Bifunctional Chelate Market Status, Key Players, Future Forecast and Growth Opportunity to 2025

Bifunctional Chelate is a type of bonding of ions and molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central atom. These ligands are called chelants, chelators, chelating agents, or sequestering agents. They are usually organic compounds.

Chelation is useful in applications such as providing nutritional supplements, in chelation therapy to remove toxic metals from the body, as contrast agents in MRI scanning, in manufacturing using homogeneous catalysts, in chemical water treatment to assist in the removal of metals, and in fertilizers.This report researches the worldwide Bifunctional Chelate market size (value, capacity, production and consumption) in key regions like North America, Europe, Asia Pacific (China, Japan) and other regions.This study categorizes the global Bifunctional Chelate breakdown data by manufacturers, region, type and application, also analyzes the market status, market share, growth rate, future trends, market drivers, opportunities and challenges, risks and entry barriers, sales channels, distrib The chelate effect is the enhanced affinity of chelating ligands for a metal ion compared to the affinity of a collection of similar nonchelating (monodentate) ligands for the same metal.

Request Sample Copy of Bifunctional Chelate Market Report:

https://www.marketreportsworld.com/enquiry/request-sample/12192118

The thermodynamic principles underpinning the chelate effect are illustrated by the contrasting affinities of copper(II) for ethylenediamine (en) vs. methylamine.

Cu2+ + en ⇌ [Cu(en)]2+

Cu2+ + 2 MeNH2 ⇌ [Cu(MeNH2)2]2+

In (1) the ethylenediamine forms a chelate complex with the copper ion. Chelation results in the formation of a five-membered CuC2N2 ring. In (2) the bidentate ligand is replaced by two monodentate methylamine ligands of approximately the same donor power, indicating that the Cu–N bonds are approximately the same in the two reactions.

The thermodynamic approach to describing the chelate effect considers the equilibrium constant for the reaction: the larger the equilibrium constant, the higher the concentration of the complex.

[Cu(en)] = β11[Cu][en]

[Cu(MeNH2)2] = β12[Cu][MeNH2]2

Electrical charges have been omitted for simplicity of notation. The square brackets indicate concentration, and the subscripts to the stability constants, β, indicate the stoichiometry of the complex. When the analytical concentration of methylamine is twice that of ethylenediamine and the concentration of copper is the same in both reactions, the concentration [Cu(en)] is much higher than the concentration [Cu(MeNH2)2] because β11 ≫ β12.

An equilibrium constant, K, is related to the standard Gibbs free energy, {displaystyle Delta G^{ominus }} Delta G^{ominus } by

{displaystyle Delta G^{ominus }=-RTln K=Delta H^{ominus }-TDelta S^{ominus }} {displaystyle Delta G^{ominus }=-RTln K=Delta H^{ominus }-TDelta S^{ominus }}

where R is the gas constant and T is the temperature in kelvins. {displaystyle Delta H^{ominus }} {displaystyle Delta H^{ominus }} is the standard enthalpy change of the reaction and {displaystyle Delta S^{ominus }} {displaystyle Delta S^{ominus }} is the standard entropy change.

Since the enthalpy should be approximately the same for the two reactions, the difference between the two stability constants is due to the effects of entropy. In equation (1) there are two particles on the left and one on the right, whereas in equation (2) there are three particles on the left and one on the right. This difference means that less entropy of disorder is lost when the chelate complex is formed with bidentate ligand than when the complex with monodentate ligands is formed. This is one of the factors contributing to the entropy difference. Other factors include solvation changes and ring formation. Some experimental data to illustrate the effect are shown in the following table.utors and Porter's Five Forces Analysis.

Global Bifunctional Chelate market size will increase to Million US$ by 2025, from Million US$ in 2017, at a CAGR of during the forecast period. In this study, 2017 has been considered as the base year and 2018 to 2025 as the forecast period to estimate the market size for Bifunctional Chelate.

For More Enquiry Please Ask Our Experts At: https://www.marketreportsworld.com/enquiry/pre-order-enquiry/12192118

This report focuses on the top manufacturers' Bifunctional Chelate capacity, production, value, price and market share of Bifunctional Chelate in global market. The following manufacturers are covered in this report:

BioPAL

AMERICAN ELEMENTS

BV Cyclotron

Bifunctional Chelate Breakdown Data by Type

Inorganic Chelate

Organic Chelate

Bifunctional Chelate Breakdown Data by Application

Chemical Industry

Laboratory

Others

Bifunctional Chelate Production Breakdown Data by Region

United States

Europe

China

Japan

Other Regions

Bifunctional Chelate Consumption Breakdown Data by Region

North America

United States

Canada

Mexico

Asia-Pacific

China

India

Japan

South Korea

Australia

Indonesia

Malaysia

Philippines

Thailand

Vietnam

Europe

Germany

France

UK

Italy

Russia

Rest of Europe

Central & South America

Brazil

Rest of South America

Middle East & Africa

GCC Countries

Turkey

Egypt

South Africa

Rest of Middle East & Africa

The study objectives are:

To analyze and research the global Bifunctional Chelate capacity, production, value, consumption, status and forecast;

To focus on the key Bifunctional Chelate manufacturers and study the capacity, production, value, market share and development plans in next few years.

To focuses on the global key manufacturers, to define, describe and analyze the market competition landscape, SWOT analysis.

To define, describe and forecast the market by type, application and region.

To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.

To identify significant trends and factors driving or inhibiting the market growth.

To analyze the opportunities in the market for stakeholders by identifying the high growth segments.

To strategically analyze each submarket with respect to individual growth trend and their contribution to the market.

To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market.

To strategically profile the key players and comprehensively analyze their growth strategies.

Applications:

Nutritional supplements

In the 1960s, scientists developed the concept of chelating a metal ion prior to feeding the element to the animal. They believed that this would create a neutral compound, protecting the mineral from being complexed with insoluble salts within the stomach, which would render the metal unavailable for absorption. Amino acids, being effective metal binders, were chosen as the prospective ligands, and research was conducted on the metal–amino acid combinations. The research supported that the metal–amino acid chelates were able to enhance mineral absorption.

During this period, synthetic chelates such as ethylenediaminetetraacetic acid (EDTA) were being developed. These applied the same concept of chelation and did create chelated compounds; but these synthetics were too stable and not nutritionally viable. If the mineral was taken from the EDTA ligand, the ligand could not be used by the body and would be expelled. During the expulsion process the EDTA ligand randomly chelated and stripped another mineral from the body.

According to the Association of American Feed Control Officials (AAFCO), a metal–amino acid chelate is defined as the product resulting from the reaction of metal ions from a soluble metal salt with amino acids, with a mole ratio in the range of 1–3 (preferably 2) moles of amino acids for one mole of metal.[citation needed] The average weight of the hydrolyzed amino acids must be approximately 150 and the resulting molecular weight of the chelate must not exceed 800 Da.[citation needed]

Since the early development of these compounds, much more research has been conducted, and has been applied to human nutrition products in a similar manner to the animal nutrition experiments that pioneered the technology. Ferrous bis-glycinate is an example of one of these compounds that has been developed for human nutrition.

Dental and oral application

First-generation dentin adhesives were first designed and produced in the 1950s. These systems were based on a co-monomer chelate with calcium on the surface of the tooth and generated very weak water resistance chemical bonding (2–3 MPa).[16]

Heavy-metal detoxification

Main article: Chelation therapy

Chelation therapy is used as antidotes for poisoning by mercury, arsenic, and lead. Chelating agents convert these metal ions into a chemically and biochemically inert form that can be excreted. Chelation using calcium disodium EDTA has been approved by the U.S. Food and Drug Administration (FDA) for serious cases of lead poisoning. It is not approved for treating "heavy metal toxicity".

Although beneficial in cases of serious lead poisoning, use of disodium EDTA (edetate disodium) instead of calcium disodium EDTA has resulted in fatalities due to hypocalcemia.[18] Disodium EDTA is not approved by the FDA for any use,[17] and all FDA-approved chelation therapy products require a prescription.[19]

Pharmaceuticals

Chelate complexes of gadolinium are often used as contrast agents in MRI scans, although iron particle and manganese chelate complexes have also been explored. Bifunctional chelate complexes of zirconium, gallium, fluorine, copper, yttrium, bromine, or iodine are often used for conjugation to monoclonal antibodies for use in antibody-based PET imaging. These chelate complexes often employ the usage of hexadentate ligands such as desferrioxamine B (DFO), according to Meijs et al., and the gadolinium complexes often employ the usage of octadentate ligands such as DTPA, according to Desreux et al. Auranofin, a chelate complex of gold, is used in the treatment of rheumatoid arthritis, and penicillamine, which forms chelate complexes of copper, is used in the treatment of Wilson's disease and cystinuria, as well as refractory rheumatoid arthritis.

Other medical applications

Chelation in the intestinal tract is a cause of numerous interactions between drugs and metal ions (also known as "minerals" in nutrition). As examples, antibiotic drugs of the tetracycline and quinolone families are chelators of Fe2+, Ca2+, and Mg2+ ions.

EDTA, which binds to calcium, is used to alleviate the hypercalcimia that often results from band keratopathy. The calcium may then be removed from the cornea, allowing for some increase in clarity of vision for the patient.

In this study, the years considered to estimate the market size of Bifunctional Chelate:

History Year: 2013-2017

Base Year: 2017

Estimated Year: 2018

Forecast Year 2018 to 2025

Place a Purchase Order For Bifunctional Chelate Market At: https://www.marketreportsworld.com/purchase/12192118

ABOUT Us:

Market is changing rapidly with the ongoing expansion of the industry. Advancement in the technology has provided today’s businesses with multifaceted advantages resulting in daily economic shifts. Thus, it is very important for a company to comprehend the patterns of the market movements in order to strategize better. An efficient strategy offers the companies with a head start in planning and an edge over the competitors. Market Reports World is the credible source for gaining the market reports that will provide you with the lead your business needs.

Contact Us:
Mr.Ajay More
Phone : +1 408 520 9750
Email : sales@marketreportsworld.com

Market is changing rapidly with the ongoing expansion of the industry. Advancement in the technology has provided today’s businesses with multifaceted advantages resulting in daily economic shifts. Thus, it is very important for a company to comprehend the patterns of the market movements in order to strategize better. An efficient strategy offers the companies with a head start in planning and an edge over the competitors. Market Reports World is the credible source for gaining the market reports that will provide you with the lead your business needs.

Market Reports World

3rd Floor, Silver Spring, Sahyadri farms,

Opp Prabhavee Tech Park,

Baner - Mhalunge Road, Baner, Pune 411045.

This release was published on openPR.