Cell Line Development Market 2021: Business Growth | Top Players are Lonza Group AG, Sigma-Aldrich Corporation, Wuxi App Tec

Cell line is a permanently established cell culture, which proliferates indefinitely if it is given appropriate fresh medium and space. Cell line is typically used to examine effectiveness of drug discovery and toxicity. Cell lines are crucial in the production of recombinant proteins production such as, monoclonal antibodies, bi-specific monoclonal antibodies, growth factors, and enzymes using a wide variety of expression systems. Cell lines saves the crucial time, effort and cost by providing the high yield cells, which can be used for in vitro testing and reduce chance of research drug to fail in clinical trial stage.

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Market Dynamics- Drivers

Development of novel therapy to drive growth of the global cell line development market
Cell line development finds applications in various sectors including treatment of cancer. According to the World Health Organization (WHO) factsheet 2012, cancer is one of the leading cause of death from top three causes of non-communicable disease.

Pharmaceutical and biotechnological companies are involved in development of novel therapies such as immunotherapy, owing to its specificity and efficiency. Cell line development is extremely useful in speeding drug discovery process and optimization of clinical trials by providing high yield of monoclonal antibodies, which is expected to drive growth of the global cell line development market during the forecast period.

Global Cell Line Development Market Taxonomy

On the basis of Product type:
• Reagents & Media
• Equipment
On the basis of source:
• Mammalian
• Non-Mammalian
On the basis of cell line:
• Recombinant
• Hybridomas
• Continuous Cell Line
• Primary Cell Line
On the basis of application:
• Bioproduction
• Drug Discovery
• Toxicity Testing
• Tissue Engineering
• Research
On the basis of end user:
• Pharmaceutical companies
• Research and Academic Institution

Competitive Landscape

Collaborations by cell line development companies with drug discovery companies to speed up expansion of the global cell line development market

Key companies operating in the global cell line development market include Lonza Group AG, Sigma-Aldrich Corporation, Wuxi App Tec, Inc., American Type Culture Collection, Thermo Fisher Scientific, Inc., PX’Therapeutics SA., Selexis SA, GE Healthcare, European Collection of Cell Cultures, Corning, Inc., Sartorious AG, Goodwin Biotechnology Inc., and Cleancells.

• In December 2017, Selexis SA entered into third commercial license agreement with Turgut Pharmaceuticals, which would provide Turgut with access to Selexis SUREtechnology Platform and SURE CHO-M Cell Line for the development of biosimilar product for the treatment of two rare diseases such as paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. The companies were already in agreement (made in July 2016) to develop biosimilar products to treat inflammatory diseases and certain cancers using the SURE CHO-M Cell Lines.

• In October 2017, Selexis SA entered into an agreement with Pelican Therapeutics (subsidiary of Heat Biologics, Inc.) for the development of Pelican’s immunotherapy clinical candidates PTX-35 and PTX-15. Pelican would utilize Selexis’s SUREtechnology PlatformTM to rapidly develop high-performance research cell banks expressing two of research candidate such as PTX-35, which is humanized monoclonal antibody that is a functional agonist of human TNFRSF25, and PTX-15, which is a human TL1A-Ig fusion protein.

• In November 2017, American Type Culture Collection introduced an innovative in vitro model system of cell lines for key mechanism of invasion and metastasis in lung cancer

• In January 2018, PX’Therapeutics collaborated with biotech firm Advaxis for process development of immunotherapies of Advaxis

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