Nimbus Discovery and Proteros enter into multi-target X-ray protein crystallography collaboration
Under the agreement, Proteros will provide structures from its Gallery Structure list, an ever growing catalogue of ready-to-use proteins (currently over one hundred) for rapid X-ray structure analysis of protein-ligand complexes in addition to providing gene-to-structure projects for novel biological targets. Proteros will deploy its high throughput crystallography platform and proprietary technologies to provide Nimbus with rapid turnaround in support of their discovery projects. Proteros will also generate customized structures for Nimbus’ proprietary programs and clinical candidates.
Proteros has no internal drug discovery programs and continues to focus and invest in developing its service business which consists of X-ray protein crystallography, kinetic and thermodynamic compound profiling and integrated lead discovery based on a fragment library of over 30,000 novel target directed molecules.
Cony D’Cruz, CBO and President of Proteros (US) Inc. said: “We are delighted to be working with an innovative company such as Nimbus. We look forward to using our proven expertise in crystallography to assist with Nimbus’ exciting discovery goals.”
”Our collaboration with Proteros Biostructures generates real-time structural data to accelerate our programs against fundamental disease targets”, added Jonathan Montagu, Vice President, Business Operations at Nimbus. ”Proteros is a key component of our virtually integrated, globally distributed R&D model”.
About Nimbus Discovery:
Nimbus Discovery is applying advances in computer-based drug discovery to develop new medicines against important drug targets and thereby unlock fundamental biological pathways. Nimbus has established a first-of-its-kind partnership with Schrödinger, the leader in computational drug discovery, to gain privileged access to cutting-edge technology and exclusive rights to key targets. Nimbus has already delivered selective, potent, and differentiated compounds within the first year for two disease targets that are pivotal in the progression of an aggressive form of Non-Hodgkin’s lymphoma and obesity, respectively. Nimbus has built a virtually integrated, globally distributed R&D organization that leverages an experienced internal drug discovery team across an external network of R&D partners. The resulting organization is scalable, capital efficient and has attracted world-class talent. Nimbus seeks to partner its programs with larger pharmaceutical companies early in the development process allowing Nimbus to focus on its competitive advantage in novel drug discovery. Nimbus programs are held in target-specific subsidiaries under an LLC umbrella. Nimbus Discovery was founded in 2009 by Atlas Venture and Schrödinger, Inc. In 2010, Nimbus received three Qualifying Therapeutic Discovery Project Tax Credit (QTDP) grants for its programs. For more information please visit www.nimbusdiscovery.com.
About Proteros biostructures GmbH:
Proteros is a privately held company that provides services and proprietary technologies to support integrated drug discovery. Proteros uses its technical expertise, industrial processes and unique technologies for crystallography, kinetic and thermodynamic profiling and fragment-based lead generation incorporating protein structure inspired compound and fragment libraries. The platform enables ‘knowledge driven lead engineering’ to accelerate and improve protein structure analysis and structure-based drug discovery. Proteros complements its clients’ internal capabilities with external expertise and access to flexible resources. Proteros currently provides services to more than 80 pharmaceutical and biotechnology clients in North America, Europe and Japan. Proteros US, Inc. is a wholly owned subsidiary of Proteros established to serve the growing customer base in North America.
Proteros biostructures GmbH
Kurt Herrenknecht, Ph.D.
Am Klopferspitz 19
Phone: +49 (0) 89 7007 61 - 0
Fax: +49 (0) 89 7007 61 - 15
Nimbus Discovery, LLC
Vice President, Business Operations
25 First Street, Suite 303
Cambridge, MA 02141
Phone: + 1 (617) 588-2600
Fax: +1 (617) 231-0652
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