Wilsons Disease Treatment Market – Rapid advancements in technology By Leading Companies: Valeant Pharmaceuticals, Wilson therapeutics, tsumura & Co., Merck & Co., VHB Life Science Inc., and Teva Pharmaceuticals USA, Inc

Rising incidence of Wilson’s disease is due to increase in the population worldwide as Wilson’s disease is a rare genetic disorder which, is expected to favor the demand for Wilson’s disease treatment market around the globe.

According to the European Association for the study of liver (EASL) in 2011 published that Wilson’s disease is a genetic disorder that is found worldwide and is recognized to be more common than previous, with a gene frequency of 1 in 90 -150 and an incidence that is 1 in 30,000 and more than 500 distinct mutations are described in the Wilson’s gene from which 380 have a confirmed role in the pathogenesis of the disease. Whereas, European Association also stated in year 2011 that Wilson’s disease accounts for 6 - 12% of all patient with acute liver failure who are referred for emergency transplantation.

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Manufacturers are focusing on drug innovation to tap into emerging markets of Asia Pacific, given their increasing spending on healthcare. For instance, Valeant Pharmaceuticals International Inc. announced the support regarding Wilson’s disease by providing US$ 100,000 fund for patient awareness and research into the treatment of Wilson’s disease. Whereas, Valeant Pharmaceuticals International. Inc. also sells its medication for Wilson’s disease under the Valeant coverage plus policy that assists customers to identify the best cost saving options. Furthermore, small manufacturers are launching tablets for Wilson’s disease under the licensed agreement with big manufacturers for example, Noblepharma Co., Ltd. Launched Nobelzin tablets under the licensed agreement with TEVA Pharmaceuticals.

Furthermore, manufacturers are also involved in R&D for novel drugs and vaccine. For instance in 2016, Merck & Co., Inc. invested US$6.8 Bn on research and development.

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Wilson disease is caused due to an inherited autosomal recessive mutation and in an autosomal recessive disease the child has to inherit the gene mutation from both parents, which increases the likelihood for the disease as the chance of inheriting autosomal recessive mutations from parent with gene mutation is one in four or 25%. Furthermore, both men and women develop Wilson’s disease at equal rate and symptoms for Wilson’s disease appear between ages 5 to 35. Increasing number of population is expected to drive growth of the Wilson’s disease treatment market over the forecast period, majorly in densely populated economies such as China and India. Increasing awareness and high expenditure on healthcare is also expected to fuel growth of the Wilson’s disease treatment market.

Various medications such as D-Penicillamine, trientine, zinc, tetrathiomolybdate can be used for treatment of Wilson’s disease. Furthermore, adoption of healthy diet and nutrition with medications can accelerate treatment of the Wilson’s disease. Moreover, liver transplantation can be conducted as a part of treatment if other treatments are not effective, as liver transplantation is necessary if cirrhosis leads to liver failure or acute liver failure.

Some major players operating in the Wilson’s disease treatment market are Valeant Pharmaceuticals International, Inc., Noblepharma Co., Ltd., Wilson Therapeutics AB, Kadmon Holdings, Inc., Merck & Co., Inc., VHB Life Science Ltd., Teva Pharmaceuticals USA, Inc. and Tsumura & Co.

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Few growth restraining factors are due to diagnosing and less awareness regarding the symptoms of the Wilson’s disease among the people hampers growth of the Wilson’s disease treatment market.

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