Betaxolol Market Modest Situation Among the Top Manufacturers Novartis AG, Genix Pharma, East West Pharma, Hetero Healthcare, Cadila Pharmaceuticals

Organic and inorganic strategies by market players such as merger, collaboration, acquisition, and research and development for expansion of their business across the regions is expected to boost growth of the market. For instance, in 2016, Humanwell Healthcare Group and PuraCap Pharmaceutical acquired Epic Pharma LLC for $550 million to expand both their commercial and manufacturing capabilities, as well as their presence in the U.S. and international generics market.

The market players operating in betaxolol market include Novartis AG, Genix Pharma (Pvt.) Ltd., East West Pharma, Hetero Healthcare Ltd. (GenX), Cadila Pharmaceuticals Ltd., Jawa Pharmaceuticals (INDIA) Pvt. Ltd., DAL Medical Services Company Ltd, Sentiss Pharma Pvt. Ltd., Humanwell Healthcare Group, and PuraCap Pharmaceutical LLC.

Increasing prevalence of hypertension diseases is also expected to drive growth of the market at significant rate. According to the reports from a variety of sources, including Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) in 2015, the global prevalence of pulmonary arterial hypertension is projected to be 100,000 – 200,000, that is about 15 - 50 patients per million of the population. Although treatment available for pulmonary arterial hypertension is limited, beta-adrenergic receptor inhibitor, Prostacyclin and prostacyclin analogs, phosphodiesterase-5 (PDE-5) inhibitors are available to decrease symptoms, slow down disease progression, and improve the quality of life.

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Betaxolol Market Restraint

Stringent regulatory approvals to ensure the safety of drugs and patent expiry of betaxolol drugs such as Betoptic S and Betoptic Liq, are major challenge for growth of the market, as the generic versions of these drugs are sold at 70% to 80% lower prices as compared to the branded drugs.

Betaxolol Market - Regional Analysis

Geographically, global betaxolol market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America holds the maximum share for ocular surgery, owing to high prevalence of diabetes and eye related disorders among the populace in the region. According to National Federation of the blind, 2014, around 1.3 million people were legally blind in the U.S. and estimated that over 75,000 people in the U.S. are expected to suffer from blindness or visual impairment annually. Furthermore, Asia Pacific betaxolol market is expected to witness significant growth owing to the presence of generic key players such as Lupin Ltd. And Cipla Ltd. especially in India, which are engaged in manufacturing the generics of betaxolol to retain the market share in the region.

Betaxolol is a racemic mixture and beta-adrenergic receptor inhibitor used to treat patients with chronic open-angle glaucoma or ocular hypertension. It was first approved by the U.S. Food and Drug Administration (FDA) in 1989, as an oral tablet. Betaxolol is used either alone or in combination with other medicines to lower down the pressure within the heart or eye. In the heart, Betaxolol decreases the cardiac contractility and rate selectively by actively binding and blocking beta-1 adrenergic receptors. This leads to reduction in cardiac output and lowers blood pressure. Topical applications in the eye reduces aqueous humor secretion and lowers the Intraocular Pressure (IOP) resulting in low risk of optic nerve damage and loss of vision in patients. Betaxolol further inhibits the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels. However, lightheadedness, drowsiness, dizziness, and headache are some of the symptoms reported while taking this medication at initial stage. For oral administration, Betaxolol is available as 10-mg and 20-mg tablets whereas in liquid form, it comes in 2.5, 5, 10, and 15 mL of bottles of 0.25% sterile ophthalmic suspension and prescribed as one to two drops in the affected eye twice daily.

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