In Situ Hybridization Market Detail Analysis focusing on Key Players like Leica Biosystems Nussloch GmbH • Thermo Fisher Scientific • F. Hoffmann-La Roche AG • Abbott Laboratories • Agilent Technologies • PerkinElmer • Qiagen / Exiqon A/S •

The ‘In Situ Hybridization market’ research collated by Market Study Report, LLC, offers a comprehensive analysis of growth trends prevailing in the global business domain. This report also provides definitive data concerning market, size, commercialization aspects and revenue forecast of the industry. In addition, the study explicitly highlights the competitive status of key players within the projection timeline while focusing on their portfolio and regional expansion endeavors.

In Situ Hybridization: Market Shares, Strategy, and Forecasts, Worldwide, 2018 to 2024. The 2018 study has 242 pages, 83 tables and figures. Worldwide markets are poised to achieve continuing growth as In Situ Hybridization is used in diagnostic situations to analyze single cells inside tissue. Managing single cell diagnostics in real time, encouraging collaborative business efforts. Lowering transaction management costs is a key benefit.

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In situ hybridization (ISH) is a type of hybridization that uses a labeled complementary DNA, RNA or modified nucleic acids strand (i.e., probe) to localize a specific DNA or RNA sequence in a portion or section of tissue (in situ), or, if the tissue is small enough (e.g., plant seeds, Drosophila embryos), in the entire tissue (whole mount ISH), in cells, and in circulating tumor cells (CTCs).

Advances in RNA in situ hybridization transform molecular detection with morphological context enabling new applications. Scientists use RNA ISH to extract data dimensions.

Immunohistochemistry (IHC) and RNA in situ Hybridization are widely used technologies sharing the unique capacity to analyze a marker at the single cell level while preserving the morphological context. In different situations, IHC and ISH are used in conjunction to validate data or provide complementary information.

In situ hybridization (ISH) is a powerful technique for localizing specific nucleic acid targets within fixed tissues and cells, allowing users to obtain temporal and spatial information about gene expression and genetic loci. While the basic workflow of ISH is similar to that of blot hybridizations?the nucleic acid probe is synthesized, labeled, purified, and annealed with the specific target?the difference is the greater amount of information gained by visualizing the results within the tissue.

The global market for In Situ Hybridization (ISH) at $4.3 billion in 2017 is anticipated to reach $7.8 billion by 2024 2017. CAGR of 7.8% in the next five years (2017 to 2024). Increasing diagnosis and growing incidence & prevalence of cancer, technology advancements in therapeutics, increasing government initiatives globally are expected to drive the growth of the market in the coming years.

Companies Profiled

Market Leaders
• Leica Biosystems Nussloch GmbH
• Thermo Fisher Scientific
• F. Hoffmann-La Roche AG
• Abbott Laboratories
• Agilent Technologies
• PerkinElmer
• Qiagen / Exiqon A/S
• Merck KGaA
• BioGenex Laboratories
• BioTechne / Advanced Cell Diagnostics (ACD)

Key Topics
In Situ Hybridization
Molecular Diagnostics
Cervical Cancer Stain
Fish Steps Reduction
Fluorescence In Situ Hybridization (FISH)
In Situ Hybridization (ISH)
FISH Probe Kit
Cancer
Chromosonal Abnormalities
Infectious Diseases
Inflammatory Diseases
Fluorescence In Situ Hybridization (FISH)
Chromogenic In Situ Hybridization (CISH)
Human Genetic Tests
Microbial Tests
In Vitro Diagnostics
System for the Analysis of Solid Tumors
Hybridization Technique
Detection of Long Non-
Coding DNA
Coding RNA

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Table of Contents

US In situ Hybridization Executive Summary 15
In Situ Hybridization (ISH) 15
1. United States In Situ Hybridization ISH Market Definition and Market Dynamics 16
1.1 US In situ Hybridization Market Overview 16
1.1.1 Antibody Challenges and Validation 16
1.2 Scope of In situ Hybridization in Inflammation 17
1.2.1 RNAscope? Applications 17
2. In-Situ Hybridization Market Shares and Market Forecasts 20
2.1 In-Situ Hybridization Market Driving Forces 20
2.1.1 Identification of Cytokines and their Cellular Origins 21
2.1.2 Detection of Long Non-Coding RNA (lncRNA) in Inflammatory Diseases 21
2.1.3 Role of Inflammatory Pathways During Carcinogenesis 22
2.1.4 Therapeutic Potential Of Secreted Proteins In Inflammatory Diseases 22
2.1.5 Dual ISH-IHC Detect Cytokines During Inflammatory Responses 22
2.2 In Situ Hybridization Market Shares 24
2.2.1 Roche 25
2.2.2 Abbott Molecular 25
2.2.3 Advanced Cell Diagnostics 25
2.2.4 PerkinElmer In Situ Hybridization Market Driving Forces 26
2.2.5 In Situ Hybridization Market Shares, Unit Shipments and Kit Shipments 27
2.3 In Situ Hybridization Market Forecasts 29
2.3.5 In Situ Hybridization Market Segments, Units and Kits, Dollars and Percent, US, 29
2.4 In situ Hybridization Market Segments 31
2.4.1 In Situ Hybridization Market Shares, Dollars, Worldwide, 2012 to 2017 32
2.4.2 Fluorescence (FISH) and Chromogenic (CISH) Detection 33
2.4.3 ISH Applications 36
2.4.4 Multiplex Fluorescence In Situ Hybridization (FISH) 36
2.4.5 Fluorescence In Situ Hybridization (FISH) 37
2.4.6 Cancer Drug Market 40
2.4.7 Chronic Lymphocytic Leukemia (CLL) 40
2.4.8 In-Situ Hybridization Cancer Diagnosis, Cytology, Infectious Disease Molecular Diagnostic 42
2.1.6 In Situ Hybridization Market Segments, Diagnostic Laboratories, Academic & Research Institutes, Contract Research Organizations, and Pharmaceutical & Biotechnology Companies 47
2.5 In-Situ Hybridization Pricing 54
2.5.1 miRCURY LNA miRNA Detection Probes 54
2.5.2 Price and Availability 58
2.6 In-Situ Hybridization Geographical Analysis 61
3 In-Situ Hybridization Research and Technology 68
3.1 Hybridization Technique 68
4 In-Situ Hybridization Company Profiles 69
4.1 Abbott Laboratories 69
4.1.1 Abbott Laboratories Market Categorization 69
4.1.2 In Situ Hybridization Product Category, Application and Specification 70
4.1.3 Abbott Laboratories Vysis Chronic Lymphocytic Leukemia (CLL) FISH Probe Kit (IVD) 71
4.1.4 Vysis CLL FISH Probe Kit Contents 72
4.1.5 Acupath Laboratories Test For Detecting Bladder Cancer Uses Probes from Abbott Molecular 74
4.1.6 Abbott Laboratories Barrett?s Esophagus FISH 75
4.1.7 Abbott Molecular Vysis CLL FISH Probe Kit | 77
4.1.8 Abbott Laboratories Revenue 77
4.1.9 Abbott Laboratories ThermoBrite System 81
4.1.10 Abbott Laboratories User Programmable Settings 82
4.1.11 Abbott Laboratories Vysis FISH Chromosome Search 83
4.1.12 Abbott Laboratories Molecular Diagnostics 84
4.1.13 Abbott Diagnostic Products 85
4.2 Acupath Laboratories 87
4.2.1 Acupath Laboratories Barrett?s Esophagus FISH 88
4.3 Agilent Technologies 88
4.3.1 Agilent CGH & CGH+SNP Microarrays 91
4.3.2 Agilent Technologies Revenue 91
4.3.3 Agilent Diagnostics and Genomics 93
4.4 Bio-Techne / ACD 96
4.4.1 Bio-Techne ACD RNAscope Widely Used In-Situ Hybridization Technique 97
4.4.2 Bio-Techne Revenue 98
4.4.3 Biotechne US Regional Analysis 101
4.4.4 Advanced Cell Diagnostics 102
4.5 F. Hoffmann-La Roche AG 102
4.5.1 Roche Gene Amplification by Fluorescence In Situ Hybridization 104
4.5.2 Roche Automated RNA isolation 105
4.5.3 Roche Fluorescence In Situ Hybridization (FISH) 105
4.5.4 Roche Agreement with Merck Millipore Sigma 106
4.5.5 Roche Immuno Diagnostics 108
4.5.6 F. Hoffmann-La Roche AG Revenue 109
4.5.7 Roche Buys Flatiron Health Leader In Oncology-Specific Electronic Health Record (EHR) Software 114
4.6 Danaher / Leica Biosystems Nussloch GmbH 115
4.6.1 Leica Biosystems Nussloch GmbH BOND IHC/ISH Instruments 116
4.6.2 Leica Biosystems Nussloch GmbH Revenue 122
4.6.3 Danaher Geographical Revenue 124
4.7 Thermo Fisher Scientific 125
4.7.1 Thermo Fisher Scientific Fluorescence In Situ Hybridization (FISH) 125
4.7.2 Chromogenic In Situ Hybridization (CISH) 128
4.7.3 Thermo Fisher Scientific Revenue 133

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