Mitochondrial Myopathies Market 2018 – Major Competitors: are Reata Pharmaceuticals, Inc., Stealth BioTherapeutics etc.

Mitochondrial myopathy is an umbrella term for rare genetic diseases due to defective mitochondria in cells which results in inability of the mitochondria to consume normal levels of oxygen and produce energy. The disease manifests itself from infancy to adulthood.
Although there is no cure for the disease, there have been some research initiatives from pharmaceutical companies. For example, the drug Bendavia of Stealth BioTherapeutics Inc. is undergoing Phase 2 clinical trials and aims to reduce oxidative stress in cells. The drug targets lipids known as cardiolipin, found in the mitochondria to increase energy production.

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Reata Pharmaceuticals has taken the approach of selectively activating cell signalling so as to increase mitochondrial biogenesis, and increase mitochondrial efficiency of energy production. Cysteamine from Raptor Pharmaceuticals is undergoing advanced Phase 3 clinical trials and is targeted to alter glutathione synthesis. The drug intends to increase the conversion of cystine into cysteine which is the critical step for glutathione synthesis. Thus by increasing the conversion of cystine into cysteine and by reducing the level of oxidative damage it will bring long tern cure for Leigh syndrome. Other research initiatives are stem cell therapies and mitochondrial DNA transfers. However these research is still in its infant developmental stage.
Current research aims to increase energy production in the form of adenosine triphosphate (ATP) or to reduce production of free radical. Another strategy is to increase critical enzymatic reactions and scavenge toxic coenzymes, which accumulate during mitochondrial disease. Research is also aiming to find alternative biological energy fuels.

Global Mitochondrial myopathies treatment Market Players:
Key players profiled in the report are Reata Pharmaceuticals, Inc., Stealth BioTherapeutics, Raptor Pharmaceutical Corp., GeneDx, NeuroVive Pharmaceutical AB and others.
Test the market data and market information presented through more than 50 market data tables and figures spread over 80 pages of the project report. Avail the in-depth table of content (TOC) & market synopsis on “Global Mitochondrial myopathies treatment Market” Research Report – Forecast to 2023.

Segmentation:
The global mitochondrial myopathies market is segmented on the basis of type and therapies. Based on type, the market has been segmented as Kearns-Sayre syndrome (KSS), Leigh syndrome, Mitochondrial DNA depletion syndrome (MDS), mitochondrial encephalomyopathy, mitochondrial neuro-gastrointestinal encephalomyopathy (MNGIE), Myoclonus epilepsy with ragged red fibers (MERRF), Neuropathy, ataxia and retinitis pigmentosa (NARP), Pearson syndrome, Progressive external ophthalmoplegia (PEO). Based on the therapies, the market has been segmented as dietary, supportive, vitamins, coenzymes and antioxidants and other.

Regional analysis
US accounts for the maximum market share due to favorable reimbursement scenario and greater expenditure on healthcare. Europe is the second largest market due to large disposable income and rising awareness. Asia Pacific region is the fastest region because of large unmet needs which is led by China and India. The Middle East and Africa market is led by the gulf nations particularly Saudi Arabia and UAE. The poor regions of Africa are expected to be a laggard due to poor economic and political conditions.

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