Controlled-Release Drug Delivery Technology Market: Regulations and Competitive Landscape Outlook to 2027

Specific focus on the quality-by-design (QbD) approaches for the robust design of dosage forms is expected to change the future landscape of controlled-release drug delivery technologies. While conventional hydrophilic matrix based technologies such as Accuform are being used in the market for several years, recent advancements in the development of oral drug delivery systems such as gastro-retentive drug delivery for controlled release, buoyant systems, mucoadhesive systems for regulated release of anti-viral medications etc. would increase the penetration of controlled-release drug delivery technologies in the global pharmaceuticals market.

Acuform polymer-based patented technology is widely being used in a number of controlled-release formulations such as NUCYNTA ER, Gralise (Depomed Inc.), Janumet XR (Merck), Glumetza (Salix Pharmaceuticals) etc. Wurster coating technology is being used in the drug coating for controlled release of drug since 1976. Corplex transdermal technology has largely been commercialized in P&G’s Crest product line. Plenty of new controlled-release technologies are in phase to be commercialized in next few years. For instance, MicroCor PTH using MicroCor transdermal technology is being evaluated in phase IIa.

OROS technology which delivers drug in controlled manneris being used in more than 17 commercially available drugs. In case of oral controlled drug delivery, elderly persons and pediatrics constitute the large proportion of consumers for controlled-release drugs due to increase adherence to dosage regime. Some of the commercially available medications using controlled-release drug delivery technology include Prozac (polymer matrix based system), Avinza (polymer coating), Capoten (enzyme activated system), GLUCOPHAGE XR (polymer matrix based system), Alza (osmotically activated system) etc.

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Controlled-Release Drug Delivery Technology Market: Drivers and Restraints

The global market for controlled-release drug delivery technology is driven by increasing the need for pediatric controlled release dosage forms, high acceptance of CR dosage forms due to once-a-daily dosing nature, etc. However, some of the major factors restraining the global market for controlled-release drug delivery technology are fewer excipients are deemed acceptable for pediatric use, the requirement of a high dose of API, promising development of CR dosage forms that impart abuse resistance, a higher price of controlled-release systems compared with traditional pharmaceutical formulations, etc. Moreover, some of the biopharmaceutical challenges for development of controlled-release drug delivery systems such as establishing desired release profiles for new chemical entities, risk management of dose dumping, selection of biocompatible and biodegradable materials with desired controlled-release properties, etc.

Controlled-Release Drug Delivery Technology Market: Segmentation

The global controlled-release drug delivery technology market has been segmented on the basis of technology, release mechanism, application, and geography.

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Based on technology, the global controlled-release drug delivery technology market is divided into following:

Wurster technique (drug coating)

Coacervation

Micro Encapsulation

Implants

Transdermal

Targeted Delivery

Microelectromechanical Technology

Others (Liposomes)

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