Global Immune Checkpoint Inhibitors Market Analysis, Trends and Forecast 2016 – 2024 | Bristol-Myers Squibb Company, Astra Zeneca plc, Merck & Co., Pfizer, Inc.

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Immune Checkpoint Inhibitors Market: Overview
The immune system of human body depends on multiple checkpoints or immunological breaks, which avoid over-activation of the healthy cells or immune system. Tumor or cancerous cells often take advantage of these checkpoints to escape detection and fight against immune system. To struggle against such cancer cells, the focus of the scientists and drug developers is gradually diverting towards immunotherapeutics, which makes use of the body’s own immune system or its components to fight cancer. The developers have attained successful results with targeted based therapeutics including conjugated and monoclonal antibodies, but there has been a surge of interest in other classes of immunotherapeutics to treat and manage cancer, including immune checkpoint inhibitors, whole cell based therapies and therapeutic cancer vaccines.

On the basis of immune checkpoint inhibitors currently used for treating and management of cancer, the market can be differentiated in two segments which are as follows:

- CLTA-4 Inhibitors
- PD-1 and PD-L1 Inhibitors

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CLTA-4 is aberrantly up-regulated and is present of the surface of T cells in certain cancer, dampening T-cell activation in response to the tumor cells while PD-1 inhibits T-cell function assisting tumor’s ability to invade the immune system. Inhibiting a checkpoint enhance the anti-tumor T-cell response, which results in destruction of cancerous cells. Many giant players worldwide are performing clinical trials with the help of these two immune checkpoint inhibitors and are expected to show positive results during the forecast period. For instance, Pfizer, Inc. in collaboration with the University of Pittsburgh is performing phase 2 clinical trials with Anti-CTLA4 monoclonal antibody to cure recurrent inoperable stage III or stage IV melanoma. Likewise, many other market players are performing clinical trials with CLTA-4 and PD-1 inhibitors and on the basis of previous results, is has been estimated that the molecules are expected to generate few efficient drugs for cancer treatment. In addition to these, many market players have developed some novel immune checkpoint inhibitors which include Elotuzumab, INCB024360, Indoximod, and Lirilumab.

Immune Checkpoint Inhibitors Market: Drivers and Trends

Rising prevalence of the cancer worldwide is the major factor which will boost the immune checkpoint inhibitors market during the forecast period. According to World Health Organization (WHO), cancer was the leading cause of morbidity and mortality in 2012. There were approximately 14 million new cases with 8.2 million cancer related deaths in 2012 worldwide. It has also been reported that the number of new cases will increase by about 70% in the next two decades. Increasing prevalence of the cancer and high rate of associated mortality is demanding for new and effective treatment methods, which will boost the demand for immune checkpoint inhibitors in future.

Moreover, the rising government support and funding towards development of new drugs for cancer treatment also encourages researchers in developing new and novel drugs. For instance, National Cancer Institute, U.S. Department of Human Health and Services, funded approximately USD 5.1 billion for development of cancer treatment drugs and research. The funding from government boosts the research activities and development of new and effective drugs, hence propelling the growth of the market. However, the high cost associated with research activities and sunk costs involved in R&D activities are restraining the immune checkpoint inhibitors market.

The major players which are involved in research and development activities of immune checkpoint inhibitors include Bristol-Myers Squibb Company, Astra Zeneca plc, Merck & Co., Pfizer, Inc., F. Hoffmann-La Roche AG, Incyte Corporation, NewLink Genetics Corporation, Seattle Genetics, Inc., Celldex Therapeutics, GlaxoSmithKline plc, and Innate Pharma S.A.

The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

The study is a source of reliable data on:

- Market segments and sub-segments
- Market trends and dynamics
- Supply and demand
- Market size
- Current trends/opportunities/challenges
- Competitive landscape
- Technological breakthroughs
- Value chain and stakeholder analysis

The regional analysis covers:

- North America (U.S. and Canada)
- Latin America (Mexico, Brazil, Peru, Chile, and others)
- Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, Luxembourg)
- Eastern Europe (Poland, Russia)
- Asia Pacific (China, India, Japan, ASEAN, Australia and New Zealand)
- Middle East and Africa (GCC, Southern Africa, North Africa)

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain.

A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period.

Highlights of the report:

- A complete backdrop analysis, which includes an assessment of the parent market
- Important changes in market dynamics
- Market segmentation up to the second or third level
- Historical, current, and projected size of the market from the standpoint of both value and volume
- Reporting and evaluation of recent industry developments
- Market shares and strategies of key players
- Emerging niche segments and regional markets
- An objective assessment of the trajectory of the market
- Recommendations to companies for strengthening their foothold in the market

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