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Update 2019 Oral Biologics Market Revenue | Growth Rate |Top Players Novo Nordisk A/S, Biocon Limited, Oramed Pharmaceuticals, Inc., Rani Therapeutics, Entera Bio Ltd., Allergan plc, Emisphere Technologies, Inc., Enteris BioPharma, Inc

10-10-2019 08:02 AM CET | Health & Medicine

Press release from: Coherent Market Insights

Oral Biologics

Oral Biologics

Increasing research and development activities and frequent strategic partnership between key players for development of novel oral biologics are expected to support the global oral biologics market growth.

For instance, Oramed Pharmaceuticals, based in Jerusalem, Israel, developed an innovative oral insulin capsule, transforming injectable treatments into oral therapies. In October 2018, they enrolled the first patient in an exploratory clinical study of its oral insulin capsule, ORMD-0801, for treating nonalcoholic steatohepatitis (NASH).

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Frequent partnership and collaboration activities by key players for the development of novel oral biologics is expected to form a conducive environment and significantly support global oral biologics market growth over the forecast period.

For instance, in 2018, Amgen Inc. entered into a deal with Entera Bio Ltd., to develop oral formulations of biologics. As per the deal, Amgen gained access to Entera's technology to develop an oral formulation of a large molecule, as well as an option to develop two other (oral) large molecules.

Oral biologics are also in clinical trial for rare conditions such as Hyperoxaluria and Acromegaly. In Acromegaly, oral drug would be injectable, however, there are no approved drugs for Hyperoxaluria. This high unmet need in Hyperoxaluria presents a significant market opportunity for oral enzyme i.e. Reloxaliase (ALLN-177). The drug is in Phase 3 and is expected to be filed with U.S. FDA in 2020.

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Furthermore, oral delivery of biologics has witnessed some major setbacks. For instance, in 2016, Novo Nordisk A/S discontinued the trials for oral insulin due to unsatisfactory result in clinical trials, and same year Bristol-Myers Squibb discontinued the collaboration with Biocon for the development of oral insulin. These two events suggest that development of oral biologics would not be an easy path for other companies, as well.

Significantly, large molecules such as monoclonal antibodies, fusion proteins, and others are difficult to administer orally. However, few companies have taken this challenge and are working in this direction. For instance, Protalix Biotherapeutics’ OPRX-106, a fusion protein is in Phase 2 for the treatment of inflammatory bowel disease (IBD). VHsquared Ltd. and Applied Molecular Transport, LLC are few other companies working in this domain.

Major players operating in the global oral biologics market include Novo Nordisk A/S, Biocon Limited, Oramed Pharmaceuticals, Inc., Rani Therapeutics, Entera Bio Ltd., Allergan plc, Emisphere Technologies, Inc., Enteris BioPharma, Inc., Chiasma, Inc., and Allena Pharmaceuticals, Inc.

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About Coherent Market Insights:
Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.

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