings Corporation, Zimmer Biomet Holdings, Inc., Arthrex, Inc., and Musculoskeletal Transplant Foundation (MTF).

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