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Hemophagocytic Lymphohistiocytosis (HLH) Therapeutics- Pipeline Analysis 2018, Clinical Trials & Results

Hemophagocytic Lymphohistiocytosis (HLH) Therapeutics-

Hemophagocytic lymphohistiocytosis (HLH) is a medical condition in which the human body develops large number of activated immune cells, known as macrophages and lymphocytes.

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Person suffering from HLH usually develop symptoms within the first month or year of life. The symptoms of HLH includes cytopenia, fever, enlarged liver or spleen, and neurological abnormalities.

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There are five sub-types of inherited HLH reported which are designated as familial HLH, types 1-5. Each subtype is caused by different gene mutation. The genetic cause of type 1 HLH is currently unknown.

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Types 2-5 HLH are caused by mutations in the PRF1 gene, the UNC13D gene, the STX11 gene and the STXBP2 gene, respectively. The treatment of HLH depends on a number of factors, including the severity of symptoms, the age of onset, and the underlying cause of the condition.

• The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with the detailed analysis of pipeline and clinical trials.
• Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licensing, grants, technology, and others.

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