In Vitro Toxicity Testing Market Overview with Top Key Players: ABBOTT LABORATORIES, INC., ACEA BIOSCIENCES, INC., AGILENT TECHNOLOGIES, INC., ALBANY MOLECULAR, RESEARCH, INC., APTUIT, INC., BIOGNOSYS AG, BIORELIANCE, BIOVIA, CELLULAR DYNAMICS INTERNATION
The global in vitro toxicity market should grow at a compound annual growth rate (CAGR) of REDACTED during the forecast period (2018–2023). Every year more chemicals are synthesized and are brought into the market. The cost of animal testing is high, with some substances costing more than several million dollars. Along with the high cost of toxicity testing, animal welfare is another key concern that calls for alternative testing methods. In vitro model systems, like cell-based models, can significantly reduce costs and the use of animals in toxicity testing. The increasing need for non-animal tests in toxicity testing is driving demand in the in vitro toxicity market. In vitro models are used to gain a better
in vitro toxicity testing market, in vitro toxicity testing market research, in vitro toxicity testing market forecast
understanding of chemical-induced toxicity in animals and humans. The in vitro test model primarily serves as a rapid screening system for the toxicologic evaluation of chemicals. These models may complement in vivo toxicity tests or may replace some in vivo models if scientifically validated and accepted by regulatory agencies.
Market Key Players are:
GE HEALTHCARE LIFE SCIENCES
IMQUEST BIOSCIENCES, INC.
LONZA GROUP LTD.
MOLECULAR DEVICES LLC
STEMINA BIOMARKER DISCOVERY, INC.
THERMO FISHER SCIENTIFIC, INC.
VALA SCIENCES, INC.
VISTAGEN THERAPEUTICS, INC.
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The most common in vitro models are isolated tissue preparations, perfused organ preparations, single cell suspensions, and cell-culture systems (like primary cell cultures) and mammalian cell lines. Cellculture systems often are used because they are reliable, reproducible, and relatively inexpensive testing methods that assess chemical toxicity at the cellular level. Further, non-animal toxicity test methods have been used for determining cellular toxicity by manufacturers to support decisions for conducting conventional animal testing.
The growing demand for in vitro toxicity testing during the drug discovery process and increasing number of contract research organizations (CRO) are major drivers of the global in vitro toxicity market. The Developmental Therapeutics Program at the National Cancer Institute (DTP 2005) developed an in vitro cell-line screen to support its drug-discovery program. For potential anticancer activity, the in vitro cell-line screen test can screen up to 20,000 compounds per year. The in vitro cell-line screen test uses 60 human tumor cell lines, representing various cancers such as skin cancer, breast cancer, colon cancer, brain cancer, prostate cancer, blood cancer, and kidney cancer.
Charles River, GVK Biosciences Private Ltd., Sekisui XenoTech LLC and Merck KGaA are among a large number of CROs that offer in vitro toxicity services. The increasing demand for animal-free toxicity tests driving growth of the global in vitro toxicity market. In vitro toxicity tests are reliable, cost-effective and do not use animals, unlike in vivo tests. The rising global prevalence of chronic diseases has significantly increased demand for the discovery of novel drugs. The toxicity study of drugs and compounds is performed by the regulatory bodies, in order to facilitate approval of drugs and devices.
High cost of toxicology equipment, inadequate infrastructure and funding for R&D in emerging countries are expected to hinder growth of the global in vitro toxicity market. High-throughput screening (HTS) equipment is expensive, particularly for small and emerging countries that wish to purchase multiple instruments. Their high cost may hinder market growth in these countries. However, governments, companies and research institutes are extensively funding for toxicology research, which should overcome the cost challenges and drive market growth during the forecast period. Also, regulatory programs such as TOX21, ToxCast program and NTP (National Toxicology Program) are creating
enormous opportunities for companies in the in vitro toxicity global market.
Table of Content:
Chapter 1 Introduction
Chapter 2 Summary and Highlights
Chapter 3 Market and Technology Background
Chapter 4 Market Breakdown by Toxicity Endpoints and Tests
Chapter 5 Market Breakdown by End-User Industry
Chapter 6 Market Breakdown by Tool/Technology
Chapter 7 Market Breakdown by Component
Chapter 8 Market Breakdown by Region
Chapter 9 Patent Review/ New Developments
Chapter 10 Company Profiles
List of Tables:
Global Market for In Vitro Toxicity Testing, by Region, Through 2023
Research Institutes/Organizations that Offer In Vitro Testing and Other Services
Instruments Used in In Vitro Toxicology Testing, 2017
Global Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint and Test, Through 2023
ADME In Vitro Toxicity Products
Global Market for ADME Testing Technologies, by Region, Through 2023
Global Market for Skin Irritation, Corrosion and Sensitization Testing Technologies, by Region, Through 2023
Global Market for Pharmaceutical and Biotechnology End-User Industry, by Region, Through 2023
Global Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
List of Figures:
Global Market for In Vitro Toxicity Testing, by Region, 2017-2023
Timeline of Animal Testing Ban in India
Regulations timeline for Cosmetic Testing on Animals
Comparison Between In Vivo and In Vitro Toxicity
Merck KGaA Toxicology Services
Global Per Capita Healthcare Expenditure, by Country, 2016
In Vitro Toolbox for Acute Inhalation Toxicity
Features of ToxiScreen
Drug Discovery Process
Use of Metabolomics Toxicology
Types of Toxicity Studies
Features of Thiol Tracker Violet
Features of Trace Finder Software
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