Global Ion Chromatography Market 2019 Rise at a CAGR of 6% by 2023, Major Players: WATERS CORPORATION, THERMO FISHER SCIENTIFIC, AGILENT TECHNOLOGIES, SHIMADZU CORPORATION, GE HEALTHCARE

The global ion chromatography market is expected to register a CAGR of 6% during the forecast period of 2018-2023. Ion chromatography is a well-established technique for the analysis of anions and cations in liquid, gaseous, and solid samples. Organizations, such as the ISO, US EPA, ASTM, and AOAC have established their standards on regulatory methods of analysis using this technique. Currently, electrochemical and spectrometric methods are two detection methods applied in ion chromatography.

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Increasing Use of Ion Chromatography Technique in Purifying Monoclonal Antibodies (mAbs)
Monoclonal antibodies use has increased tremendously over the last decade, and estimates suggest that mAbs and their derivatives account for close to one-third of the biopharmaceuticals under development, including vaccines and gene therapy. Biopharmaceutical products must be pure, as any impurity can significantly affect the body’s response to that particular product and can lead to various unnecessary complications. Typically, this stringent purification is accomplished using a three-column chromatography process. It consists of protein A affinity chromatography process, cation exchange, and anion exchange chromatography. Protein A affinity chromatography is used as an initial capture step due to its high affinity for mAbs. However, protein A affinity chromatography costs higher, and hence, the overall process becomes cost-intensive. Various attempts are being made to make the process cost-effective, and one of the most effective ways of reducing cost significantly is using two-column ion exchange (cation and anion exchange) chromatography. In this, cation-exchange is used as the capture step, and anion exchange as the polishing step. The increasing use of ion exchange chromatography for purification, along with the growing demand for monoclonal antibodies is a primary driver for the ion chromatography market.
The other factors, such as increasing academic and commercial R&D spending on pharmaceuticals, increasing use of ion chromatography technique in food, beverage, and water industry, and the technological advancement in ion chromatography are driving this market.

Key Developments in the Market
• February 2018: New high pressure Ion chromatography system designed to deliver heightened performance by Thermo Fisher.
• December 2017: Thermo Fisher Scientific acquired the Phenom-World.

Top Players:
The major players include WATERS CORPORATION, THERMO FISHER SCIENTIFIC, AGILENT TECHNOLOGIES, SHIMADZU CORPORATION, GE HEALTHCARE, TOSOH CORPORATION, PERKIN ELMER, METROHM AG, MITSUBISHI CHEMICAL CORPORATION, and BIO-RAD LABORATORIES, INC., among others.

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High Cost of Instrument
High TCO (total cost of ownership) is one of the major restraints the ion chromatography market faces. On an average, any chromatography instrument or system is expected to cost an estimated USD 4000. The cost will increase when the system needs to be customized as per the working environment. The customization includes accessories that need to be purchased with it or customizing its sample handling settings or addition of any other features. The cost of the equipment also depends on the level of accuracy that the organization requires for processing, detection, and analyzing. Dionex ion chromatography systems range between USD 6000 u2014 10000. New investors and companies looking to expand always consider cost as a crucial factor in taking technology decisions. A new ion chromatography system is a large capital expenditure. It is often considered difficult to obtain budget approvals for large capital expenses. The high cost of the instrument is expected to restrain the ion chromatography market. The other factor, such as lack of skilled personnel to handle the equipment is hindering the market.

United States Leads the Market in North America
In 2017, the United States ion chromatography market held the largest share in North America. However, the Mexican market is expected to witness the fastest CAGR of 6.54% in North America.

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