Tamoxifen Market - Size, Share, Outlook, and Opportunity Analysis 2018-2026

Tamoxifen is a type of selective estrogen receptor modulator (SERM) indicated for the treatment of women with high risk of breast cancer. Since its approval in 1998, tamoxifen has been used to treat millions of patients diagnosed with hormone receptor positive, early stage of breast cancer after surgery to reduce the risk of recurrence. It is the first choice for treatment of premenopausal women. Tamoxifen is the generic name for Nolvadex. Tamoxifen has off-label usage for the treatment of infertility, gynecomastia, retroperitoneal fibrosis, and idiopathic sclerosing mesenteritis.

Tamoxifen is a type of selective estrogen receptor modulator. The main pharmacologic action of Tamoxifen is to block the growth-promoting effects of estrogens on breast cancer. In bone cells, selective estrogen modulators interact with receptors the way estrogen does and strengthens bones. Tamoxifen is available in various forms such as powder, capsules, oral solution, and tablets.

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Tamoxifen Market Dynamics

Being a generic molecule, the growth of the market has slowed down with increased competition. However, emergence of combination therapies and additional therapeutic indications for tamoxifen is expected to fuel the market growth. For instance, 2018 Novartis received breakthrough therapy designation for Kisqali by FDA in Phase 3. Designation was based on the successful phase 3 MONALEESA-7 trials, which demonstrated significant prolonged-free survival (PFS) of Kisqali + tamoxifen (or an aromatase inhibitor). Moreover, increasing number of government and non-government organizations are investing to discover additional therapeutic applications of tamoxifen, which in turn, is expected to boost market growth. For instance, In 2017 Duchenne UK, E-Rare, Duchenne Parent Project, and Monaco Association jointly contributed US$ 766,338 for a clinical trial, which aims to study the effects of tamoxifen in treating duchenne muscular dystrophy.

However, 2017, survey from European Cancer Congress discovered that the cost of tamoxifen increased 10 times during the period 2011 - 2016, despite being generic. The research found that the cost of the drug was 20 times the price in India. Such disparity in prices, with no adequate reimbursement deters acceptance for the drug. Furthermore, adverse effects of tamoxifen therapy such as anxiety, vaginal discharge, and painful urination, is expected to hamper the tamoxifen market growth.

Furthermore, increasing prevalence of breast cancer among women, both in developed and emerging economies is a major factor driving growth of the tamoxifen market. According to 2012, World Cancer Research Fund International report, around 1.7 million new breast cancer cases were diagnosed in 2012, which reflected an increase by over 20% from 2008.

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