Healthcare News: CAR T Cell Therapy Industry by Applications 2018 Top Players are Novartis, Kite Pharma, Juno Therapeutics, Pfizer, Celgene Corporation, bluebird bio, Atara Biotherapeutics, Bellicum Pharmaceuticals
The CAR T therapy uses the patient’s own immune system as well as develops it to target the tumor cells and execute them. This therapy is depending on the re-engineering of T-cells to make them recognize cancer cells and target such cells when they generally fail to do so. This therapy has proven very operative in patients with blood cancer who have already gone through alternative therapies such as chemotherapy.
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The Choice of the Target Antigen to Define the Type of Therapy
The CD19 antigen present on the surface of the B cell has proven to be the highly effective CAR T cell therapy with approved treatment for leukemia and lymphoma where B cells have become carcinogenic. Currently, Kymriah by Novartis and Yescarta (manufactured and distributed by Kite Pharma, a subsidiary of a US-based company, Gilead Sciences) are only approved products for B Cell Acute Lymphoblastic Leukemia (ALL) and Large B-Cell lymphoma respectively. The key players in this sector are evolving new CAR-T therapies targeting different antigens for solid tumor including L1CAM, MUC16 and for blood cancers including CD123, CD22, BCMA among others.
CAR T Cell Therapy Market by Application
• Acute Lymphoblastic Leukemia
• Diffuse Large B-Cell Lymphoma
• Follicular Lymphoma
• Chronic Lymphocytic Leukemia
• Multiple Myeloma
• Kite Pharm,
• Juno Therapeutics
• Celgene Corporation
• bluebird bio
• Atara Biotherapeutics
• Bellicum Pharmaceuticals
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In terms of geography, North America region is estimated to dominate the global CAR T Cell Therapy Market. Increasing research and developments programs as well as ongoing regulatory approvals are factors attributed for the augmented market growth of CAR T cell therapy.
For instance, Kymriah (a Novartis product) has cleared the USFDA approval in August 2017 for the treatment of patients suffering from acute lymphoblastic leukemia. Moreover, key players such as Novartis and Kite are the first to reach US market and are expected to focus on expansion via the number of academic centers that can provide appropriate cancer treatments in 2018.
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