Press release
Anophthalmia-Microphthalmia Market Growing with 6.4% CAGR Accounting Millions of Business by 2025 With Key Players Like Bristol-Myers Squibb Company, Nusapure, Allergan, Aerie Pharmaceuticals, Pfizer, Valeant Pharmaceuticals International
The Global Anophthalmia and Microphthalmia Market accounted to USD xx million in 2017 growing at a CAGR of 6.4% during the forecast period of 2018 to 2025. The upcoming market report contains data for historic years 2015, the base year of calculation is 2017 and the forecast period is 2018 to 2025.The global Anophthalmia and Microphthalmia market is highly fragmented and is based on new product launches and clinical results of products. Hence the major players have used various strategies such as new product launches, clinical trials, market initiatives, high expense on research and development, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of Anophthalmia and Microphthalmia market for global, Europe, North America, Asia Pacific and South America.
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Key Anophthalmia and Microphthalmia Market Competitors:
• Bristol-Myers Squibb Company
• Nusapure
• Allergan
• Aerie Pharmaceuticals
• Pfizer
• Valeant Pharmaceuticals International
• Bayer AG
• Genentech
• Novartis AG
• Regeneron Pharmaceuticals
• Shire
• Santen Pharmaceutical
Anophthalmia and microphthalmia describe, respectively, the absence of an eye and the presence of a small eye within the orbit. The combined birth prevalence of these conditions is up to 30 per 100,000 population, with microphthalmia reported in up to 11% of blind children. High-resolution cranial imaging, post-mortem examination and genetic studies suggest that these conditions represent a phenotypic continuum. Both anophthalmia and microphthalmia may occur in isolation or as part of a syndrome, as in one-third of cases. Anophthalmia/microphthalmia have complex aetiology with chromosomal, monogenic and environmental causes identified. Chromosomal duplications, deletions and translocations are implicated. Of monogenic causes only SOX2 has been identified as a major causative gene. Other linked genes include PAX6, OTX2, CHX10 and RAX. SOX2 and PAX6 mutations may act through causing lens induction failure. FOXE3 mutations, associated with lens agenesis, have been observed in a few microphthalmic patients. OTX2, CHX10 and RAX have retinal expression and may result in anophthalmia/microphthalmia through failure of retinal differentiation. Environmental factors also play a contributory role. The strongest evidence appears to be with gestational-acquired infections, but may also include maternal vitamin A deficiency, exposure to X-rays, solvent misuse and thalidomide exposure. Diagnosis can be made pre- and post-natally using a combination of clinical features, imaging (ultrasonography and CT/MR scanning) and genetic analysis. Genetic counselling can be challenging due to the extensive range of genes responsible and wide variation in phenotypic expression. Appropriate counselling is indicated if the mode of inheritance can be identified. Differential diagnoses include cryptophthalmos, cyclopia and synophthalmia, and congenital cystic eye. Patients are often managed within multi-disciplinary teams consisting of ophthalmologists, paediatricians and/or clinical geneticists, especially for syndromic cases. Treatment is directed towards maximising existing vision and improving cosmesis through simultaneous stimulation of both soft tissue and bony orbital growth. Mild to moderate microphthalmia is managed conservatively with conformers. Severe microphthalmia and anophthalmia rely upon additional remodelling strategies of endo-orbital volume replacement (with implants, expanders and dermis-fat grafts) and soft tissue reconstruction. The potential for visual development in microphthalmic patients is dependent upon retinal development and other ocular characteristics.
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Market Segmentation: Global Anophthalmia and Microphthalmia Market
• By diagnosis the global Anophthalmia and Microphthalmia market is segmented into CT Scan, MR Scan, Chromosome Analysis, and Ultrasonography.
• By end-users the global Anophthalmia and Microphthalmia market is segmented into hospitals & clinics, and research centers.
• On the basis of geography, global Anophthalmia and Microphthalmia market report covers data points for 28 countries across multiple geographies such as North America & South America, Europe, Asia-Pacific, and Middle East & Africa. Some of the major countries covered in this report are U.S., Canada, Germany, France, U.K., Netherlands, Switzerland, Turkey, Russia, China, India, South Korea, Japan, Australia, Singapore, Saudi Arabia, South Africa, and Brazil among others. In 2017, North America is expected to dominate the market.
Major Market Drivers and Restraints:
• Growing prevalence of the genetic disorders
• Rising eye-related disorders
• Pain and complications during surgery
• Availability of expensive treatment
• Poor reimbursement policies
Data collection and base year analysis is done using data collection modules with large sample sizes. The market data is analyzed and forecasted using market statistical and coherent models. Also market share analysis and key trend analysis are the major success factors in the market report. To know more please Request an Analyst Call or drop down your inquiry.
Demand Side Primary Contributors: Doctors, Surgeons, Medical Consultants, Nurses, Hospital Buyers, Group Purchasing Organizations, Associations, Insurers, Medical Payers, Healthcare Authorities, Universities, Technological Writers, Scientists, Promoters, and Investors among others. Supply Side Primary Contributors: Product Managers, Marketing Managers, C-Level Executives, Distributors, Market Intelligence, and Regulatory Affairs Managers among others.
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