Cell Culture Monitoring Biosensors Making New Commitments to the Sustainable Future with Top players C-CIT Sensors AG, Sarissa Biomedical, Lonza, Lifeonics, Nova Biomedical and Conductive Technologies

Personalized medicine is at cusp of making rapid strides in the global pharmaceuticals market. This novel treatment method would potentially benefit a large population affected by chronic diseases such as diabetes, cancer, respiratory disorders, and neurological disorders. Developing personalized therapy requires understanding the patient’s genetic composition, identifying a biomarker, and multiplication of cells or tissues. Cell culture is the prominent method for cell growth. Moreover, advancements in cell culture techniques, such as the 3D cell culture, has further encouraged extensive use of this technique in medical research.

Researchers monitor cell growth at regular intervals and terminate cell growth when desired growth or number of cells (cell density) is achieved. Manual monitoring of cell culture is time consuming and is associated with high human error risk. Therefore, a device or analyzer that can continuously monitor the cell culture without requiring manual intervention could help reduce error and save time. Electrochemical biosensors and fiber optic biosensors are deployed in cell culture monitoring analyzers, enabling various parameters such as temperature, cell density, and cell growth. Awareness about such automated cell culture monitoring devices and analyzers will spur growth of the cell culture monitoring biosensors market.

The global cell culture monitoring biosensors market was valued at US$ 214.7 million in 2015 and is expected to witness a moderate CAGR of 10.0% during the forecast period (2016 – 2024).

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An electrochemical biosensor is an integrated device capable of providing accurate analytical information that may be quantitative or semi-quantitative, by using a biochemical receptor, which is a biological recognition element that retains direct spatial contact with an electrochemical transduction element. The combination of electrochemistry biomedical sensors and microfluidics is an emerging application in cell culture monitoring market. These are further integrated together with each other to extract better results in various domains of cell culture, tissue engineering, and regenerative medicine.

Biosensors made by combination of microfluidic and electrochemistry are particularly useful for integration of cell culture with analysis and extraction of valuable insights. For instance, voltammetric and amperometric biosensors have been incorporated into microfluidic systems for H2O2 generation by cellular activities using HRP. In 2014, according to Hindawi Publishing Corporation and BioMed Research International, the thermometric, magnetic, and piezoelectric transducers were not exert a practical impact in the applications of tissue engineering and regenerative medicine. The gradual success of optical-fiber sensors is attributed to their application in tackling difficult measurement situations where conventional sensors do not provide the required accuracy. Furthermore, these sensors are usually compact, lightweight with effectively multiplexed on a single fiber network along being with minimally invasive.

Electromagnetic interference do not affect the results, as they do not have electrical current flowing at the sensing point, which could interfere with the reading. Fiber optic biosensors can also survive in difficult environments and are compatible with wide range of physical situations such as high doses of radiation, which favors its market revenue growth in the nuclear medicine industry.

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