Chronic Lymphocytic Leukemia: Opportunity Analysis, Experiments, Evolution, Fermentation, Research and Forecasts to 2027

This research study added to the broad database of Market Research Hub (MRH) focusing on the Chronic Lymphocytic Leukemia: Opportunity Analysis and Forecasts to 2027 delivers an in-depth outlook to present information about executive summary and key performance indicators. Furthermore, readers can gather knowledge about the economic status, demographics and competitive landscape which is prevailing in the concerned industry during the review period, 2027. Overall, the purpose of this assessment is to present a clear picture highlighting the transformations expected to occur in the Chronic Lymphocytic Leukemia driven by major trends and opportunities.

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Chronic Lymphocytic Leukemia: Opportunity Analysis and Forecasts to 2027

Summary

Chronic lymphocytic leukemia (CLL) is a form of cancer that originates from lymphocytes in the bone marrow and later invades the blood and/or lymphoid tissues. CLL treatment has been transformed since the novel oral targeted agents Imbruvica (ibrutinib), Zydelig (idelalisib), and Venclexta (venetoclax) were introduced to the market from 2014 onwards and challenged the prior dominance of chemoimmunotherapy regimens. During the forecast period, the global CLL market will welcome five new drugs-Calquence (acalabrutinib), zanubrutinib, umbralisib, ublituximab, and Revlimid (lenalidomide).

The CLL marketed is expected to experience modest growth in the 7MM (US, France, Germany, Italy, Spain, UK and Canada) from 2017-2027. This is driven by increasing incidence, driven primarily by aging populations, label expansions into the first-line setting for AbbVie/Roches Venclexta, frontline approval of the combination of AbbVie/Johnson & Johnsons Imbruvica + Venclexta, and the increasing use of combination therapies instead of monotherapies or chemoimmunotherapy regimens. Generic and biosimilar erosion of some of the mainstays of CLL treatment is also expected during the forecast period, particularly the use of generic ibrutinib and biosimilar rituximab will lead to a decline in sales. A lack of innovative drugs in the late-stage pipeline with novel mechanisms of action means that next-generation agents are not expected to generate significant sales.

Key Questions Answered

- Which pipeline agents are the most promising and expected to launch in the 7MM? What are the forecasted sales of these agents and what will be their impact in the CLL market?
- What are the main unmet needs in CLL, which pipeline drugs will fulfil these needs, and to what extent?
- What are the current research and development (R&D) strategies being explored and how can developers incorporate these methods into their business strategy?

Scope

- Overview of CLL, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and disease management.
- Annualized CLL therapeutics market revenue, cost of therapy per patient, and treatment usage patterns in seven geographic regions, forecast from 2017 to 2027.
- Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping and implications for the CLL therapeutics market.
- Pipeline analysis: comprehensive data assessing emerging trends and mechanisms of action under development for CLL. The most promising candidates in late-stage development are profiled.
- Analysis of the current and future market competition in the global CLL market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.

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Table of Contents

1.1 List of Tables
1.2 List of Figures
2 Chronic Lymphocytic Leukemia: Executive Summary
2.1 Modest Growth in the CLL Market Expected from 2017-2027
2.2 Combinations of Targeted Drugs
2.3 Unmet Needs Exist in CLL, Particularly for Therapies of Fixed Duration as Well as More Efficacious Therapies for Patients with Adverse Prognostic Features
2.4 Commercial Opportunity for Therapies that Provide a Cure
2.5 Late-Stage Pipeline Agents to Have Low Impact on the Future CLL Treatment Landscape
2.6 What Do Physicians Think?
2.6.1 Defined Course of Treatment
2.6.2 Combination Therapies
2.6.3 Measuring Minimal Residual Disease Negativity
2.6.4 Therapies with Curative Potential
2.6.5 Chimeric Antigen Receptor-T Cell Therapy
2.6.6 PD-1/PD-L1 Checkpoint Inhibitors
3 Introduction
3.1 Catalyst
3.2 Related Reports
3.3 Upcoming Related Reports
4 Disease Overview
4.1 Etiology and Pathophysiology
4.1.1 Etiology
4.1.2 Pathophysiology
4.2 Rai and Binet Staging Systems

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