2019 Industry Insights on Protein A Resins Market | Key Players: Thermo Fisher Scientific, Tosoh Bioscience, Inc, Bio-Rad Laboratories, Expedeon Inc. US, Danaher Corporation, EMD Millipore, GE Healthcare, Sigma-Aldrich

Recombinant protein A resins segment of protein A resins market dominated the industry over forecast timeframe. Recombinant protein A is formulated in E.Coli and functions same as that of natural protein A resins. However, recombinant form of protein is preferred where other production source offers less non-specific binding.

Natural protein A resins provides high capacity antibody purification but are sensitive to alkaline conditions. Due to sensitivity to alkaline conditions, cleaning in place (CIP) of natural a protein resins with 0.1M or 1M NaOH is not feasible. Thus, alternative CIP must be used that in turns increase the overall cost of procedure.

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Immunoprecipitation application segment of protein A resins market is forecasted to witness robust growth rate over forthcoming years. Immunoprecipitation is widely applicable in research and development sector. As protein A resins are used in immunoprecipitation technique its demand is forecasted to go hand in hand with increasing demand for immunoprecipitation.

Antibody purification segment of protein A resins market accounted for largest revenue share in 2017 and is forecasted to continue to dominate the industry in near future. The increasing demand for therapeutic antibodies and high research and development activities in the antibody field will escalate the segment growth to some extent.

Company profiled in this report based on Business overview, Financial data, Product landscape, Strategic outlook & SWOT analysis:
 Expedeon Inc. US
 Agarose Bead Technologies ABT
 Danaher Corporation
 Bio-Rad Laboratories
 EMD Millipore
 GE Healthcare
 Sigma-Aldrich Novasep, Repligen Corporation
 Takara Bio USA, Inc
 Thermo Fisher Scientific
 Tosoh Bioscience, Inc

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Ongoing progress in antibody engineering has led to the development of different types of antibodies with variety of clinical applications. Regulatory authorities are approving considerable number of monoclonal antibodies from past few years to cater to its increasing demand. Moreover, significant number of antibodies are still in investigational phase that are expected to receive approval in coming years. This will escalate protein A resin’s demand for large scale purification of these antibodies.

Spur in the usage of chromatographic techniques for determination of vitamins and identification of additives in food will shoot protein A resins market growth over forecast timeframe. Chromatography is undoubtedly superior technique of separation compared to older techniques such as solvent extraction. Moreover, the technique even has application in forensic science. Such wide range of application will fuel the industry growth.

However, high cost of protein A resins is predicted to impede industry growth to some extent over forecast timeframe. High price of certain resins that lines columns, makes chromatography an expensive technique. High price affects affordability as well as adoption rates of protein A resins rendering negative impact on industry growth.

Glass or silica gel-based matrix segment of protein A resins market is forecasted to witness healthy growth over the forecast timeframe due to improved durability, mechanical strength and ability to incorporate high absorption of metallic dopants.

However, agarose-based matrix type accounted for largest revenue share in 2017 and is expected to dominate the industry throughout the forecast period. Suitable pH range, good resolution at minimum time, high flow rate makes these types of beads perfect for process scale practices.

Biopharmaceutical firms uses protein A resins extensively for large scare purification of monoclonal antibodies. Production of therapeutic monoclonal antibodies by biopharmaceutical firm is forecasted to rise to cater to its increasing demand. With the rising production of monoclonal antibodies, demand for protein A resins will grow for the large-scale purification.

Along with biopharmaceutical firms, usage of protein A resins is also increasing in research sector. Growing trend of outsourcing large-scale production to contract research organization will augment CROs end user segment growth over the forecast period.

U.S. accounted for largest regional share in 2017 due to robust research and development in the field of drug discovery and ongoing inflow of approved monoclonal antibodies in the protein A resins market. Technological advancements coupled with the availability of funding for research on novel therapies will further render significant positive impact growth.

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Japan protein A resins market dominated the Asia Pacific region in 2017 due to increasing demand for novel therapies to combat with chronic diseases. Well-developed pharmaceutical sector and healthcare infrastructure, and ongoing research and development activities will augment Japanese protein A resins market.

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