Global PCR Technologies Market Share, Size, Growth Opportunities, Key Driven Factors, Market Scenario Forecast to 2022

Polymerase Chain Reaction (PCR) is a novel technique which doubles the amount of target DNA in every cycle. The PCR has three steps such as denaturation, annealing and extension, which are repeated in every cycle to achieve the product. PCR market has been divided as products, applications, techniques, end users and geography. PCR products market is further segmented into Instruments, reagents and consumables, software and services. In instruments there are traditional PCR’s and Real time PCR’s. Reagents and consumables are sub segmented into enzymes, dNTP’s, template DNA, primers and probes, buffers, master mixes, nuclease free water, consumable and others (tracking dye and wax beads). Software’s in the PCR market include Primer designers and sequence software’s, PCR data analysis software and others.

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By application, the market is segmented into clinical diagnostics, industrial application, and others (Pathogen detection and dentistry). Clinical diagnostics are further divided into infectious and non infectious diseases. Infectious disease includes hepatitis B & C, tuberculosis, HIV and others. Non infectious diseases include prenatal diagnosis, tissue typing, cancer therapy, genetic typing for hereditary disease, blood screening and others. Industrial applications are divided into Agricultural, Environment, Applied testing, Animal husbandry, Biomedical research and other PCR industry applications. Applied testing includes forensic and food safety testing. Biomedical research includes DNA sequencing, genotyping, biomarker discovery, gene expression and genetic mapping, DNA cloning and others.

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By Technique, the PCR market is segmented into standard PCR, real time PCR, reverse transcriptase PCR, digital PCR, assembly PCR, multiplex PCR, Hot start PCR and others. Others include nested PCR, Inverse PCR, Immune PCR, anchored PCR, RACE PCR, asymmetric PCR, universal PCR, ISSR PCR, allele specific PCR, ligation mediated PCR, touchdown PCR, solid phase PCR, methylation PCR, miniprimer PCR, nanoparticle assisted PCR, overlap extension PCR and In-situ PCR and long PCR. Based on the end- users PCR market is segmented into hospitals and laboratories, pharmaceuticals, CRO’s and biotech companies, academics and others (Blood banks).

Among the PCR technology products, Reagents & Consumables dominated the products market by occupying a largest share of XX%. At the same time, Reagents & Consumables market is the fastest growing segment from 2015 to 2022 with a CAGR of X% and is followed by services with a CAGR of XX%. In applications, the industry applications are the largest segment with XX% share and clinical diagnostics is expected to be the fastest growing segment from 2015 to 2022 with a CAGR of XX%. By end- users, Pharmaceuticals, CRO’s and Biotech companies is the largest segment with a share of XX% and also, the fastest segment with a CAGR of XX% from 2015 to 2022. Geographical wise, North America is the largest market, with a share of XX% followed by Europe and Asia. The APAC region is the fastest growing region with a CAGR of XX% from 2015-2022 to reach $XX million.

The PCR technology market is expected to grow steadily at a CAGR of X% from 2015 to 2022. The factors driving the growth of this market are increasing demand for innovative technology supporting early and accurate diagnosis of life threatening disease, rising demand for PCR in genetic and molecular testing, expiry of key players PCR patents, rising investments in the field of companion diagnostics, advent of digital PCR, increasing RT PCR based food safety testing, increasing affinity for automated high throughput and robotic systems and multiplexed analytical strategies for improving sensitivity and speed of PCR technology. However, high cost of commercial PCR assays in the clinical diagnostics, lack of awareness and requirement of skilled labour and development of alternative technologies are some of the factors restraining PCR Technologies market.

The PCR technologies global market is a highly competitive and all the existing players in this market are involved in developing new and advanced products to maintain their market shares. Some of the Major players in the market are Abbott Laboratories, Inc., Inc. (U.S.), Agilent Technologies (U.S.), Becton, Dickinson and Company (U.S.), BioMerieux SA (France), Bio-Rad Laboratories, Inc. (U.S.), GE Healthcare (U.K.) ), Hoffmann la Roche (Switzerland), Merck KGaA (Germany), Promega Corporation (U.S.), Qiagen N.V. (Netherlands), Takara Bio, Inc.(Japan) and ThermoFisher Scientific, Inc. (U.S.).

The report provides an in depth market analysis of the above mentioned segments across the following regions:

• North America

• Europe

• Asia-Pacific

• Rest of the World (RoW)

Table Of Content

1 EXECUTIVE SUMMARY 29

2 INTRODUCTIONS 38

2.1 KEY TAKE AWAYS 38

2.2 REPORT DESCRIPTION 38

2.3 MARKETS COVERED 40

2.4 STAKEHOLDERS 44

2.5 RESEARCH METHODOLOGY 44

2.5.1 MARKET SIZE ESTIMATION 46

2.5.2 MARKET CRACKDOWN AND DATA TRIANGULATION 48

2.5.3 SECONDARY SOURCES 49

2.5.4 PRIMARY SOURCES 50

2.5.5 KEY DATA POINTS FROM SECONDARY SOURCES 50

2.5.6 KEY DATA POINTS FROM PRIMARY SOURCES 51

2.5.7 ASSUMPTIONS 51

3 MARKET ANALYSIS 53

3.1 INTRODUCTION 53

3.2 MARKET SEGMENTATION 54

3.3 FACTORS INFLUENCING MARKET 56

3.3.1 DRIVERS AND OPPORTUNITIES 56

3.3.1.1 Requirement of early detection of disease 56

3.3.1.2 Rising demand for PCR in genetic and molecular testing 57

3.3.1.3 Expiry of key players PCR patents 58

3.3.1.4 Rising investments in the field of companion diagnostics using pcr 58

3.3.1.5 Advent of digital PCR 59

3.3.1.6 Increasing RT-PCR based food safety testing 59

3.3.1.7 Increasing affinity for automated high throughput and robotic

systems in PCR 60

3.3.1.8 Multiplexed analytical strategies for improving sensitivity

and speed of PCR technology 61

3.3.1.9 Integration of technologies to be expected to accelerate the

speed of DNA analysis processes using PCR 61

3.3.2 RESTRAINTS AND THREATS 62

3.3.2.1 High cost of commercial PCR assays in clinical diagnostics 62

3.3.2.2 Lack of awareness and requirement of skilled labor 62

3.3.2.3 Development of alternate technologies 63

3.3.2.4 Stringent regulatory framework 63

3.3.3 PROBLEM AREAS 64

3.3.3.1 PCR Patent analysis 64

3.3.4 WINNING IMPERATIVE 65

3.3.4.1 PCR Portability 65

3.4 REGULATORY AFFAIRS 65

3.4.1 U.S. 65

3.4.2 EUROPE 66

3.4.3 CHINA 66

3.4.4 INDIA 66

3.4.5 JAPAN 67

3.5 PORTER’S FIVE FORCE ANALYSIS 68

3.5.1 THREAT OF NEW ENTRANTS 69

3.5.2 THREAT OF SUBSTITUTES 69

3.5.3 RIVALRY AMONG EXISTING COMPETITORS 69

3.5.4 BARGAINING POWER OF SUPPLIERS 70

3.5.5 BARGAINING POWER OF BUYERS 70

3.6 SUPPLY CHAIN ANALYSIS 71

3.7 MARKET SHARE ANALYSIS BY MAJOR PLAYERS 73

3.8 PATENT TRENDS 76

4 GLOBAL PCR TECHNIQUES MARKET 78

4.1 INTRODUCTION 78

4.2 STANDARD PCR 80

4.3 REAL TIME PCR/QPCR 82

4.4 REVERSE TRANSCRIPTASE PCR 86

4.5 DIGITAL PCR 87

4.6 ASSEMBLY PCR 90

4.7 MULTIPLEX PCR 92

4.8 HOT START PCR 93

4.9 OTHERS 95

4.9.1 NESTED PCR 95

4.9.2 INVERSE PCR 96

4.9.3 IMMUNO PCR 96

4.9.4 LONG PCR 96

4.9.5 ANCHORED PCR 97

4.9.6 RAPID AMPLIFICATION OF CDNA ENDS (RACE) PCR 97

4.9.7 ASYMMETRIC PCR 98

4.9.8 UNIVERSAL PCR 98

4.9.9 INTER SEQUENCE-SPECIFIC PCR(ISSR-PCR) 98

4.9.10 ALLELE-SPECIFIC PCR 98

4.9.11 LIGATION MEDIATED PCR 98

4.9.12 TOUCHDOWN PCR 99

4.9.13 SOLID PHASE PCR 99

4.9.14 METHYLATION SPECIFIC PCR 99

4.9.15 MINIPRIMER PCR 100

4.9.16 NANOPARTICLE-ASSISTED PCR 100

4.9.17 OVERLAP EXTENSION PCR 100

4.9.18 IN SITU PCR 100

5 GLOBAL PCR PRODUCTS MARKET 102

5.1 INTRODUCTION 102

5.2 INSTRUMENTS 104

5.2.1 TRADITIONAL THERMOCYCLER 106

5.2.2 REAL TIME THERMOCYCLER 107

5.3 REAGENTS & CONSUMABLES 109

5.3.1 ENZYMES 112

5.3.2 DNTP’S 114

5.3.3 TEMPLATE DNA OR CONTROLS 116

5.3.4 PRIMERS AND PROBES 117

5.3.5 BUFFERS 119

5.3.6 MASTER MIXES 120

5.3.7 NUCLEASE FREE WATER 122

5.3.8 CONSUMABLES 123

5.3.9 OTHERS 125

5.4 SOFTWARE 127

5.4.1 PRIMER DESIGN AND SEQUENCING SOFTWARE 129

5.4.2 PCR DATA ANALYZER SOFTWARE 131

5.4.3 OTHERS 132

5.5 SERVICES 133

6 GLOBAL PCR APPLICATIONS MARKET 135

6.1 INTRODUCTION 135

6.2 CLINICAL DIAGNOSTICS 137

6.2.1 INFECTIOUS DISEASES 140

6.2.1.1 Hepatitis B and C testing 143

6.2.1.2 Tuberculosis diagnosis 145

6.2.1.3 HIV Diagnosis 147

6.2.1.4 Others 148

6.2.2 NON INFECTIOUS DISEASES 149

6.2.2.1 Prenatal diagnosis 152

6.2.2.2 Tissue typing 154

6.2.2.3 Cancer therapy 156

6.2.2.4 Genetic testing for hereditory diseases 158

6.2.2.5 Blood screening 160

6.2.2.6 Others 162

……Continued

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