openPR Logo
Press release

Thermo Fisher Scientific Screening Library Advances Drug Discovery Research at Temple University’s Moulder Center

10-20-2011 12:59 PM CET | Science & Education

Press release from: Thermo Fisher Scientific Inc

/ PR Agency: Alto Marketing
20,000-molecule Maybridge collection will help identify compound candidates to treat a wide range of diseases

Thermo Fisher Scientific Inc., the world leader in serving science, today announced that the Moulder Center for Drug Discovery Research at Temple University’s School of Pharmacy has selected the company’s Maybridge screening libraries to identify compounds that might be useful in treating health problems as diverse as Alzheimer’s disease, cancer and drug dependency.

Thermo Fisher will provide the Moulder Center with a custom compound library based initially on the 14,000-strong HitFinder™ collection. This library will be used within the university as well as by its continually expanding list of academic, pharmaceutical and biotechnology partners.

The Moulder Center is led by Dr. Magid Abou-Gharbia, a highly respected scientist whose work in the drug discovery field has produced five FDA-approved therapeutics. The center conducts in-house research using its state-of-the-art laboratory facilities. These studies are currently focused on the identification of compounds targeting drug addiction and withdrawal symptoms as well as the development of Alzheimer’s disease. Each is built on a foundation of rational design that is based on “Lipinski's Rule of Five,” which utilizes both computer aided analysis and high-throughput screening assays.

With an expanded Maybridge HitFinder library of more than 20,000 candidate molecules, the team at the Moulder Center hopes to screen a wide range of compounds. “We needed a large but manageable library that was still flexible enough to meet the needs of our drug discovery programs and those of our collaborators,” said Dr. Abou-Gharbia. “We aim to expand the already excellent HitFinder library by taking advantage of the extensive range of related compounds offered by the Maybridge service. The Maybridge experts provided exceptional technical and data support, making it easy to add the new molecules to our collection database.”

In addition to conducting its own research, the Moulder Center collaborates with many research partners, using its expertise and resources to enrich and expand their drug discovery pipelines. “One of our primary aims is to provide a conduit that helps researchers move forward from their exciting early stage research and turn their discoveries into drugs to treat disease,” said Dr. Abou-Gharbia. “Plugging this gap will help to ensure that research laboratories, especially those in the academic sector, have the support they need to move efficiently and accurately through the drug discovery process.”

The Maybridge HitFinder collection is a premier offering of drug-like screening compounds that uses an industry standard clustering algorithm to select a statistically representative sample of the full collection. All compounds have purity greater than 90 percent and have been selected to be non-reactive, ensuring fewer false positives and higher-quality results.

For further information on this product please visit www.maybridge.com.

About the Moulder Center for Drug Discovery Research

The Moulder Center for Drug Discovery Research was established in Temple University’s School of Pharmacy in 2008. The Center is located in Philadelphia, Pa., a region that has historically been the home to so many of the pharmaceutical companies that it has become the heart of pharma or biomedical research, and has earned the moniker, “Silicon Valley of biomedical research and drug discovery.” Led by its director, Dr. Magid Abou-Gharbia, the Moulder Center is a fully integrated drug discovery facility, involved in multi-disciplinary research and featuring state-of-the-art medicinal chemistry and screening laboratories, a 20,000-compound library that allows for drug screening and optimization, as well as computer-aided drug design or CADD to do virtual drug screening. The Center's research capabilities are enhanced through its numerous internal and external collaborations and partnerships.

About Maybridge

Maybridge, a Thermo Fisher Scientific brand, is well known for highly innovative drug-like molecules and screening compounds for drug discovery and development. With products available for both lab and development scale, the Maybridge line features new heterocyclic and phenyl ring-based chemical building blocks, including a unique and expanding range of reactive intermediates. For more information about Maybridge brand products, visit www.maybridge.com or call +44 18 40 77 05 67.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit www.thermofisher.com.

Alto Marketing Limited
Office 3 Universal Marina | Crableck Lane | Sarisbury Green | Southampton | SO31 7AL | UK

Media Contact Information:
Name: Sarah Perceval, Alto Marketing
Tel: +44 (0)1489 557672
Email: sarahp@alto-marketing.com

Secondary Contact Information:
Tracy Cartier, Thermo Fisher Scientific
Tel: +1 978-905-1201
Email: tracy.cartier@thermofisher.com

This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release Thermo Fisher Scientific Screening Library Advances Drug Discovery Research at Temple University’s Moulder Center here

News-ID: 197136 • Views: 1352

More Releases from Thermo Fisher Scientific Inc

Thermo Fisher Scientific Introduces System to Double Cryogenic Storage Capacity
Thermo Scientific Dense Storage Format Also Reduces Storage Costs Thermo Fisher Scientific Inc., the world leader in serving science, today introduced the Thermo Scientific Dense Storage system for low-temperature storage of biological samples and solutions. The system combines 1 mL Thermo Scientific Nunc CryoBank tubes with the new 13 x 13 tube dividers and Nunc™ CryoBoxes. This novel Dense Storage format effectively doubles existing storage capacity, which can reduce costs
Thermo Fisher Scientific Expands its Sample Storage Product Portfolio
Thermo Scientific Matrix Amber 2D Barcoded Tubes Protect Light-Sensitive Samples Thermo Fisher Scientific Inc., the world leader in serving science, today introduced new Thermo Scientific Matrix Amber 2D barcoded tubes, expanding its sizeable sample storage product portfolio to offer protection of light-sensitive samples. Available in 0.5 and 1.0 mL sizes, these sterile, DNase/RNase-free tubes are composed of Virgin Class IV Medical Grade Polypropylene with added amber color to safeguard samples
Thermo Fisher Scientific Introduces New µDrop Plate for Low-Volume Measurements
Quick and Easy Tool for DNA or RNA Assays Using Small Sample Volumes Thermo Fisher Scientific Inc., the world leader in serving science, today announced the new Thermo Scientific µDrop Plate for the quick and easy measurement of samples down to 2 µL. The µDrop™ Plate provides a straightforward way of analyzing up to 16 microliter-scale samples simultaneously. The fixed light path of the plate allows direct calculation of nucleic acid
Thermo Fisher Scientific Instruments Optimize H1N1 Screening
Thermo Scientific KingFisher Flex Increases Throughput for Infectious Disease Research Thermo Fisher Scientific Inc., the world leader in serving science, today announced that it has supplied a Thermo Scientific KingFisher Flex magnetic particle processor to Labor Krone and IMOLTEC (University of Applied Sciences, Bielefeld), Germany to enable research into H1N1 screening. Using the advanced flexibility and high-speed processing capabilities of the KingFisher Flex, Dr. Carsten Tiemann, head of the department, was

All 5 Releases


More Releases for Maybridge

Thermo Fisher Scientific Expands Maybridge Ro3 Diversity Fragment Library
Maximises Effectiveness in Structure-Based Drug Discovery Thermo Fisher Scientific, the world leader in serving science, today announced that it has expanded its Maybridge Ro3 Diversity Fragment Library, to make it an even more powerful tool for structure-based drug discovery. The new library adds 1,000 Ro3 (Rule of 3) compliant molecules, complementing the 1,500 compounds introduced last year. This expansion increases the diversity of the library by more than 30
Thermo Fisher Scientific Enables Ireland’s First Fragment-Based Screening Prog …
University of Dublin Selects Maybridge Ro3 Diversity Fragment Library for Drug Discovery Thermo Fisher Scientific Inc., the world leader in serving science, today announced that the University of Dublin has purchased the Maybridge Ro3 Diversity Fragment library for use in a new drug discovery program. As an institution known for its world-class biomedical research, the University is the first organization in the Republic of Ireland to undertake a fragment-based screening
Thermo Fisher Scientific Introduces “Off the Shelf” Fragment Library for Tim …
Maybridge Ro3 Diversity Fragments now available in prepared stock solution format for convenient use at the bench top Thermo Fisher Scientific Inc., the world leader in serving science, today announced that the Maybridge Ro3 Diversity Fragment Library is now available in a new prepared format, with each compound pre-dissolved as a DMSO solution. A gold standard for lead generation, the Maybridge Ro3 Diversity Fragment Library contains a broad range of 1,500