openPR Logo
Press release

New MRI reporter probes draw a more comprehensive picture on molecular imaging applications

09-01-2010 03:11 PM CET | Health & Medicine

Press release from: EIBIR gGmbH

European Network for Cell Imaging and Tracking Expertise

European Network for Cell Imaging and Tracking Expertise

Vienna, September 1, 2010 --- An international team with a broad variety of expertise in the field of cell imaging has developed novel MR imaging reporter probes, after a 2-years successful research work within the EU-funded project entitled “European Network for Cell Imaging and Tracking Expertise” (ENCITE).

To exploit the superb spatial and temporal resolution of MRI in Molecular Imaging applications, it is necessary to improve the sensitivity and specificity of the currently available probes:

1. Sensitivity. A new high relaxivity tetrameric Gd-based agent has been shown to provide an impressive seven-fold sensitivity enhancement in respect to the commercial agents maintaining an analogous safety profile.
2. Specificity. An enzyme responsive Gd probe has been synthesized and tested. It reports about the citivity of beta-galactosidase, an enzyme largely used by biologists as reporter of gene expression.

Important advances have been made in the field of the new family of MRI-CEST agents (CEST= Chemical Exchange Saturation Transfer). These MRI probes have great advantages with respect to the classical relaxation agents. Being frequency-encoding systems, it is possible to visualize (using different colours) more probes in the same image as every CEST agent is responsive only to a specific irradiation frequency. In the project, a paramagnetic complex, present as a pair of nmr-detectable isomers, has been selected for its high sensitivity and its ability to act as pH sensor. Mapping pH appears to be an important task to get new functional information from MR images in the presence of relevant pathologies. Moreover, upon changing the Lanthanide ion in the complex, systems able to visualize different cell types have been prepared and successfully tested.

For more information on the project findings please visit:

The consortium of the project has the ambitious long-term mission to develop and test new MR and optical imaging methods and biomarkers to draw a more comprehensive picture of cell fate and the reaction of the immune system. In the end cell therapy shall be improved for the benefit of the European patient.

ENCITE is a four year project co-funded by the European Commission under the 7th Framework Programme and co-ordinated by the European Institute for Biomedical Imaging Research (EIBIR). It started in June 2008 and consists of 29 international scientific partners from ten countries with outstanding expertise in cell imaging and tracking.

Prof. Silvio Aime, Eva Haas
Phone: 0043-1-533-4064-29 begin_of_the_skype_highlighting              0043-1-533-4064-29      end_of_the_skype_highlighting begin_of_the_skype_highlighting              0043-1-533-4064-29      end_of_the_skype_highlighting begin_of_the_skype_highlighting              0043-1-533-4064-29      end_of_the_skype_highlighting begin_of_the_skype_highlighting              0043-1-533-4064-29      end_of_the_skype_highlighting


The European Institute for Biomedical Imaging Research (EIBIR) is a non-profit limited liability company dedicated to the co-ordination of research. The network has the aim of co-ordinating and supporting the development of biomedical imaging technologies and the dissemination of knowledge with the ultimate goal of improving diagnosis, treatment and prevention of disease. The platform supports networking activities in research and is key to spreading good practice, promoting common initiatives and interoperability in the field of biomedical imaging research. This will generate critical mass and help coordinate research into new instrumentation, new methods, concepts and technologies.

European Institute for Biomedical Imaging Research
Eva Haas
Neutorgasse 9
1010 Vienna, Austria
Phone: 0043-1-533-4064-29
Fax: 0043-1-535-7041

This release was published on openPR.

Permanent link to this press release:

Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release New MRI reporter probes draw a more comprehensive picture on molecular imaging applications here

News-ID: 143358 • Views: 783

More Releases from EIBIR gGmbH

ENCITE Final Public Workshop
The European Network for Cell Imaging and Tracking Expertise invites you to the final public event. Monday, 5 November 2012, 8:00 – 18:00 Leiden University Medical Center, Leiden/NL Programme available at: No registration fee required! For pre-registration, please send an email to: All involved scientists in ENCITE are very pleased to announce that the end of the highly successful ENCITE project will be marked by a closing event presenting new technologies and methods
ENCITE Workshop on Molecular Imaging in Skeletal Tissue Regeneration
Date: 25—27 October 2011 Venue: Tel Aviv University/IL Students and scientists involved in biomedical imaging, tissue regeneration and stem cell therapies with focus on skeletal disorders are welcome. Both ENCITE partners, the Tel Aviv University and the Hebrew University of Jerusalem, are pleased to organise this workshop. Further information on other ENCITE events can be found online at ENCITE project The European Institute for Biomedical Imaging Research (EIBIR) was established by the European Society
ENCITE Mini-categorical Course on Molecular Imaging at ESMRMB 2011
Date: 6—8 October 2011, 08:00–09:00 Venue: Leipzig/DE Meet ENCITE experts at ESMRMB 2011! New tools, MR contrast agents and sequences as well as in vivo / in vitro spectroscopy work and cell tracking in a pre-clinical setting will be presented. Experts from the Netherlands, the United Kingdom, Germany and Belgium will present new tools for optical imaging, MR contrast agents and MR sequences as well as news on in vitro and in vivo spectroscopy,
ENCITE Educational Course on Molecular MRI in Experimental Neuroscience
Date: 30 June — 2 July 2011 Venue: Max-Planck-Institute, Cologne/DE ENCITE is pleased to offer this course within the“Lectures on MR” programme of the European Society for Magnetic Resonance in Medicineand Biology (ESMRMB). Both partners Max-Planck-Institute/DE and University of Basel/CH are in charge of the scientific programme. Further information on more ENCITE events can be found online at ENCITE project The European Institute for Biomedical Imaging Research (EIBIR) was established by the European Society

All 5 Releases

More Releases for European

23rd European Nephrology Conference
23rd European Nephrology Conference is the world’s leading conference for Nephrology professionals to gather and contribute their research for developing the new techniques in the field of Nephrology. Nephrology Conferences offers over 30 sessions from different areas in the field of Nephrology in the form of Keynote, Plenary and workshop sessions including oral and poster presentations. Nephrology Conferences which is going to be held in global & ancient city Rome, Italy
27th European Cardiology Conference
With the successful completion of 20th European Cardiology Conference, the Cardiology Conferences in 2018 meet is proud to announce that its 3 day 27th European Cardiology Conference (Euro Cardiology 2018) will be held in Rome, Italy during October 22-24, 2018.The conference will be the world’s best platform for all the cardiologists, cardiac surgeons, medical practitioners, research scholars and clinical research organizations to encourage and explore the modern technologies in the
27th European Diabetes Congress
Rising awareness, new technologies and practical approaches within the field of diabetes and endocrine disorders in world’s leading diabetes Conferences One in eight ladies can develop a diabetes disorder throughout her lifespan. And, the amount of individuals affected by diabetes disorders continues to rise every year. However the larger drawback is that almost 60 minutes of those individuals are fully unaware of their condition as well as a way to heal
27th European Diabetes Congress
We would like to invite your team as a Speakers/Delegates. On behalf of Organizing Committee, we take this opportunity in extending a warm and cordial welcome to you to be part of “27th European Diabetes Congress”, held conjointly with multifarious scientific associations, eminent researchers and scholars from all around the globe during June 20-21, 2018 at Rome, Italy. It is an immense pleasure and privilege having you here with us
10-26-2017 | Health & Medicine
BIOCAD Enters European Market
The largest Russian biotechnology company BIOCAD plans to enter the European market with oncological and autoimmune medicines. So far, there are seven molecules in the European portfolio of BIOCAD. This are innovative and biosimilar products, which could be used in treatment of melanoma, breast, stomach, kidney and lung cancer, rheumatoid arthritis, psoriasis and multiple sclerosis. BIOCAD presents its latest developments at the CPhI exhibition in Frankfurt on October 24-26, 2017. The
20th European Cardiology Conference
Euro Cardiology 2017 invites all the cardiologists, Scientists, Professors, Research scholars, Industrial Professionals, Cardiac surgeons at 20th European Cardiology Conference is going to be held in Budapest, Hungary during October 16-18, 2017. With the support of Euro Cardiology 2016 Organizing Committee Members, the CME accredited 20th European Cardiology Conference is scheduled to be held in Budapest, Hungary during October 16-18, 2017. Cardiology Conferences will lay a platform for world-class professors, cardiologists