openPR Logo
Press release

New Study on Renal Diseases - High Degree of Innovation and Diversity with Products Targeting Immune and Hormone Signaling Dominating the Pipeline for Chronic Kidney Disease | Researchmoz

11-20-2017 03:01 PM CET | Business, Economy, Finances, Banking & Insurance

Press release from: Researchmoz.us

Renal Diseases

Renal Diseases

Researchmoz added Most up-to-date research on "Frontier Pharma: Renal Diseases - High Degree of Innovation and Diversity with Products Targeting Immune and Hormone Signaling Dominating the Pipeline for Chronic Kidney Disease" to its huge collection of research reports.

The renal diseases therapy area encompasses a range of diseases of the kidney, such as chronic kidney disease (CKD), acute kidney injury, diabetic nephropathy and focal segmental glomerulosclerosis. Renal diseases are becoming increasingly common due to the increased prevalence of hypertension and diabetes, two major causes of CKD. For most forms of renal diseases, early detection and management may slow down or prevent progression to renal failure and associated complications. However, many renal diseases are typically asymptomatic until they have progressed to end-stage renal disease (ESRD), which requires renal replacement therapies such as hemodialysis and renal transplantation, and is associated with substantial morbidity and mortality.

To Get Sample Copy of Report visit @ https://www.researchmoz.us/enquiry.php?type=S&repid=1370888

The marketed treatments of renal diseases typically focus on controlling the risk factors and complications of renal failure. Treatments include anti-hypertensive agents, hormones, antibiotics, and immunosuppressants. However, these treatments are often not wholly effective, as patients are still at risk of dying prematurely from cardiovascular disease or progressing to ESRD. Few new renal disease therapies have reached the market in the past decade, and with the rising prevalence, there is a high need for innovation and investment in the renal diseases therapy area.

The report assesses first-in-class innovation in the renal diseases pipeline, highlighting key trends and emerging treatment classes. There are 100 first-in-class products in development in this therapy area, which account for 39% of products in the overall pipeline for which there is a disclosed molecular target, and act upon 77 unique individual molecular targets. First-in-class innovation is concentrated heavily at the early drug development stages.

The first-in-class programs identified show considerable diversity, and the relatively high degree of innovation in the renal diseases therapy area makes for a promising development pipeline. It is clear that recent activity in this area has increased, partly owing to the growing recognition of the unmet medical need. Further investment in innovation would benefit the therapy area greatly, and likely prove a worthwhile investment, particularly for highly prevalent diseases such as CKD and diabetic nephropathy, for which there are a lack of effective pharmacotherapeutic options.

Scope

- With 365 products in active development, the pipeline is modestly sized. Does current pipeline innovation hold the potential to affect the future renal diseases market?
- There are 100 first-in-class products in the renal diseases pipeline. Which of these hold the greatest potential to improve future disease treatment with regard to their molecular target?
- The majority of first-in-class products were in development for indications involving inflammation. Which first-in-class targets are most promising, and how does the ratio of first-in-class targets to first-in-class products differ by stage of development and molecular target class?
- A significant number of first-in-class products have been identified with no prior involvement in deals. How do deal frequency and value compare between target families and molecule types, and which first-in-class programs have not yet been involved in a licensing or co-development deal?

Get Complete TOC With Tables and Figures @ https://www.researchmoz.us/frontier-pharma-renal-diseases-high-degree-of-innovation-and-diversity-with-products-targeting-immune-and-hormone-signaling-dominating-the-pipeline-for-chronic-kidney-disease-report.html/toc

Reasons to buy

- Understand the current clinical and commercial landscape. It includes a comprehensive study of disease pathogenesis, diagnosis, prognosis and the treatment options available.
- Visualize the composition of the renal diseases market in terms of dominant molecule types and targets, highlighting what the current unmet needs are and how they can be addressed. This knowledge allows a competitive understanding of gaps in the current market.
- Analyze the renal diseases pipeline and stratify by stage of development, molecule type and molecular target. There are strong signs in the pipeline that the industry is seeking novel approaches to treating renal diseases to overcome the level of unmet need.
- Assess the therapeutic potential of first-in-class targets. Using proprietary matrices, first-in-class products have been assessed and ranked according to clinical potential. The matrices have been split into three categories: renal failure, glomerulonephritides, and renal scarring. Promising targets have been reviewed in greater detail.
- Identify commercial opportunities in the renal diseases deals landscape by analyzing trends in licensing and co-development deals, and producing a list of first-in-class therapies with no prior involvement in licensing or co-development deals

Table of Contents

1 Table of Contents 21.1 List of Tables 3
1.2 List of Figures 3

2 Executive Summary 5
2.1 Unmet Need and Limited Treatment Options Despite Rising Prevalence 5
2.2 Increasing Number of Pipeline Biologics 5
2.3 Significant Degree of First-in-Class Innovation 5
2.4 Low Deal Volume but Large Proportion of High-Value Deals 6

3 The Case for Innovation 7
3.1 Growing Opportunities for Biologic Products 8
3.2 Diversification of Molecular Targets 8
3.3 Innovative First-in-Class Product Developments Remain Attractive 8
3.4 Regulatory and Reimbursement Policy Shifts Favor First-in-Class Product Innovation 9
3.5 Sustained Innovation 9
3.6 GBI Research Report Guidance 10

4 Clinical and Commercial Landscape 11
4.1 Disease Overview 11
4.2 Symptoms 12
4.2.1 Acute Kidney Injury 12
4.2.2 Chronic Kidney Disease 12
4.3 Diagnosis 12
4.3.1 Acute Kidney Injury 12
4.3.2 Chronic Kidney Disease 13
4.4 Etiology and Pathophysiology 13
4.4.1 Renal Anatomy and Physiology 14
4.4.2 Pathophysiological Processes of Renal Diseases 14
4.4.3 Renal Diseases 16
4.5 Epidemiology 18
4.6 Co-morbidities and Complications 19
4.6.1 Anemia 19
4.6.2 Diabetes 19
4.6.3 Cardiovascular Disease 19
4.6.4 Mineral and Bone Disorders 20
4.7 Treatment Options 20
4.7.1 Angiotensin Converting Enzyme Inhibitors 20
4.7.2 Angiotensin II Receptor Blockers 21
4.7.3 Erythropoietin-Stimulating Agents 21
4.7.4 Systemic Immunosuppressants 21
4.7.5 Dialysis 21
4.8 Overview of Marketed Products 22
4.9 Current Unmet Needs 23

5 Assessment of Pipeline Product Innovation 25
5.1 Pipeline by Stage of Development, Molecule Type and Molecular Target 25
5.2 First-in-Class Programs Targeting Novel Molecular Targets 29

6 Renal Diseases Signaling Network, Disease Causation and Innovation Alignment 36
6.1 Complexity of Signaling Networks 36
6.2 Signaling Pathways and First-in-Class Molecular Target Integration 36
6.3 First-in-Class Matrix Assessment 36

Continue...

Make an Enquiry of this report @ https://www.researchmoz.us/enquiry.php?type=E&repid=1370888

About ResearchMoz

ResearchMoz is the one stop online destination to find and buy market research reports & Industry Analysis. We fulfill all your research needs spanning across industry verticals with our huge collection of market research reports. We provide our services to all sizes of organizations and across all industry verticals and markets. Our Research Coordinators have in-depth knowledge of reports as well as publishers and will assist you in making an informed decision by giving you unbiased and deep insights on which reports will satisfy your needs at the best price.

ResearchMoz
State Tower,
90 State Street,
Suite 700,
Albany NY - 12207
United States
Email: sales@researchmoz.us
Website @ https://www.researchmoz.us/
Tel: 866-997-4948 (Us-Canada Toll Free)
Tel: +1-518-621-2074
Follow us on LinkedIn @ http://bit.ly/1TBmnVG

This release was published on openPR.

Permanent link to this press release:

Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.

You can edit or delete your press release New Study on Renal Diseases - High Degree of Innovation and Diversity with Products Targeting Immune and Hormone Signaling Dominating the Pipeline for Chronic Kidney Disease | Researchmoz here

News-ID: 824728 • Views:

More Releases from Researchmoz.us

Bicycle Tires Market - Substantial Rise in Industrial Sectors to Offer Growth Prospects by 2020-2030
Bicycle Tires Market - Substantial Rise in Industrial Sectors to Offer Growth Pr …
A recent market study published by ResearchMoz on the Global Bicycle Tires market includes industry analysis for 2015-2019 & opportunity assessment for 2020-2030, and delivers a comprehensive assessment of the most important market dynamics. After conducting thorough research on the historical and current growth parameters of the Global Bicycle Tires market, the growth prospects of the market are obtained with maximum precision. Request Sample Copy of Research Report @ https://www.researchmoz.us/enquiry.php?type=S&repid=3074346 Chapter 01
Sports And Athletic Insole Market Overview, Cost Structure Analysis, Growth Opportunities and Forecast to 2020-2030
05-19-2021 | Sports
researchmoz.us
Sports And Athletic Insole Market Overview, Cost Structure Analysis, Growth Oppo …
A recent market study published by ResearchMoz on the sports and athletic insole market offers global industry analysis for 2015-2019 & opportunity assessment for 2020-2030. The study offers a comprehensive assessment of the most important market dynamics. After conducting a thorough research on the historical, as well as current growth parameters, the growth prospects of the market are obtained with maximum precision. Request Sample Copy of Research Report @ https://www.researchmoz.us/enquiry.php?type=S&repid=3074345 Chapter 01
Clean Label Pectin Market Development Status, Size, Share, Growth and Forecast Report To 2026
Clean Label Pectin Market Development Status, Size, Share, Growth and Forecast R …
A recent market study published by ResearchMoz on the Clean Label Pectin Market offers global industry analysis for 2014-2019 & opportunity assessment for 2020–2028. The study offers a comprehensive assessment of the most important market dynamics. After conducting a thorough research on the historical, as well as current growth parameters, the growth prospects of the market are obtained with maximum precision. Request Sample Copy of Research Report @ https://www.researchmoz.us/enquiry.php?type=S&repid=3069625 Market Segmentation The global
Citrus Yogurt Market Growth, Demand, And Value Is Increasing In The Upcoming Years 2020-2030
Citrus Yogurt Market Growth, Demand, And Value Is Increasing In The Upcoming Yea …
A recent market study published by ResearchMoz on Citrus Yogurt market offers global industry analysis for 2014-2019 & opportunity assessment for 2020–2028. The study offers a comprehensive assessment of most important market dynamics. After conducting a thorough research on historical, as well as current growth parameters, the growth prospects of market are obtained with maximum precision. Request Sample Copy of Research Report @ https://www.researchmoz.us/enquiry.php?type=S&repid=3067560 Chapter 01 - Executive Summary The executive summary of

All 5 Releases


More Releases for Disease

Biopharmaceutical Fermentation Market 2022 | Growing Morbidity of Genetic Diseas …
According to Precision Business Insights (PBI), the latest report, the biopharmaceutical fermentation market is expected to be valued at USD 10,302.1 million in 2022, growing at a 4.7% CAGR from 2022 to 2028. The growing prevalence of chronic illness, cancer, cardiac diseases, infectious diseases, antibiotic resistance, autoimmune diseases, etc., globally causes the leaning toward biopharmaceutical products, which show promising results in the research studies. Moreover, new findings by the
Global Inflammatory Bowel Disease (IBD) Market Key Players Analysis, Disease Ind …
Global Inflammatory Bowel Disease (IBD) Market, valued at USD 210.5 Billion in the year 2020 has been driven by factors such as the increasing prevalence of Ulcerative Colitis and Crohn’s Disease, advances in medical technology, government support for inflammatory bowel disease treatment research, and the ubiquity of anxiety and depression. Moreover, factors such as the irregular food habits, unhealthy lifestyle of people, increased level of pollution and increase in alcohol
Refsum Disease Industry An Overview of A New Disease - 2018
"Refsum Disease" is a genetic disorder which is inherited as an autosomal recessive trait. The condition is characterized by progressive loss of vision (retinitis pigmentosa), failure of muscle coordination (ataxia), degenerative nerve disease (peripheral neuropathy), and dry, rough, scaly skin (ichthyosis). The accumulation of fatty acid (phytanic acid) in blood plasma and tissues is the main cause of refsum disease. This occurs due to malfunction of the enzyme producing gene
Gaucher Disease Treatment Market, by Disease Type, Therapy Type
Gaucher disease is an autosomal recessive inherited metabolism disorder where a type of fat (lipid) called glucocerebroside is unable to degrade. Body synthesis enzyme called glucocerebrosidase, which breakdowns and reprocesses glucocerebroside. Gaucher disease is caused by mutations of a single gene called GBA, which leads to very low levels of glucocerebrosidase enzyme leading to low degradation of glucocerebroside. There are three types of Gaucher disease namely: type 1, type 2,
Autoimmune Disease Diagnostic Market By Disease, Tests Type, Regions, Companies
"The Latest Research Report Autoimmune Disease Diagnostic Market, Global Forecast, By Disease, Tests Type, Regions, Companies provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz" Autoimmune Disease Diagnostic Market is anticipated to exceed US$ 18 Billion, experiencing a significant growth over the forecast period. Autoimmune diseases take place when there is disruption of the usual control process (immune system of the body becomes
Chagas Disease (Infectious Disease) Pipeline Forecast Report, H1, 2017 [MRH]
Market Research Hub's Pharmaceutical and Healthcare latest pipeline guide Chagas Disease - Pipeline Review, H1 2017, provides comprehensive information on the therapeutics under development for Chagas Disease Market (Infectious Disease), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and