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Global CAR T Cell Therapy Market Opportunity and Clinical Pipeline Insight 2024

05-24-2018 11:53 AM CET | Health & Medicine

Press release from: Kuick Resarch

Global CAR T Cell Therapy Market Opportunity and Clinical

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For Report Sample Contact: neeraj@kuickresearch.com

Table of Contents

1. Chimeric Antigen Receptor (CAR) T Cell Therapy - Next Era in Immuno Oncology
1.1 Overview
1.2 History and Development of CAR-T Technology

2. Development of Chimeric Antigen Receptor (CAR) T-Cell Design
2.1 Structure of CAR-T Cell
2.2 1st Generation Chimeric Antigen Receptor
2.3 2nd and 3nd Generation CAR-T Cell

3. Chimeric Antigen Receptor Design Standards
3.1 CAR Modified T-Cells: Targeting
3.2 CAR Modified T-Cell: Signaling

4. CAR T-Cell Therapies Delivery Pipeline and Mechanism of Action
4.1 Process of CAR T-Cell Therapy
4.2 Mechanism of Action

5. Approaches to Improve the Efficacy of CAR-T Cell Therapy
5.1 Introduction
5.2 Targeting the Tumor Stroma with CAR-T Cells
5.3 Targeting the Cytokine Networks
5.4 Combination Strategies for CAR-T Cells
5.5 Targeting the Immune Checkpoints

6. Global CAR T-Cell Therapy - Clinical Trials for Cancer Treatment
6.1 Acute Lymphoblastic Leukemia
6.2 Multiple Myeloma
6.3 Brain Tumors
6.4 Lymphoma
6.5 Solid Tumors

7. CAR-T Cell Therapy Market Analysis by Product
7.1 Kymriah by Novartis
7.2 Yescarta by Gilead

8. Recent Advances Impacting the CAR - T Cell Market

9. Sales Analyis of CAR - T Cell Therapy

10. Cost Analysis and Market Potential of CAR - T Cell Therapy
10.1 Manufacturing Cost Analysis of CAR-T Cell Therapy Products
10.2 Price Analysis of CAR-T Cell Therapy
10.3 Global - Estimated Potential Customer Base and Revenue Analysis

11. Global CAR T-Cell Therapy Market Overview
11.1 Market Share of Cancer Immunotherapy by Technique
11.2 CAR-T Cell Therapy Market Value

12. Global CAR-T Cell Therapy Market Dynamics
12.1 Favorable Parameters
12.2 Challenges

13. Global CAR-T Cell Therapy Market Future Outlook

14. Global CAR-T Cell Therapies Clinical Pipeline by Company, Indication and Phase
14.1 Research
14.2 Preclinical
14.3 Clinical
14.4 Phase-I
14.5 Phase-I/II
14.6 Phase-II

15. Marketed CAR-T Cell Therapies Clinical Insight
15.1 Axicabtagene Ciloleucel (Yescarta)
15.2 Tisagenlecleucel (Kymriah)

16. Competitive Landscape
16.1 Autolus
16.2 Bellicum
16.3 Bluebird
16.4 Celgene
16.5 Cellectis
16.6 Celyad
16.7 Eureka Therapeutics
16.8 Fortress Biotech
16.9 Immune Therapeutics
16.10 Juno Therapeutics
16.11 Kite Pharma
16.12 Novartis
16.13 Sorrento therapeutics
16.14 TILT Biotherapeutics
16.15 Ziopharm

Figure 1-1: Historical Development of CAR-T Cell Therapy
Figure 2-1: Structure of Chimeric Antigen Receptor
Figure 2-2: First Generation Chimeric Antigen Receptor
Figure 2-3: Second Generation Chimeric Antigen Receptor
Figure 2-4: Third Generation Chimeric Antigen Receptor
Figure 3-1: Targeting Mechanism of Chimeric Antigen Receptor T-Cell
Figure 3-2: Signalling Mechanism of Chimeric Antigen Receptor T-Cell
Figure 4-1: Delivery Pipeline of CAR-T Cell Therapy Process
Figure 4-2: CAR T Cell Therapy Mechanism of Action
Figure 5-1: Strategies to Improve CAR T Cell Therapy
Figure 6-1: CAR T Cell Therapy in Brain Tumors
Figure 6-2: Chimeric Antigen Receptor Therapy in Lymphoma
Figure 6-3: Target of Cancer Cell by Chimeric Antigen Receptor
Figure 7-1: Kymriah - Product Overview
Figure 7-2: Yescarta - Product Overview
Figure 9-1: US - Total Lymphoblastic Leukemia Patients and Kymriah Eligible Patients(%), 2018
Figure 9-2: Global - Kymriah Sales (US$ Million), 2018
Figure 10-1: Adoptive T-Cell Therapy Clinical Trials to Investigate the Efficacy and Safety (%), 2018
Figure 10-2: CAR-T cell - Estimated Manufacturing Cost (US$), 2018
Figure 10-3: Price Analysis - CAR-T Cell Therapy (US$/Patient), 2018
Figure 10-4: US - Distribution of CMS and out of Pocket Cost in CAR T Cell (US$/patient), 2018
Figure 10-5: Yescarta - Complete Cost Analyis for CAR T-Cell Treatment (US$), 2018
Figure 10-6: US - Incidence of Acute Lyphocytic Leukemia (‘000’), 2018
Figure 10-7: US - Estimated Patient Base for CAR T cell Therapy (Number), 2018
Figure 10-8: US - Current Market Revenue v/s Total Potential Revenue of CAR T cell Therapy (US$), 2018
Figure 10-9: Europe - Total Eligible Patients v/s Patients Receiving CART T Cell Treatment (Number), 2018
Figure 11-1: Cancer Immunotherapy - Market Size of CAR T Cell by Technique (%), 2018
Figure 12-1: Favorable Market Parameters of CAR T Cell Therapy
Figure 12-2: Challenges to Market Growth of CAR T Cell Therapy
Figure 13-1: Global - Cancer Immunotherapeutic Market Forecast (US$ Billion), 2018-2024
Figure 13-2: Future Potential Immuno-Oncology
Figure 13-3: Global - CAR T Cell Therapy Market Opportunity (US$ Million), 2018 -2024
Figure 14-1: Global - CAR-T Cell Therapies Clinical Pipeline by Phase (%), 2018 till 2024
Figure 14-2: Global - CAR-T Cell Therapies Clinical Pipeline by Phase (Number), 2018 till 2024
Figure 14-3: Global - Discontinued CAR-T Cell Therapies Clinical Pipeline by Phase (%),2018 till 2024
Figure 14-4: Global - Discontinued CAR-T Cell Therapies Clinical Pipeline by Phase (Number), 2018 till 2024






Table 3-1: Antigens which are targeted by Chimeric Antigen Receptor

Table 16-1: Clinical Pipelines of Products

Kuick Research is a market research and analytics company that provides targeted information for critical decisions at business, product and service levels. We are quick, predictive and known by the recommendations we have made in the past. Our result-oriented research methodology offers understanding of multiple issues in a short period of time and gives us the capability to keep you full with loads of practical ideas. By translating research answers into strategic insight and direction, we not only rate the success potential of your products and/or services, but also help you identify the opportunities for growth in new demographies and find ways to beat competition.

Neeraj Chawla
neeraj@kuickresearch.com
KuicK Research
L29 - L34, First Floor
Block L,Connaught Place
New Delhi-110001
+91-11-47067990

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