What's driving the Protein Expression Systems Market growth? Key Players are:  Agilent Technologies, Inc., Becton, Dickinson & Company, Lonza Group Ltd., GenScript Biotech Corporation

The demand for protein therapeutics has increased considerably, owing to increase in prevalence of chronic diseases and development of plasma-derived therapies. In recent years, proteins expression systems have gained significant traction for therapeutic applications and the number of proteins launched or approved into clinical trials has continually increased. According to the National Center for Biotechnology Information (NCBI) data of 2017, the U.S. Food and Drug Administration (FDA) approved more than 140 recombinant therapeutic proteins for human use and several hundred are currently in development.

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However, high cost associated with therapeutic proteins and stringent government regulations towards approval of protein therapies are expected to hinder market growth. For instance, in India, a vial of Avastin (Bevacizumab mostly produced by the mammalian cell expression system), a monoclonal antibody, cost between US$ 372.65 to US$ 402.46. Moreover, immunogenicity is also a major concern for all recombinant drugs, as all biotechnologically produced therapeutics may exhibit some form of immunogenicity.

However, high cost associated with therapeutic proteins and stringent government regulations towards approval of protein therapies are expected to hinder market growth. For instance, in India, a vial of Avastin (Bevacizumab mostly produced by the mammalian cell expression system), a monoclonal antibody, cost between US$ 372.65 to US$ 402.46. Moreover, immunogenicity is also a major concern for all recombinant drugs, as all biotechnologically produced therapeutics may exhibit some form of immunogenicity.

Currently, most of all recombinant therapeutic proteins are produced in mammalian cells, mammalian cells are capable of producing high-quality proteins similar to the naturally occurring ones. Furthermore, many approved recombinant therapeutic proteins are generated in E. coli. (Bacteria) due to its well-characterized genetics, rapid growth, and high-yield production.

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Pharmaceutical companies are progressively focusing on research using proteins to develop novel effective therapeutics. Advances in molecular control of gene expression are also expanding the opportunities for protein expression systems. The next generation expression systems are gaining traction as drug manufacturers are looking for cheaper ways to express new biologic drugs. For instance, on 6 December 2018, AMSBIO introduced ALiCE, a new high-yield cell-free protein expression system. ALiCE is a unique eukaryotic system, which yields an unprecedented 3 mg/ml of protein in batch mode.

The production of proteins in appropriate quantity and quality is an essential requirement of the biopharmaceutical and biotechnology industry. Therapeutic proteins provide important therapies for a variety of diseases such as anemia, diabetes, cancer, infectious diseases, and hemophilia. There is a growing demand for recombinant proteins for therapeutic applications. Common therapeutic proteins include antibodies, anticoagulants, hormones, FC fusion proteins, interleukins, and enzymes. Human proteins obtained through genetic engineering play a crucial role in therapeutic medicines.

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Key players operating in the global protein expression systems market include Agilent Technologies, Inc., Becton, Dickinson & Company, Lonza Group Ltd., GenScript Biotech Corporation, Bio-Rad Laboratories, Inc., Merck KGaA, QIAGEN N.V., Thermo Fisher Scientific Inc., Takara Bio Inc., Synthetic Genomics Inc., Lucigen Corporation, Promega Corporation, ARTES Biotechnology GmbH, ProteoGenix, Addgene Inc., Geneva Biotech, Profacgen, and Peak Proteins Ltd.

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