Thebaine Market - Size, Share, Outlook, and Forecast till 2026

Worldwide Market Reports added Latest Research Report titled “Global Thebaine Market by Manufacturers, Regions, Product Type and Application, Forecast up to 2026” to its Large Report database.

Thebaine also called as codeine methyl enol ether is an opiate alkaloid having stimulatory effects, which causes convulsions similar to strychnine poisoning. It is a minor constituent of opium, which is chemically identical to both morphine and codeine. Thebaine is extracted from Papaver bracteatum (Iranian poppy). It can be converted into a variety of compounds, including oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine, etorphine, and butorphanol. The synthetic enantiomer (+)-thebaine does show analgesic effects apparently mediated through opioid receptors, unlike the inactive natural enantiomer (−)-thebaine. This alkaloid is biosynthetically related to salutaridine, oripavine, morphine, and reticuline.

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Increasing adoption of thebaine among pharmaceutical companies is major factor driving growth of the thebaine market, as it is essential precursor for synthesis of widely-prescribed pharmaceuticals such as analgesics oxycodone and hydrocodone and the addiction treatments buprenorphine and naltrexone. However, over use of thebaine can lead to serious health issues, which is restraining growth of the thebaine market. According to the Centers for Disease Control and Prevention (CDC), opioid abuse is a serious public health issue, with drug overdoses identified as the leading cause of injury death in the U.S. The number of opioid overdose deaths has quadrupled since 1999, and six out of every ten overdose deaths are caused due to opioid. Ninety-one Americans die annually from an opioid overdose.

Key Developments in Thebaine Market

Manufacturers are engaged in developing novel drugs using thebaine in order meet increasing demand form pharmaceutical and biotechnology sector. Furthermore, various research organizations are focused on production of opiate compounds from plants, which is further driving growth of the thebaine market. For instance, in May 2018, a University of Calgary-led research team discovered the gene for naturally and efficiently producing a compound in opium poppy plants, which is used to make opiate pain-killing drugs. The team found the gene that encodes a previously unknown protein, an enzyme called thebaine synthase, which plays a vital role in catalyzing the production of thebaine in opium poppies, which can be used as inexpensive yeast-based system for manufacturing opiates.

Moreover, in June 2018, Epimeron Inc., a Calgary-based biotechnology company announced the isolation of a novel gene from the opium poppy (Papaver somniferum). The gene encodes the enzyme thebaine synthase, which had previously been hypothesized for various applications. Key players operating in thebaine market include Mallinckrodtm Pharmaceuticals, Noramco, Alcaliber, Tasmanian Alkaloids, TPI, Cepia-Sanofi, Taj Pharmaceuticals, API Labs, Faran Shimi Pharmaceuticals, Gansu Alkaloids, and Hwells.

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