Renal Denervation Market Analysis by Top Manufacturers - Ablative Solutions, Inc., Boston Scientific Corporation, Cardiosonic Ltd, Kona Medical, Inc., Medtronic plc, & Many Others

The Renal denervation market size was estimated $197 million in 2015, and is expected to reach $3,153 million by 2022, with a CAGR of 48.5%. Renal denervation is a minimally invasive catheter-based procedure to treat hypertension. The procedure is generally opted in cases where drug therapies are unable to provide relief. It includes ablation of the nerves of renal artery wall by the use of radiofrequency pulses or ultrasound. This reduces sympathetic kidney activity, which further leads to a reduced blood pressure.

The global renal denervation systems market is poised to witness a steady growth during the forecast period. This is expected to be driven by major factors such as rising prevalence of hypertension, increasing geriatric population, clinical advantages such as fast recovery time with minimal complications, technological advancements to develop alternative technologies. Moreover, increasing clinical trials to validate clinical efficacy of renal denervation and cost effectiveness of the procedure over conventional surgeries are expected to offer high growth opportunities for players active in the global renal denervation systems market.

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Product Insights

According to the analysis carried out for each segment, the Symplicity Renal Denervation System accounted for the largest market share in 2015. Symplicity is the major and most frequently used product of the renal denervation market. According to the CIRSE Member Survey (2013), Symplicity is used by approximately 78% of the European hospitals. This system is generally preferred as it delivers low level of RF energy and thus reduces the potential risks associated with high levels of RF radiation on body tissues. Above all, the device provides a minimally invasive method to treat excessive hypertension. In addition, the Vessix Renal Denervation System is expected to have the highest growth rate as it uses a full-color graphic user interface that increases the accuracy and operation of the device. This feature enables the Vessix system to be a preferred system by physicians as well as patients.

Technology Insights

On the basis of technology, the market is segmented into radiofrequency, ultrasound and micro-infusion based renal denervation. The radiofrequency segment held 75.15% of the total market share in 2017, owing to its advantages, such as safety and time efficiency. Ultrasound segment is anticipated expand at the highest CAGR as it overcomes the limitations of radiofrequency based systems. Ultrasound energy with high-frequency sound waves ablate the nerves without getting in direct contact with the tissues, thus reducing injuries to the renal arteries.

Regional Insights

North America is projected to follow Europe, in terms of revenue generation, during the forecast period due to the rising number of filings for FDA approvals in U.S. For instance, Medtronic has received FDA approval to start an Investigational Device Exemption (IDE) pivotal trial for evaluating the Symplicity Spyral renal denervation system in the patients with hypertension. Increasing incidence of uncontrolled hypertension is also one of the key factors responsible for the region's growth.

Asia Pacific (APAC) region is anticipated to witness the fastest growth over the forecast period due to rising cases of diabetes, obesity, and other lifestyle diseases. Moreover, the presence of a large target population base in developing economies like Japan and China are the main drivers for the market growth in APAC.

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Leading market players

Key players have adopted product development as their key strategy to cater to the changing needs of the industry. Major players operating in this market include Ablative Solutions, Inc., Boston Scientific Corporation, Cardiosonic Ltd, Kona Medical, Inc., Medtronic plc, Mercator MedSystems, Inc., ReCor Medical, Inc., Renal Dynamics Limited, St. Jude Medical, Inc., and Terumo Medical Corporation. As of 2015, Medtronic dominated the overall renal denervation market, followed by St. Jude Medical.

TABLES OF CONTENT

CHAPTER 1 INTRODUCTION
1.1 Report description
1.2 Key benefits
1.3 Key market segments
1.4 Research methodology
1.4.1 Secondary research
1.4.2 Primary research
1.4.3 Analyst tools and models

CHAPTER 2 EXECUTIVE SUMMARY
2.1 CXO perspective

CHAPTER 3 MARKET OVERVIEW
3.1 Market definition and scope
3.2 Key findings
3.2.1 Top investment pockets
3.2.2 Top winning strategies
3.2.2.1 Competitive intelligence of companies and their strategies
3.3 Porters five forces analysis
3.3.1 Bargaining power of the suppliers
3.3.2 Bargaining power of buyers
3.3.3 Threat of new entrants
3.3.4 Competitive rivalry
3.3.5 Threat of substitutes
3.4 Market share analysis, 2015
3.5 Market dynamics
3.5.1 Drivers
3.5.1.1 Prevalence of hypertension
3.5.1.2 Changing lifestyle of people
3.5.1.3 Improvement of healthcare infrastructure in developing countries
3.5.1.4 Cost effectiveness of the procedure
3.5.2 Restraints
3.5.2.1 Painful procedure
3.5.2.2 Stringent approval process for renal denervation devices
3.5.3 Opportunities
3.5.3.1 Applications of renal denervation in other diseases
3.5.3.2 Clinical Trials
3.6 Clinical trials
3.6.1 The Symplicity clinical trial program
3.6.1.1 SYMPLICITY HTN-1
3.6.1.2 SYMPLICITY HTN-2
3.6.1.3 SYMPLICITY HTN-3
3.6.1.4 Global SYMPLICITY Registry
3.6.1.5 SYMPLICITY-HF
3.6.1.6 Symplicity Spyral(TM) Catheter Feasibility Study
3.6.1.7 HTN-Japan
3.6.1.8 SYMPLICITY HTN-India
3.6.2 Clinical trials for EnligHTN renal denervation system
3.6.2.1 EnligHTN I Trial
3.6.2.2 EnligHTN II Trial
3.6.2.3 EnligHTN III Trial
3.6.2.4 EnligHTN IV Trial
3.6.2.5 EnligHTNment Trial
3.6.3 Other clinical trials

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