Press release
TRAIL Receptor 1 & Receptor 2 Agonist Pipeline Analysis 2020 Along with Research Report 2030
TRAIL Receptor 1 & Receptor 2 Agonist -Pipeline Insight, 2020: The report presents an in-depth assessment of TRAIL Receptor 1 & Receptor 2 Agonist including enabling technologies, key trends, market drivers, challenges, standardization, regulatory landscape, deployment models, operator case studies, opportunities, future roadmap, value chain, ecosystem player profiles and strategies. The report also presents forecasts for TRAIL Receptor 1 & Receptor 2 Agonist investments from 2020 till 2030Major Key Players:AbbVie, Apogenix, BioInvent, Amgen, Genmab, Medimmune
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Executive Summary
The maintenance of B cell homeostasis requires a tight control of B cell generation, survival, activation, and maturation. In lymphocytes upon activation, increased sensitivity to apoptotic signals helps controlling differentiation and proliferation. The death receptor Fas is important in this context because genetic Fas mutations in humans lead to an autoimmune lymphoproliferative syndrome that is similar to lymphoproliferation observed in Fas-deficient mice. In contrast, the physiological role of TNF-related apoptosis-inducing ligand receptors (TRAIL-Rs) in humans has been poorly studied so far.
The Induction of TRAIL-Rs with distinct kinetics, which differed among B cell subpopulations: switched memory cells rapidly upregulated TRAIL-R1 and -2 upon activation while naïve B cells only reached similar expression levels at later time points in culture. Increased expression of TRAIL-R1 and -2 coincided with a caspase-3-dependent sensitivity to TRAIL-induced apoptosis in activated B cells but not in freshly isolated resting B cells. Finally, both TRAIL-R1 and TRAIL-R2 could signal actively and both contributed to TRAIL-induced apoptosis. In conclusion, this study provides a systematic analysis of the expression of TRAIL-Rs in human primary B cells and of their capacity to signal and induce apoptosis. This dataset forms a basis to further study and understand the dysregulation of TRAIL-Rs and TRAIL expression observed in autoimmune diseases. Additionally, it will be important to foresee potential bystander immunomodulation when TRAIL-R agonists are used in cancer treatment.
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Influence of TRAIL Receptor 1 & Receptor 2 Agonist market report:
-Comprehensive assessment of all opportunities and risk in TRAIL Receptor 1 & Receptor 2 Agonist market.
-TRAIL Receptor 1 & Receptor 2 Agonist market recent innovations and major events.
-Detailed study of business strategies for growth of TRAIL Receptor 1 & Receptor 2 Agonist market-leading players.
-Conclusive study about the growth plot of TRAIL Receptor 1 & Receptor 2 Agonist market for forthcoming years.
-In-depth understanding of TRAIL Receptor 1 & Receptor 2 Agonist market-particular drivers, constraints and major micro markets.
-Favourable impression inside vital technological and market latest trends striking TRAIL Receptor 1 & Receptor 2 Agonist market.
The research includes historic data from 2015 to 2018 and forecasts until 2023 which makes the reports an invaluable resource for industry executives, marketing, sales and product managers, consultants, analysts, and other people looking for key industry data in readily accessible documents with clearly presented tables and graphs.
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MarketInsightsReports provides syndicated market research on industry verticals including Healthcare, Information, and Communication Technology (ICT), Technology and Media, Chemicals, Materials, Energy, Heavy Industry, etc. MarketInsightsReports provides global and regional market intelligence coverage, a 360-degree market view which includes statistical forecasts, competitive landscape, detailed segmentation, key trends, and strategic recommendations.
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