openPR Logo
Press release

Hunter Syndrome Pipeline Insight Market Research Report 2020 | Shire, Regenxbio, Takeda, Denali Therapeutics, Centogene AG Rostock, JCR Pharmaceuticals Outlook, Therapy, Emerging Drugs, Therapeutic Assessment, Phases, Pipeline Development Analysis

09-20-2020 09:15 AM CET | Health & Medicine

Press release from: Mart Research

/ PR Agency: Mart Research
Hunter Syndrome Pipeline Insight Market Research Report

Hunter Syndrome Pipeline Insight Market Research Report

Hunter Syndrome Pipeline Insight, 2020, report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Hunter Syndrome pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
- Global coverage

Hunter Syndrome Understanding
Hunter Syndrome: Overview
Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a condition that affects many different parts of the body and occurs almost exclusively in males. It is a progressively debilitating disorder; however, the rate of progression varies among affected individuals. There are two types of MPS II, called the severe and mild types. While both types affect many different organs and tissues as described above, people with severe MPS II also experience a decline in intellectual function and a more rapid disease progression.

Symptoms
In the neuronopathic form of this disorder, physical and mental development reaches a peak at 2-4 years of age with subsequent deterioration. Recurrent upper respiratory infections, a chronic runny nose, hearing impairment, liver and spleen enlargement, inguinal and abdominal hernias, joint stiffness and multiplex dysplasia, compression of tendons in the wrist (carpal tunnel syndrome), and joint stiffness which can result in reduction of hand function, growth failure and valvular disease commonly occur with this form of MPS II. Manifestations of MPS II may include not inflammatory joint stiffness, with associated restriction of movements; and coarsening of facial features, including thickening of the lips, tongue (macroglossia), and nostrils.

Diagnosis
The signs and symptoms of MPS II vary greatly, so the diagnosis cannot be made by physical exam alone. Diagnosis requires documentation of reduced or absent iduronate 2-sulfatase enzyme activity in blood or skin cells. A very simple determination of glycosaminoglycans in the urine may help in screening potential positive patients. Patients with MPSII disease accumulate heparin and dermatan sulfates in the urines. Molecular genetic testing for mutations in the IDS gene is available to confirm the diagnosis. It is always important to rule out a multiple sulfatase deficiency by testing other sulfatase enzymes.

Request a Sample of Hunter Syndrome Pipeline Insight Market Research Report @ https://martresearch.com/contact/request-sample/2/46022

Treatment
- An enzyme replacement therapy, idursulfase (Elaprase), was approved in 2006 by the U.S. Food and Drug Administration (FDA) as a treatment for MPS II. This drug is sponsored by Shire.
- Other treatments of MPS II are symptomatic and supportive. These management interventions commonly include developmental, occupational and physical therapy. Hernias and joint contractures may be corrected by surgery.
- Tonsillectomy and adenoidectomy (surgical removal of both the tonsils and the adenoids) can be used to alleviate breathing and swallowing problems. Positive pressure ventilation (CPAP or tracheostomy) can be used to apply mild air pressure to keep the airway open to alleviate breathing issues. Carpal tunnel release can treat carpal tunnel syndrome.
- Surgical implantation of a ventricular shunt may be used to treat possible hydrocephalus. Hearing devices may be prescribed to treat hearing loss. Developmental, physical, and occupational therapy can be helpful.

Hunter Syndrome Emerging Drugs Chapters
This segment of the Hunter Syndrome report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Hunter Syndrome Emerging Drugs
- DNL310: Denali Therapeutics Inc.
DNL310, or ETV:IDS, is a recombinant form of the iduronate 2-sulfatase (IDS) enzyme engineered to cross the blood-brain barrier using Denali’s proprietary ETV technology. DNL310 is intravenously administered and intended to improve overall clinical manifestations of Hunter Syndrome, including neurological symptoms, which are not adequately addressed by currently approved therapies.
The TV technology enables improved uptake and distribution of therapeutic antibodies, enzymes and other proteins in the brain after i.v. administration by binding to natural transport receptors in the vasculature of the brain. Pre-clinical studies with the TV technology have shown up to 30-fold increased uptake and superior pharmacological activity compared to standard antibodies, enzymes and other proteins. Denali is developing a broad portfolio of biologic drug candidates that are enabled by its TV technology. Based on pre-clinical proof of concept with DNL310, Denali initiated two additional ERT programs that are enabled by the TV technology.
Further product details are provided in the report....

Browse the Full Hunter Syndrome Pipeline Insight Market Research Report @ https://martresearch.com/market-analysis/hunter-syndrome-pipeline-insight-2020/2/46022

Hunter Syndrome: Therapeutic Assessment
This segment of the report provides insights about the different Hunter Syndrome drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Hunter Syndrome
There are approx. 10+ key companies which are developing the therapies for Hunter Syndrome. The companies which have their Hunter Syndrome drug candidates in the mid to advanced stage, i.e. phase III and Phase I/II include, JCR Pharmaceuticals, Shire, Denali Therapeutics Inc., Regenxbio Inc. etc.

Phases
This report covers around 10+ products under different phases of clinical development like
- Mid-stage products (Phase II and Phase I/II)
- Early-stage products (Phase I/II and Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates

- Route of Administration
Hunter Syndrome pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
- Subcutaneous
- Intravenous
- Intramuscular
- Molecule Type

Products have been categorized under various Molecule types such as
- Recombinant fusion proteins
- Gene therapies
- Enzymes

Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Hunter Syndrome: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Hunter Syndrome therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Hunter Syndrome drugs.

Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Hunter Syndrome R&D. The therapies under development are focused on novel approaches to treat/improve Hunter Syndrome.
- May 2020: Denali therapeutics announces publication of two new papers describing its blood-brain barrier delivery technology in science translational medicine.
- The first Denali-authored paper published in STM today, by Kariolis et al. entitled Brain delivery of therapeutic proteins using a novel Fc fragment blood-brain barrier transport vehicle in mice and monkeys, describes the development and engineering of the TV platform, and demonstrates how it increases brain exposure and distribution of certain antibodies in preclinical models including non-human primates.

Hunter Syndrome Report Insights
- Hunter Syndrome Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs

Hunter Syndrome Report Assessment
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs

Key Questions
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Hunter Syndrome drugs?
- How many Hunter Syndrome drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of
Hunter Syndrome?
- What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Hunter Syndrome therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Hunter Syndrome and their status?
- What are the key designations that have been granted to the emerging drugs?

Key Players
- Denali Therapeutics Inc.
- Shire
- Regenxbio Inc.
- Green Cross Corporation
- Takeda
- Centogene AG Rostock
- JCR Pharmaceuticals Co., Ltd.

Key Products
- Idursulfase-IT
- DNL310
- RGX-121
- Idursulfase-IT
- GC1111
- SB-913

Buy Full Hunter Syndrome Pipeline Insight Market Research Report @ https://martresearch.com/paymentform/2/46022/Single_User

Contact Us:
Mart Research
5708 Copper Creek Court Charlotte North Carolina 28227, USA
+1-857-300-1122
sales@martresearch.com

About Us:
We, at MART RESEARCH value your time the most as we believe that time saved is directly proportional to profits earned. Before launching ourselves into this service, we did an extensive survey to understand the challenges clients face while gaining access to authentic data reports. The need of the hour was a common platform which could showcase published reports across a wide range of sectors. To overcome this limitation, we setup a repository which is a comprehensive one-stop shop for all your report requirements. It is user friendly, easy to browse, search and acquire reports which would fulfill your generalized as well as customized business needs.

This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release Hunter Syndrome Pipeline Insight Market Research Report 2020 | Shire, Regenxbio, Takeda, Denali Therapeutics, Centogene AG Rostock, JCR Pharmaceuticals Outlook, Therapy, Emerging Drugs, Therapeutic Assessment, Phases, Pipeline Development Analysis here

News-ID: 2137707 • Views: 564

More Releases from Mart Research

Deep Brain Stimulation Devices Pipeline Insight Market Research Report 2020 | Ad …
Deep Brain Stimulation Devices - Pipeline Insight and Competitive Landscape, 2020 report provides comprehensive insights about 20+ companies and 23+ pipeline devices in deep brain stimulation (DBS) devices pipeline landscape. The DBS market is expected to undergo substantial growth in the coming years owning to an increasing prevalence of neurological disorders around the world. The growing aging population is also a major growth factor for DBS devices market as
Artificial Lung Devices Pipeline Insight Market Research Report 2020 | ALung Tec …
Artificial Lung Devices - Pipeline Insight and Competitive Landscape, 2020 report provides comprehensive insights about 20+ companies and 23+ pipeline devices in artificial lung devices pipeline landscape. Globally, number of cases related to respiratory failure and cardiopulmonary collapse has grown rapidly. This has resulted in increasing demand for artificial lung that acts as an external support system providing oxygenation of blood and removal of carbon dioxide from the blood. Researcher
Biopsy Devices Pipeline Insight Market Research Report 2020 | Outlook, Product T …
Biopsy Devices - Pipeline Insight and Competitive Landscape, 2020 report provides comprehensive insights about 20+ companies and 23+ pipeline devices in biopsy devices pipeline landscape. Significant increase in incidence of cancer, such as breast, prostate, and lung, and rapid technological advancements such as 3D optical biopsies, MRI-targeted biopsies, and Ultrasound-guided biopsies fuel the adoption of biopsy devices. Moreover, rise in awareness on diagnosis of chronic diseases fosters the demand for
Coronary Stents Pipeline Insight Market Research Report 2020 | REVA Medical, Ron …
Coronary Stents - Pipeline Insight and Competitive Landscape, 2020 report provides comprehensive insights about 20+ companies and 20+ pipeline devices in Coronary Stents pipeline landscape. Owing to the rise in the prevalence of coronary artery diseases (CAD), the coronary stents market is witnessing remarkable growth. Significant players are focusing on expanding their geographical reach, for dominating the current market. According to the Centre for Disease Control and Prevention, about one-third

All 5 Releases


More Releases for Hunter

Hunter Global Holdings Limited Investment Approach
Investment Analysis The majority of the modern investment world is built around the idea that savvy investors can utilize today's almost limitless informational resources, all-powerful analytical systems and tools together with the opinions of experts to beat the market. It seems to be a reasonable conclusion that this makes sense: By selecting the right stocks, employing the right broker, finding the right manager and predicting the right time to buy or sell,
Global Blackout Curtains Market 2018-2025 JINCHAN, Major, Hunter Douglas
A market study "Global Blackout Curtains Market" examines the performance of the Blackout Curtains market 2018. It encloses an in-depth Research of the Blackout Curtains market state and the competitive landscape globally. This report analyzes the potential of Blackout Curtains market in the present and the future prospects from various angles in detail. The Global Blackout Curtains Market 2018 report includes Blackout Curtains market Revenue, market Share, Blackout Curtains industry volume,
Padang Bai as The Main Port of Fast Boat Hunter
Padangbai is a village in Manggis, Karangasem regency, on the eastern side of Bali Island, Indonesia. The city became a ferry port for voyages to Lombok Island, Nusa Penida, Gili Islands and other islands in West Nusa Tenggara. Most visitors to Padang Bai are there to catch a boat to Lombok. Padangbai also offers the life of a beautiful and quiet little beach town in the form of a bay. Because
Hunter Introduces The Original Tour Boot
Always on the forefront of functionality and style, Hunter is proud to introduce the new Original Tour Boot to their collection, their first rain boot designed to make traveling that little bit easier. The latest addition to Hunter Boot's renowned collection of rain boots has launched and it has one, very important difference; it's been designed with traveling in mind. The Original Tour Boot is Hunter's first travel-friendly rain boot, which
J. Mendel and Hunter Boot Launch Exclusive Collaboration
The two iconic brands have joined forces in a special collaboration to produce the most elegant and glamorous of wellington boots, which will be exclusive to customers in North America. The luxury fashion brands, J.Mendel and Hunter Boot have come together to create a new wellington boots collection that will showcase the look and feel of J.Mendel's classic designs with the timeless functionality of Hunter Boot. This collaboration, which
Grazia and Hunter Boots Launch Festival Style Hunter
Hunter and Grazia are joining forces at some of this summer’s coolest festivals in a search to find the best dressed festival-goers of the season. Hunter are delighted to announce that they have teamed up with Grazia, the leading weekly fashion magazine on a quest to find the UK's best dressed festival goers. The team will be at Lovebox from 15 – 17 June, Wilderness from 10 – 12 August and