Plant-based Vaccines Market 2019: Develop Rapidly by Top Players Medicago, Inc., iBio, Inc., and Icon Genetics- GmbH

Existing key players and new entrants in the plant-based vaccines market are focused on extensive clinical trial studies to develop plant-based vaccines for numerous therapeutic applications.

For instance, Medicago Inc., a clinical-stage biotechnology company, which uses plant-based technologies to develop and produce novel vaccine and antibodies, is cultivating several tobacco plants (Nicotiana tabacum) at Durham's Research Triangle Park, North America, which will be used in testing and production of the flu vaccine. In March 2018, Medicago conducted phase III clinical trials to develop flu vaccine, which is expected to be launched in the market by 2020-21 influenza season.

For instance, in August 2018, researchers from Arizona State University’s (ASU) Biodesign Institute, developed a norovirus vaccine from tobacco plant. Genetic engineering has allowed researchers to transfer specific genes from tobacco plant in designing plant-based vaccine for norovirus. Plant-based vaccine safe and effective for use against various infectious diseases as it activates patient’s immune system.

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In June 2018, researchers from the University of Nottingham, Malaysia, announced a project to develop plant-based vaccine for treatment of dengue fever, caused by Aedes genus mosquitoes. The researchers produced vaccine antigen within the tobacco plant, which can neutralize dengue virus. Moreover, utilization of plant source in virus production offers new platform to provide vaccine that can be taken orally, as currently available vaccines are mostly given intravenously.

Other than tobacco plant, researchers are also working on edible plant species such as lettuce for future vaccine production. Successful completion of research studies would offer a safe and cost effective treatment to prevent dengue.

For instance, according to the Journal of Botany: March 2016, the dengue virus vaccine targeting dengue-3 serotype polyprotein (DENV3prM/E) was produced in Lactuca sativa (lettuce) through a chloroplast transformation. It is further concluded that, lettuce is an excellent host for agroinfiltration with deconstructed viral vectors.

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Key players operating in the global plant-based vaccines market include, Medicago, Inc., iBio, Inc., and Icon Genetics- GmbH.

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