Press Releases from Pharma Proff (76 total)
Acquired Immunodeficiency Syndrome (AIDS) Related Cancer Therapeutics- Pipeline …
Acquired immunodeficiency syndrome (AIDS) related cancer include those types of cancer which occurs in patients suffering from AIDS.
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People with AIDS are reported to be highly suspected to the occurrence of lymphomas. According to the American Society of Clinical Oncology, Kaposi sarcoma is very common in patients with AIDS; whereas non-Hodgkin’s lymphoma is second most common in patients with AIDS.
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Adrenocortical Carcinoma Therapeutics - Pipeline Analysis 2018, Clinical Trials …
Adrenocortical carcinoma, also known as adrenal cortex carcinoma, is a rare form of cancer that occurs at the cortex layer of the adrenal gland. There are two adrenal glands present in the human body: one at the top of each kidney.
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Each adrenal gland is comprised of two distinct structures: the outer part of the adrenal glands (adrenal cortex) and the inner region (adrenal medulla). Some…
Cathepsin K Inhibitors Therapeutics Pipeline Analysis 2019
Cathepsin K is a protease enzyme which is coded by CTSK gene. The function associated with the gene involves bone remodelling and resorption. Cathepsin K is a member of peptidase C1 protein family and expressed mainly in osteoclasts.
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The protein has high specificity for kinins and has the capability to catabolize collagen, elastin, and gelatin. Cathepsin K is found to be over-expressed in cancer such…
Adenosine 5-Monophosphate Activated Protein Kinase (AMPK) Modulators Therapeutic …
Adenosine 5-monophosphate activated protein kinase (AMPK) plays an important role in regulation of homeostasis. Dysregulation of AMPK can result in many diseases which includes obesity and type 2 diabetes. Several studies have also suggested that AMPK are also associated with the development of neurological diseases and cancer.
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Despite of many advancements in the development of anti-cancer therapies, cancer is still one of the major causes of…
Aurora Kinase Inhibitor Therapeutics - Pipeline Analysis 2018, Clinical Trials & …
Aurora kinase are proteins that function as mitotic regulators and are aberrantly expressed in cancerous cells. Aurora kinase inhibitors target these aberrantly expressed regulators, provides genetic stability and prevents tumorigenesis.
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Several studies have demonstrated overexpression and amplification of aurora kinase in various haematological and solid cancers. Aurora kinase inhibitors when combined with other anti-cancer agents gives more positive results in variety of cancers. Better evaluation of…
Angiopoietin (ANG) Inhibitors Therapeutics - Pipeline Analysis 2019
Angiopoietin (ANG) receptor plays a crucial role in regulation of vascular permeability and pathological vascular remodelling during tumour angiogenesis, metastasis and inflammation. Thus, it has emerged as a new clinical approach for the development of therapeutics which treat cancer and ophthalmological diseases.
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The exclusive function of these receptors in vascular stabilization also makes it an attractive target in organ transplantation, sepsis, vascular complications of diabetes…
Spleen Tyrosine Kinase (Syk) Inhibitor Therapeutics-Pipeline Analysis 2018
Spleen tyrosine kinase (Syk) is a protein that belongs to the family of tyrosine kinases with an ability to initiate the inflammatory responses, by connecting immune cell receptors to intracellular signaling pathways. Therefore, Syk is an attractive target for improving the symptoms related to acute and chronic inflammation. In addition, the role of protein is recognized as a promoter in various types of cancers ranging from leukemia to retinoblastoma.
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Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors Therapeutics- Pipeline Anal …
Glycogen synthase kinase 3 beta (GSK-3β) is an attractive target for the treatment of psychiatric disorders and neurodegenerative diseases. Many GSK-3β inhibitors have been developed for the treatment of different central nervous system disorders. But, for an effective therapy, high IC50 values should be avoided and ATP-competition should be reduced during enzyme-compound binding. Studies suggested that ATP non-competitive GSK-3 inhibitors such covalent inhibitors and allosteric modulators are emerging as a…
Hepatocyte Growth Factor (HGF) Inhibitor Therapeutics - Pipeline Analysis 2019 | …
Hepatocyte growth factor (HGF) is secreted by human pancreatic stellate cells and present predominantly on cancer cells. Thus, HGF inhibitors has emerged as an effective therapy in preventing local tumor growth. Also, studies have demonstrated that HGF inhibitors are significantly more effective than Gemcitabine in inhibiting tumor angiogenesis and metastasis.
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Studies have demonstrated that the HGF inhibitor can be a novel therapeutics that can be developed…
Interleukin 8 Inhibitors Therapeutics - Pipeline Analysis 2019 Designations, Col …
Interleukin 8 is a chemokine produced by various immune cells. They promote angiogenesis, proliferation and development of cancerous cells. The other diseases which are associated with interleukin 8 are depression, schizophrenia, bipolar disorder, migraine, Alzheimer’s disease, colitis, rheumatoid arthritis, multiple sclerosis, asthma, allergic rhinitis, psoriasis, eczema and others.
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Interleukin 8 inhibitors therapies have shown improvements as anti-CXCL8 signalling inhibitors for the treatment of various diseases, including…
Mitogen-Activated Protein Kinase (MAPK) Inhibitors Therapeutics - Pipeline Analy …
Mitogen-activated protein kinase (MAPK) are ubiquitous regulators of many cellular functions including cell proliferation, cellular growth, inflammatory responses to stress signals and cell differentiation. MAPK pathway, involves three main kinases, Raf, MEK and ERK, has emerged as a novel target for the development of new cancer therapies with reduced side-effects.
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MAPK inhibitors are being developed as small molecules, for the treatment of various types of cancer.…
MDM2 Protein Inhibitors Therapeutics, Clinical Trials & Results, Pipeline Analys …
MDM2 protein are powerful oncogene which is overexpressed in various cancers, including breast cancer and sarcoma. There are many small molecule drug candidates that are being developed as MDM2 protein inhibitors as monotherapy or combination therapy for the treatment of various cancers. Combination therapies are more effective than monotherapy in certain cases. The therapeutic strategies aim at blocking MDM2 expression, blocking the physical interaction between MDM2 and p53, modulating the…
Interleukin Receptor Modulators Therapeutics - Pipeline Analysis 2019
Interleukin receptors are a group of cytokine receptors that are expressed by leukocytes. Interleukin receptors play an important role in the functioning of the immune system. However, with complete knowledge of their role in pathogenesis of different diseases from allergic reactions to autoimmune disorders and even cancer makes these interleukin receptors an attractive target among different available treatment modalities.
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Immune-modulatory role of interleukins as well…
Endothelin Antagonists Therapeutics - Pipeline Analysis 2019
Endothelin antagonists are drug candidates that acts against endothelin receptors and generate pharmacological actions such as blocking the vasoconstriction and mediate vasodilatation. Endothelin-1 is a peptide which is comprised of 21 amino acids and formed by vascular endothelium.
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The biological molecule is a potent vasoconstrictor that binds to endothelin receptors A and B. This further leads to the activation of IP3 DA pathway that causes…
Epidermal Growth Factor Receptor (EGFR) Antagonists Therapeutics - Pipeline Anal …
Epidermal growth factor receptors (EGFR) are a group of receptor tyrosine kinase (RTK) that plays a major role in cell proliferation, survival and differentiation. In most of the cancer, EGFR are amplified and overexpressed, due to dysregulation, resulting in cancer development.
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EGFR inhibitors therapies have shown improvement by inhibiting receptor signalling and enhancing the effects of radiation therapy and conventional chemotherapy with their anti-tumor activity. Cetuximab,…
Wnt Signaling Pathway Inhibitors to Witness Significant Growth due to Positive C …
Wnt signaling pathway plays an important role in embryonic development. The signaling pathway regulates cell-to-cell interaction, accelerates trophoblast development, activates blastocyst, accelerate chorion-allantois fusion and implantation. A wide range of diseases, such as different types of cancer and degenerative diseases can be treated by deregulation of components involved in Wnt/β-catenin signaling pathway. Also, researchers have demonstrated that moderate weakening of Wnt signaling can eliminate its carcinogenic potential. Based on the…
Galectin Inhibitor Therapeutics - Pipeline Analysis 2019
Galectins belong to the family of animal lectins and perform function by interacting with cytoplasmic and nuclear proteins, cell-surface and extracellular matrix glycoproteins and glycolipids to modulate signalling pathways. Studies have shown the crucial roles of galectin in cancer as they contribute to tumour cell survival, tumour metastasis, angiogenesis and neoplastic transformation.
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Many studies have demonstrated role of galectins in the pathogenesis of various diseases including…
Mitochondrial-Based Therapeutics to Witness Significant Growth due to Positive C …
According to a new research report “Mitochondrial-Based Therapeutics - Pipeline Analysis 2018, Clinical Trials & Results, Patents, Designations, Collaborations, and Other Developments” published by Pharma Proff, mitochondrial-based therapeutics currently exhibits a strong pipeline with 16 therapeutic candidates.
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Mitochondria are the organelles found in cytoplasm of most eukaryotic cells. These are also known as power-house of the cell. Although, the gene expression of mitochondria has been poorly…
Akt/Protein Kinase B (PKB) Inhibitors to Witness Significant Growth due to Posit …
According to a new research report “Akt/Protein Kinase B (PKB) Inhibitors - Pipeline Analysis 2018, Clinical Trials & Results, Patents, Designations, Collaborations, and Other Developments” published by Pharma Proff Akt/PKB inhibitors therapeutics currently exhibits a proliferating pipeline with 23 therapeutic candidates.
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Akt plays a critical role in the regulation of cell’s apoptotic pathway and it is being studied extensively for targeting cancerous cells. Akt inhibitors are…
Achondroplasia Therapeutics Pipeline is Witnessing Significant Growth due to Pos …
Achondroplasia therapeutics currently exhibits a considerably strong pipeline with seven active drug candidates.
Achondroplasia is a common disorder of dwarfism with disproportionate stature. It is an autosomal dominant disorder that occurs due to mutation in fibroblast growth factor receptor 3 (FGFR3) gene, which is located on short arm of chromosome 4. The disorder is characterized by macrocephaly, shortened-limbs (rhizomelic dwarfism), midface retrusion, and frontal bossing. The achondroplasia therapeutics pipeline study covers…
Immunoglobulin A (IgA) Nephropathy to Witness an Exponential Growth due to Posit …
According to a new research report “Immunoglobulin A (IgA) Nephropathy-Pipeline Analysis, Clinical Trials & Results, Patents, Designations, Collaborations, Patient Size, and Epidemiology Forecast to 2028” published by Pharma Proff, Immunoglobulin A (IgA) Nephropathy therapeutics currently exhibits a proliferating pipeline with 24 therapeutic candidates.
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IgA Nephropathy is referred to being as the utmost causing agent of Glomerulonephritis, which is the inflammation of the glomeruli (part of the…
Rhinovirus Infection Therapeutics to Witness Significant Growth due to Positive …
According to a new research report “Rhinovirus Infection Therapeutics - Pipeline Analysis 2018, Clinical Trials & Results, Patents, Designations, Collaborations, and Other Developments” published by Pharma Proff, rhinovirus infection therapeutics currently exhibits a proliferating pipeline with 10 therapeutic candidates.
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Rhinovirus infections, caused by rhinoviruses, occurs in the upper or lower respiratory tracts. The occurrence frequency of the infection is a year-around, but most often in spring…
Epidermal Growth Factor Receptor (EGFR) Antagonists Therapeutics - Pipeline Anal …
Epidermal growth factor receptors (EGFR) are a group of receptor tyrosine kinase (RTK) that plays a major role in cell proliferation, survival and differentiation. In most of the cancer, EGFR are amplified and overexpressed, due to dysregulation, resulting in cancer development.
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EGFR inhibitors therapies have shown improvement by inhibiting receptor signalling and enhancing the effects of radiation therapy and conventional chemotherapy with their anti-tumor activity. Cetuximab,…
Galectin Inhibitor Therapeutics - Pipeline Analysis 2019
Galectins belong to the family of animal lectins and perform function by interacting with cytoplasmic and nuclear proteins, cell-surface and extracellular matrix glycoproteins and glycolipids to modulate signalling pathways. Studies have shown the crucial roles of galectin in cancer as they contribute to tumour cell survival, tumour metastasis, angiogenesis and neoplastic transformation.
Download the sample Report @ https://www.pharmaproff.com/request-sample/1209
Many studies have demonstrated role of galectins in the pathogenesis of various diseases including…
Wnt Signaling Pathway Inhibitors to Witness Significant Growth due to Positive C …
Wnt signaling pathway plays an important role in embryonic development. The signaling pathway regulates cell-to-cell interaction, accelerates trophoblast development, activates blastocyst, accelerate chorion-allantois fusion and implantation. A wide range of diseases, such as different types of cancer and degenerative diseases can be treated by deregulation of components involved in Wnt/β-catenin signaling pathway. Also, researchers have demonstrated that moderate weakening of Wnt signaling can eliminate its carcinogenic potential. Based on the…
Mitochondrial-Based Therapeutics to Witness Significant Growth due to Positive C …
According to a new research report “Mitochondrial-Based Therapeutics - Pipeline Analysis 2018, Clinical Trials & Results, Patents, Designations, Collaborations, and Other Developments” published by Pharma Proff, mitochondrial-based therapeutics currently exhibits a strong pipeline with 16 therapeutic candidates.
Download the Sample Report @ https://www.pharmaproff.com/request-customization/1212
Mitochondria are the organelles found in cytoplasm of most eukaryotic cells. These are also known as power-house of the cell. Although, the gene expression of mitochondria has been poorly…
