Press release
Global Gene Therapy Market Size, Technologies, Challenges and Forecast to 2022
This report provides the reader with:
Current Global Market Worth and Forecast with CAGR Through 2022
Sub-Market Worth by Therapeutic Area (Cancer, Rare Diseases, Cardiovascular, Neurological, Ocular) and Forecast with CAGR Through 2022
Sub-Market Worth by Geography (Americas, Europe, RoW) and Forecast with CAGR Through 2022
Sub-Market Worth by Technology (Gene Product, Service, Viral Vectors) and Forecast with CAGR Through 2022
Insight into gene therapy technologies, challenges associated with developing therapeutic genes and disadvantages of gene therapy.
Full outline of the gene therapy industry from the formative years through to products discovered during 1990 and 2017.
Detailed descriptions of commercialized products approved between 2003 and 2017 that include: Gendicine, Rexin-G, Oncorine, Neovasculgen, Glybera, Imlygic, Strimvelis, Zalmoxis, Kymriah, Yescarta and Luxturna.
Description of seven of the Phase III product candidates that include: Generx, Collategene, LentiGlobin, Lenti-D, VM-202, Invosa and GS-010.
Description of 21 Phase II product candidates that are set to have significant market share.
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Commercialization status of gene therapies in by geographic region
Evaluation of gene therapy pricing
Description of the firstever warranty offer by GSK for Strimvelis.
A detailed analysis of various types of viruses used as vectors.
Description of clinical applications of gene therapy and the various genetic and infectious diseases addressed by gene therapy.
Description of 77 companies that are directly and indirectly associated with gene therapy industry.
1.3 Key Questions Answered in this Report
What is the size of gene therapy market?
What is the CAGR and market size over the next five years?
What are the different sub-markets and their worth/CAGR over the next five years?
What is gene augmentation therapy?
What is suicide gene therapy?
How is ex vivo gene delivery different from in vivo gene delivery?
What are the types of gene therapies classified on the basis of targeted cell types?
What is the role of CRISPR technology in gene therapy?
What are the approved gene therapy products?
How many gene therapy product candidates have reached the Phase III stage?
How many Phase II gene therapy product candidates are there?
What is the commercialization status of gene therapies in E.U. member countries?
What are the prices of gene therapy products?
What are the reasons for this extortionate pricing of gene therapies?
Which company is offering warranty for its gene- therapy product?
What is the current strength of gene therapy industry?
Is it true that the real strength of gene therapy industry is based on the number of clinical trials?
What is the total number of ongoing clinical trials as of 2017?
What is the distribution of clinical trials by geography?
Which countries are associated with gene therapy clinical trials?
What are the major indications addressed by the clinical trials?
Which genes are transferred in these clinical trials?
How many Big Pharma are associated with the gene therapy industry?
What are non-viral and viral vectors?
What are the various features of viral vectors?
Which viral vectors are predominantly used in gene therapy clinical trials?
What are the major diseases addressed by therapeutic genes?
Where is the gene therapy market heading, and what opportunities and challenges will it face?
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Table of Content
1.0 Introduction
1.1 Executive Summary
1.2 About this Report
1.3 Key Questions Answered in this Report
2.0 Gene Therapy: The Basics
2.1 Gene Therapy Techniques
2.1.1 Gene Augmentation Therapy
2.1.2 Gene Inhibition Therapy
2.1.3 Suicide Gene Therapy
2.2 Gene Therapy Routes
2.2.1 Ex Vivo Gene Delivery Route
2.2.2 In vivo Gene Delivery Route
2.3 CRISPR: Latest Technology in Gene Therapy
2.4 Challenges Associated with Developing Gene Therapies
2.5 Disadvantages of Gene Therapy
2.5.1 Short-Lived Nature of Gene Therapy
2.5.2 Immune Response
2.5.3 Problems with Viral Vectors
2.5.4 Multigenic Disorders
2.5.5 Insertional Mutagenesis
2.6 Concept to Product Candidates and Products
3.0 Historic Overview of Gene Therapy
3.1 The Formative Years of Gene Therapy
3.2 The Productive Years of Gene Therapy
3.2.1 Gendicine
3.2.2 Oncorine
3.2.3 Rexin-G
3.2.4 Neovasculgen
3.2.5 Glybera
3.2.6 Imlygic
3.2.7 Strimvelis
3.2.8 Zalmoxis
4.0 Gene Therapy Phase III Product Candidates
4.1 CardioNovo (Generx)
4.2 Collategene
4.3 LentiGlobin
4.4 Lenti-D
4.5 VM-202
4.6 Invossa
4.7 GS010
4.8 ADA-Lentiviral Gene Therapy
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5.0 Gene Therapy Phase II Product Candidates
5.1 hF-IX gene/Hemophilia B
5.2 NaGlu gene/San Fillipo B Syndrome
5.3 StarGen/Stargardt disease
5.4 UshStat/Usher Syndrome Type 1B
5.5 Retinostat/Wet AMD
5.6 Lenti-D/Childhood Cerebral ALD
5.7 LentiGlobin/Beta Thalassemia
5.8 SB-728/HIV/AIDS
5.9 CERE-110/Alzheimer’s disease
5.10 AATD/Alpha-1 Antitrypsin deficiency
5.11 RS1 gene/X-linked juvenile Retinoschisis (XLRS)
5.12 SPK-CHM/Choroideremia
5.13 SPK-FIX/Hemophilia B
5.14 AMG0001/Primary Lymphedema
5.15 AMG0001/Ischemic heart disease
5.16 WASp /Wiskott-Aldrich syndrome
5.17 X-linked CGD
5.18 GSK2696273/ADA gene
5.19 VM106/Chronic Granulomatous Disease
5.20 VY-AADC01/Parkinson’s disease
6.0 Commercialization, Cost and Warranty of Gene Therapies
6.1 Reasons for the Extortionate Price
6.1.1 High Cost of Manufacturing
6.1.2 High Cost of Delivery
6.1.4 Lack of Competition
6.1.5 Curing the Impossible
6.2 Strategies to Make Gene Therapy Affordable
6.3 The Age of First-Ever Warranty for Gene Therapy
7.0 The Strength of Gene Therapy Industry
7.1 Development of Appropriate Gene Delivery Vehicles
7.2 CRISPR-Based Therapy
7.3 Early Clinical Gene Therapy Protocols
7.4 Worldwide Scenario of Gene Therapy Clinical Trials
7.4.1 Geographical Distribution of Gene Therapy Clinical Trials
7.4.2 Gene Therapy Clinical Trials by Country
7.4.3 Major Indications Addressed by Gene Therapy Clinical Trials
7.4.4 Gene Types Transferred
7.4.5 Status of Gene Therapy Clinical Trials
7.5 Big Pharma’s Bold Venturing into Gene Therapy
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